MAVRIC: A Multicenter Randomized Controlled Trial of Transabdominal vs Transvaginal Cervical Cerclage

TY - JOUR

T1 - MAVRIC

T2 - A Multicenter Randomized Controlled Trial of Transabdominal vs Transvaginal Cervical Cerclage

AU - Shennan, Andrew

AU - Chandiramani, Manju

AU - Bennett, Phillip

AU - David, Anna L.

AU - Girling, Joanna

AU - Ridout, Alexandra

AU - Seed, Paul T.

AU - Simpson, Nigel

AU - Thornton, Steven

AU - Tydeman, Graham

AU - Quenby, Siobhan

AU - Carter, Jenny

N1 - Publisher Copyright: © Wolters Kluwer Health, Inc. All rights reserved.

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Womenwho experience multiple late miscarriages or spontaneous pretermbirths may be candidates for vaginal cerclage. In women with a history of pregnancy loss with vaginal cerclage, observational studies have suggested that transabdominal cerclage (TAC) may be beneficial over high vaginal cerclage (HVC) and low vaginal cerclage (LVC). However, TAC has not been evaluated in a randomized clinical trial. The aim of this study was to determine if TAC or HVC would result in lower rates of late miscarriage or preterm births compared with LVC in women with a history of pregnancy loss. The Multicentre Abdominal vs Vaginal Randomized Intervention of Cerclage trial was a multicenter randomized clinical trial involving 9 hospitals across the United Kingdom. Women were recruited between January 2008 and September 2014. Eligibility for the study included a history of spontaneous late miscarriage or preterm birth between 14 and 28 weeks of pregnancy with a previous failed cerclage. Women requiring rescue cerclage procedures were excluded.

AB - Womenwho experience multiple late miscarriages or spontaneous pretermbirths may be candidates for vaginal cerclage. In women with a history of pregnancy loss with vaginal cerclage, observational studies have suggested that transabdominal cerclage (TAC) may be beneficial over high vaginal cerclage (HVC) and low vaginal cerclage (LVC). However, TAC has not been evaluated in a randomized clinical trial. The aim of this study was to determine if TAC or HVC would result in lower rates of late miscarriage or preterm births compared with LVC in women with a history of pregnancy loss. The Multicentre Abdominal vs Vaginal Randomized Intervention of Cerclage trial was a multicenter randomized clinical trial involving 9 hospitals across the United Kingdom. Women were recruited between January 2008 and September 2014. Eligibility for the study included a history of spontaneous late miscarriage or preterm birth between 14 and 28 weeks of pregnancy with a previous failed cerclage. Women requiring rescue cerclage procedures were excluded.

UR - http://www.scopus.com/inward/record.url?scp=85092416032&partnerID=8YFLogxK

U2 - 10.1097/01.ogx.0000688028.31211.10

DO - 10.1097/01.ogx.0000688028.31211.10

M3 - Comment/debate

AN - SCOPUS:85092416032

SN - 0029-7828

VL - 75

SP - 392

EP - 394

JO - Obstetrical and Gynecological Survey

JF - Obstetrical and Gynecological Survey

IS - 7

ER -