Abstract
Objective: Preconception or antenatal lifestyle interventions in women with obesity may prevent offspring cardiovascular remodelling and adverse cardiovascular outcomes. In recent years, studies have followed-up children of such trials, but the effect on offspring cardiovascular health is unclear. We aimed to systematically review the existing data to examine the impact of maternal lifestyle interventions on offspring cardiovascular remodelling.
Methods: This review was registered with PROSPERO (CRD42023454762) and written in accordance with PRISMA guidelines. PubMed, Embase, and previous reviews were systematically searched. Follow-up studies from randomised interventions in women with obesity that examined the impact on offspring cardiovascular remodelling were included based on pre-defined inclusion criteria.
Results: Eight studies from five trials were included after screening 3252 articles. Two interventions used antenatal exercise, two used diet and physical activity, and one used preconception diet and physical activity. Two studies included offspring <2-months-old and four included children 3–7-years-old. Sample sizes were typically n=60 but ranged between n=18–404. There was evidence of reduced cardiac remodelling, with reduced interventricular septal wall thickness consistently reported. Some studies identified improved systolic and diastolic function and reductions in heart rate. There were no differences in blood pressure or arterial stiffness measures. The main limitation of each study was the large attrition rates.
Conclusions: There was preliminary evidence that preconception/antenatal lifestyle interventions in women with obesity can limit offspring cardiac remodelling. If confirmed in larger studies of older offspring, then these studies could inform public health strategies to improve cardiovascular health of the next generation.
Methods: This review was registered with PROSPERO (CRD42023454762) and written in accordance with PRISMA guidelines. PubMed, Embase, and previous reviews were systematically searched. Follow-up studies from randomised interventions in women with obesity that examined the impact on offspring cardiovascular remodelling were included based on pre-defined inclusion criteria.
Results: Eight studies from five trials were included after screening 3252 articles. Two interventions used antenatal exercise, two used diet and physical activity, and one used preconception diet and physical activity. Two studies included offspring <2-months-old and four included children 3–7-years-old. Sample sizes were typically n=60 but ranged between n=18–404. There was evidence of reduced cardiac remodelling, with reduced interventricular septal wall thickness consistently reported. Some studies identified improved systolic and diastolic function and reductions in heart rate. There were no differences in blood pressure or arterial stiffness measures. The main limitation of each study was the large attrition rates.
Conclusions: There was preliminary evidence that preconception/antenatal lifestyle interventions in women with obesity can limit offspring cardiac remodelling. If confirmed in larger studies of older offspring, then these studies could inform public health strategies to improve cardiovascular health of the next generation.
| Original language | English |
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| Publication status | Accepted/In press - 2024 |
| Event | The 71st Society of Reproductive Investigation Annual Scientific Meeting - Vancouver, Canada Duration: 12 Mar 2024 → 16 Mar 2024 https://www.sri-online.org/events/2024 |
Conference
| Conference | The 71st Society of Reproductive Investigation Annual Scientific Meeting |
|---|---|
| Country/Territory | Canada |
| City | Vancouver |
| Period | 12/03/2024 → 16/03/2024 |
| Internet address |
