Mechanistic insight into how gonadotropin hormone receptor complexes direct signaling1

TY - JOUR

T1 - Mechanistic insight into how gonadotropin hormone receptor complexes direct signaling1

AU - Johnson, Gillian P

AU - Jonas, Kim Carol

N1 - © The Author(s) 2019. Published by Oxford University Press on behalf of Society for the Study of Reproduction.

PY - 2019/12/28

Y1 - 2019/12/28

N2 - Gonadotropin hormones and their receptors play a central role in the control of male and female reproduction. In recent years, there has been growing evidence surrounding the complexity of gonadotropin hormone/receptor signalling, with it increasingly apparent that the Gαs/cAMP/PKA pathway is not the sole signalling pathway that confers their biological actions. Here we review recent literature on the different receptor-receptor, receptor-scaffold and receptor-signaling molecule complexes formed and how these modulate and direct gonadotropin hormone-dependent intracellular signal activation. We will touch upon the more controversial issue of extragonadal expression of FSHR and the differential signal pathways activated in these tissues, and lastly, highlight the open questions surrounding the role these gonadotropin hormone receptor complexes, and how this will shape future research directions.

AB - Gonadotropin hormones and their receptors play a central role in the control of male and female reproduction. In recent years, there has been growing evidence surrounding the complexity of gonadotropin hormone/receptor signalling, with it increasingly apparent that the Gαs/cAMP/PKA pathway is not the sole signalling pathway that confers their biological actions. Here we review recent literature on the different receptor-receptor, receptor-scaffold and receptor-signaling molecule complexes formed and how these modulate and direct gonadotropin hormone-dependent intracellular signal activation. We will touch upon the more controversial issue of extragonadal expression of FSHR and the differential signal pathways activated in these tissues, and lastly, highlight the open questions surrounding the role these gonadotropin hormone receptor complexes, and how this will shape future research directions.

U2 - 10.1093/biolre/ioz228

DO - 10.1093/biolre/ioz228

M3 - Article

C2 - 31882999

SN - 0006-3363

JO - Biology of Reproduction

JF - Biology of Reproduction

ER -