MEAsUREMENT of myocardial blood flow in atrial fibrillation USING high-resolution, free-breathing IN-LINE quantitative cardiovascular magnetic resonance

TY - JOUR

T1 - MEAsUREMENT of myocardial blood flow in atrial fibrillation USING high-resolution, free-breathing IN-LINE quantitative cardiovascular magnetic resonance

AU - Crawley, Richard J

AU - Kunze, Karl-Philipp

AU - Mbbs, Anmol Kaushal

AU - Milidonis, Xenios

AU - Highton, Jack

AU - Domenech-Ximenos, Blanca

AU - Kotadia, Irum D

AU - Karamanli, Çan

AU - Wong, Nathan C K

AU - Mbbs, Robbie Murphy

AU - Alskaf, Ebraham

AU - Neji, Radhouene

AU - O'Neill, Mark

AU - Williams, Steven E

AU - Scannell, Cian M

AU - Plein, Sven

AU - Chiribiri, Amedeo

N1 - Copyright © 2025 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2025/12/1

Y1 - 2025/12/1

N2 - Background: Stress perfusion cardiovascular magnetic resonance (CMR) in the presence of atrial fibrillation (AF) has long been challenging due to electrocardiogram (ECG) mis-triggering. However, non-invasive ischemia imaging is important due to an increased risk of myocardial infarction in patients with AF, which has been attributed to underlying microvascular dysfunction. Myocardial blood flow (MBF) in patients with AF is poorly understood, and few studies have attempted to quantify this through non-invasive imaging. Methods: Patients were recruited for stress perfusion CMR using a research sequence at 3-Tesla. Image acquisition occurred during both vasodilator-induced hyperemia and at rest. Stress and rest MBF maps were automatically generated. Analysis of perfusion maps included assessment of myocardial perfusion reserve (MPR) and endocardial-to-epicardial MBF ratios. Results: Around 442 patients were analyzed; 63 of whom had a history of AF and were in AF during the scan. Both MBF during hyperemia (stress MBF) and MPR were reduced in patients with AF compared to those in sinus rhythm (median stress MBF 1.85 [1.52–2.24] vs. 2.35 [1.98–2.77] mL/min/g, p<0.001; median MPR 1.95 [1.62–2.19] vs. 2.37 [2.05–2.80], p<0.001). No significant difference was seen between the two groups at rest (p=0.451). When considering co-factors affecting MBF, multivariate linear regression analysis identified the presence of AF as a significant independent contributor to stress MBF and MPR values. Both endocardial and epicardial stress MBF and MPR were reduced in AF compared with sinus rhythm (both p<0.001) and endocardial/epicardial ratios were similar between the groups. Conclusion: Automated quantitative MBF assessment can be performed in patients with AF. At hyperemia, MBF is reduced in AF compared to sinus rhythm.

AB - Background: Stress perfusion cardiovascular magnetic resonance (CMR) in the presence of atrial fibrillation (AF) has long been challenging due to electrocardiogram (ECG) mis-triggering. However, non-invasive ischemia imaging is important due to an increased risk of myocardial infarction in patients with AF, which has been attributed to underlying microvascular dysfunction. Myocardial blood flow (MBF) in patients with AF is poorly understood, and few studies have attempted to quantify this through non-invasive imaging. Methods: Patients were recruited for stress perfusion CMR using a research sequence at 3-Tesla. Image acquisition occurred during both vasodilator-induced hyperemia and at rest. Stress and rest MBF maps were automatically generated. Analysis of perfusion maps included assessment of myocardial perfusion reserve (MPR) and endocardial-to-epicardial MBF ratios. Results: Around 442 patients were analyzed; 63 of whom had a history of AF and were in AF during the scan. Both MBF during hyperemia (stress MBF) and MPR were reduced in patients with AF compared to those in sinus rhythm (median stress MBF 1.85 [1.52–2.24] vs. 2.35 [1.98–2.77] mL/min/g, p<0.001; median MPR 1.95 [1.62–2.19] vs. 2.37 [2.05–2.80], p<0.001). No significant difference was seen between the two groups at rest (p=0.451). When considering co-factors affecting MBF, multivariate linear regression analysis identified the presence of AF as a significant independent contributor to stress MBF and MPR values. Both endocardial and epicardial stress MBF and MPR were reduced in AF compared with sinus rhythm (both p<0.001) and endocardial/epicardial ratios were similar between the groups. Conclusion: Automated quantitative MBF assessment can be performed in patients with AF. At hyperemia, MBF is reduced in AF compared to sinus rhythm.

UR - https://www.scopus.com/pages/publications/105010502944

U2 - 10.1016/j.jocmr.2025.101917

DO - 10.1016/j.jocmr.2025.101917

M3 - Article

C2 - 40484175

SN - 1097-6647

VL - 27

SP - 101917

JO - Journal of Cardiovascular Magnetic Resonance

JF - Journal of Cardiovascular Magnetic Resonance

IS - 2

M1 - 101917

ER -