Measuring drug occupancy in the absence of a reference region: the Lassen plot re-visited

Vincent J Cunningham, Eugenii A Rabiner, Mark Slifstein, Marc Laruelle, Roger N Gunn

Research output: Contribution to journalArticlepeer-review

218 Citations (Scopus)


Quantitative estimation of neuroreceptor occupancy by exogenous drugs using positron emission tomography is based on the reduction in the total volume of distribution (V(T)) of site-specific radioligands after drug administration. An estimate of the distribution volume of free and nonspecifically bound radioligand (V(ND)) is also required to distinguish specific from total binding. However, a true reference region, devoid of specific binding, is often not available. We present a transformation of a graphical method, originally introduced by Lassen, using regional estimates of V(T) alone to determine occupancy, together with an extension that does not require baseline data.
Original languageEnglish
Article numberN/A
Pages (from-to)46-50
Number of pages5
JournalJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Issue number1
Early online date9 Sept 2009
Publication statusPublished - Jan 2010


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