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Mechanobiology-chemical origin of membrane mechanical resistance and force-dependent signaling

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)87-93
Number of pages7
JournalCURRENT OPINION IN CHEMICAL BIOLOGY
Volume29
DOIs
Published1 Dec 2015

King's Authors

Abstract

The cell membrane is a highly complex designed material with remarkable physicochemical properties; comprised mainly of lipid moieties, it is capable of self-assembling, changing morphology, housing a range of distinct proteins, and withstanding electrical, chemical and mechanical perturbations. All of these fundamental cellular functions occurring within a 5. nm thick film is an astonishing feat of engineering, made possible due to the interplay of a variety of intermolecular forces. Elucidating how the interactions within the chemically distinct partners influence the nanomechanical properties of the membrane is essential to gain a comprehensive understanding of a wide-variety of both force-triggered and force-sensing mechanisms that dictate essential cellular processes.

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