Maximising living donation with paediatric blood-group-incompatible renal transplantation

Nizam Mamode, Stephen D. Marks*

*Corresponding author for this work

    Research output: Contribution to journalLiterature reviewpeer-review

    12 Citations (Scopus)

    Abstract

    Long-term outcomes for paediatric renal transplant recipients have improved over the last 20 years, with better patient and renal allograft survival. As paediatric renal transplantation programmes have increased over this timeframe, living donation has become the favoured modality for renal replacement therapy and is advocated pre-emptively in as many cases as possible. However, one of the main barriers historically to living donation has been ABO blood-group incompatibility, with the result that patients were listed to be on call for a deceased donor renal transplant. The clinical scenario has now changed so that donors and recipients for renal transplantation can be worked up and listed for paired exchange and/or living-related ABO blood-group-incompatible renal transplantation (ABOi). There is extensive data in adult practice, and increasing evidence in paediatric practice that the short- and medium-term outcomes for both patient and renal allograft survival for ABOi is equivalent to that of blood-group-compatible renal transplantation.

    Original languageEnglish
    Pages (from-to)1037-1040
    Number of pages4
    JournalPediatric Nephrology
    Volume28
    Issue number7
    DOIs
    Publication statusPublished - Jul 2013

    Keywords

    • Blood group
    • ABO incompatibility
    • Renal transplantation
    • Outcomes
    • Paediatric
    • DONOR KIDNEY-TRANSPLANTATION
    • ABO
    • RITUXIMAB
    • OUTCOMES
    • JAPAN

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