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Mechanically directing the differention and organisation of stem cell to recapitulate key liver function

Research output: Chapter in Book/Report/Conference proceedingConference paperpeer-review

Original languageEnglish
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages296-297
Number of pages2
ISBN (Electronic)9781733419017
Published2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duration: 4 Oct 20209 Oct 2020

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period4/10/20209/10/2020

King's Authors

Abstract

The nucleus has recently emerged as an important mechano-sensory organelle in the cell. Studies have provided evidence that the nucleus can respond to mechanical stimuli such as constriction, which can modulate the epigenetic landscape and enable expression of genes. Our study aims to develop a simple, reproducible and affordable device which stimulates the nucleus, to improve human iPSCs differentiation to cells with equivalent function to primary hepatocytes. We optimized the microgroove geometry platform to impose nuclear stimulation and preliminary data shows that this stimulation achieved 5-fold significant increase in function of stimulated iPSCs-derived hepatocytes.

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