Mechanisms, Hallmarks, and Implications of Stem Cell Quiescence

Inchul J Cho, Prudence PokWai Lui, Jana Obajdin, Federica Riccio, Wladislaw Stroukov, Thea Louise Willis, Francesca Spagnoli, Fiona M Watt

Research output: Contribution to journalReview articlepeer-review

93 Citations (Scopus)

Abstract

Cellular quiescence is a dormant but reversible cellular state in which cell-cycle entry and proliferation are prevented. Recent studies both in vivo and in vitro demonstrate that quiescence is actively maintained through synergistic interactions between intrinsic and extrinsic signals. Subtypes of adult mammalian stem cells can be maintained in this poised, quiescent state, and subsequently reactivated upon tissue injury to restore homeostasis. However, quiescence can become deregulated in pathological settings. In this review, we discuss the recent advances uncovering intracellular signaling pathways, transcriptional changes, and extracellular cues within the stem cell niche that control induction and exit from quiescence in tissue stem cells. We discuss the implications of quiescence as well as the pharmacological and genetic approaches that are being explored to either induce or prevent quiescence as a therapeutic strategy.

Original languageEnglish
Pages (from-to)1190-1200
Number of pages11
JournalStem cell reports
Volume12
Issue number6
DOIs
Publication statusPublished - 11 Jun 2019

Keywords

  • autophagy
  • cancer
  • cell cycle
  • cell therapy
  • niche
  • quiescence
  • stem cells

Fingerprint

Dive into the research topics of 'Mechanisms, Hallmarks, and Implications of Stem Cell Quiescence'. Together they form a unique fingerprint.

Cite this