@inbook{59e5ca46081f423980d7cdde3ca28b2a,
title = "Mechanically directing the differention and organisation of stem cell to recapitulate key liver function",
abstract = "The nucleus has recently emerged as an important mechano-sensory organelle in the cell. Studies have provided evidence that the nucleus can respond to mechanical stimuli such as constriction, which can modulate the epigenetic landscape and enable expression of genes. Our study aims to develop a simple, reproducible and affordable device which stimulates the nucleus, to improve human iPSCs differentiation to cells with equivalent function to primary hepatocytes. We optimized the microgroove geometry platform to impose nuclear stimulation and preliminary data shows that this stimulation achieved 5-fold significant increase in function of stimulated iPSCs-derived hepatocytes.",
keywords = "Hepatocytes, Liver, Microgrooves, Nuclear constriction, Polydimethylsiloxane PDMS",
author = "Mary Okesola and Rashid, {Tamir S.} and Ciro Chiappini",
year = "2020",
language = "English",
series = "MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "296--297",
booktitle = "MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
note = "24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 ; Conference date: 04-10-2020 Through 09-10-2020",
}