Mechanisms of acute cough

C Page; S M Reynolds; A J Mackenzie; P Geppetti

Mechanisms of acute cough

C Page
, S M Reynolds
, A J Mackenzie
, P Geppetti

Institute of Pharmaceutical Science

Research output: Contribution to journal › Conference paper

6 Citations (Scopus)

Abstract

The physiology of cough has become one of the primary focuses of recent research into the cough reflex. Peripherally, interest in differentiating subtypes of airway afferent fibres to determine their contributions to the cough reflex has led to the discovery of an RAR-fibre subtype that responds exclusively to tussive stimuli in the anaesthetized guinea pig and has been hypothesized to initiate the normal defensive cough reflex. Further investigations have begun to more fully differentiate these and other afferent fibre types pharmacologically. Centrally, investigations into the involvement of respiratory networks and gating mechanisms in the cough reflex have contributed to our understanding of the control of cough. Pathological changes in the cough reflex resulting from disease are also beginning to be elucidated. Further research in this area should lead to a more complete understanding of cough and a more rational approach to its treatment. (C) 2004 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	389 - 391
Number of pages	3
Journal	PULMONARY PHARMACOLOGY AND THERAPEUTICS
Volume	17
Issue number	6
Publication status	Published - Dec 2004
Event	3rd International Symposium on Cough - London, ENGLAND Duration: 1 Jan 2004 → …

Cite this

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title = "Mechanisms of acute cough",

abstract = "The physiology of cough has become one of the primary focuses of recent research into the cough reflex. Peripherally, interest in differentiating subtypes of airway afferent fibres to determine their contributions to the cough reflex has led to the discovery of an RAR-fibre subtype that responds exclusively to tussive stimuli in the anaesthetized guinea pig and has been hypothesized to initiate the normal defensive cough reflex. Further investigations have begun to more fully differentiate these and other afferent fibre types pharmacologically. Centrally, investigations into the involvement of respiratory networks and gating mechanisms in the cough reflex have contributed to our understanding of the control of cough. Pathological changes in the cough reflex resulting from disease are also beginning to be elucidated. Further research in this area should lead to a more complete understanding of cough and a more rational approach to its treatment. (C) 2004 Elsevier Ltd. All rights reserved.",

author = "C Page and Reynolds, \{S M\} and Mackenzie, \{A J\} and P Geppetti",

year = "2004",

month = dec,

language = "English",

volume = "17",

pages = "389 -- 391",

journal = "PULMONARY PHARMACOLOGY AND THERAPEUTICS",

publisher = "Elsevier",

number = "6",

note = "3rd International Symposium on Cough ; Conference date: 01-01-2004",

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TY - JOUR

T1 - Mechanisms of acute cough

AU - Page, C

AU - Reynolds, S M

AU - Mackenzie, A J

AU - Geppetti, P

PY - 2004/12

Y1 - 2004/12

N2 - The physiology of cough has become one of the primary focuses of recent research into the cough reflex. Peripherally, interest in differentiating subtypes of airway afferent fibres to determine their contributions to the cough reflex has led to the discovery of an RAR-fibre subtype that responds exclusively to tussive stimuli in the anaesthetized guinea pig and has been hypothesized to initiate the normal defensive cough reflex. Further investigations have begun to more fully differentiate these and other afferent fibre types pharmacologically. Centrally, investigations into the involvement of respiratory networks and gating mechanisms in the cough reflex have contributed to our understanding of the control of cough. Pathological changes in the cough reflex resulting from disease are also beginning to be elucidated. Further research in this area should lead to a more complete understanding of cough and a more rational approach to its treatment. (C) 2004 Elsevier Ltd. All rights reserved.

AB - The physiology of cough has become one of the primary focuses of recent research into the cough reflex. Peripherally, interest in differentiating subtypes of airway afferent fibres to determine their contributions to the cough reflex has led to the discovery of an RAR-fibre subtype that responds exclusively to tussive stimuli in the anaesthetized guinea pig and has been hypothesized to initiate the normal defensive cough reflex. Further investigations have begun to more fully differentiate these and other afferent fibre types pharmacologically. Centrally, investigations into the involvement of respiratory networks and gating mechanisms in the cough reflex have contributed to our understanding of the control of cough. Pathological changes in the cough reflex resulting from disease are also beginning to be elucidated. Further research in this area should lead to a more complete understanding of cough and a more rational approach to its treatment. (C) 2004 Elsevier Ltd. All rights reserved.

UR - https://www.scopus.com/pages/publications/9644303366

M3 - Conference paper

VL - 17

SP - 389

EP - 391

JO - PULMONARY PHARMACOLOGY AND THERAPEUTICS

JF - PULMONARY PHARMACOLOGY AND THERAPEUTICS

IS - 6

T2 - 3rd International Symposium on Cough

Y2 - 1 January 2004

ER -

Mechanisms of acute cough

Abstract

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