Medial frontal gyrus alterations in schizophrenia: Relationship with duration of illness and executive dysfunction

Marianna Frascarelli, Stefania Tognin, Alessia Mirigliani*, Fabrizio Parente, Antonino Buzzanca, Maria Chiara Torti, Emanuele Tinelli, Francesca Caramia, Fabio Di Fabio, Massimo Biondi, Paolo Fusar-Poli

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Executive functioning is consistently impaired in schizophrenia, and it has been associated with reduced gray matter volume in prefrontal areas. Abnormalities in prefrontal brain regions have also been related to the illness duration. The aim of the study was to investigate the effect of executive functioning decline and chronicity in prefrontal regions of patients with schizophrenia. Participants comprised 33 schizophrenic patients, 18 with duration of illness (Dol) shorter than 10 years and 15 with duration of illness longer than 10 years. In addition, 24 healthy controls served as a comparison group. Participants performed the Wisconsin Card Sorting Test (WCST) and underwent structural magnetic resonance imaging. Patients with longer Dol showed significant reduction of gray matter volume in the left medial frontal gyms compared with healthy controls. Moreover, there was a trend for greater gray matter volume decrease in patients with a longer illness duration compared with patients with shorter illness duration. There was no interaction between the volume of the left medial frontal gyms performance on the WCST. The present study supports the hypothesis that medial frontal gyrus alterations in schizophrenia are sensitive to duration of illness. These alterations were not associated with executive functioning.

Original languageEnglish
Pages (from-to)103-110
Number of pages8
JournalPsychiatry Research. Neuroimaging
Volume231
Issue number2
Early online date18 Nov 2014
DOIs
Publication statusPublished - 28 Feb 2015

Keywords

  • Voxel-based morphometry
  • Wisconsin Card Sorting Test
  • Schizophrenia
  • Gray matter
  • VOXEL-BASED MORPHOMETRY
  • REGIONAL BRAIN MORPHOLOGY
  • NEGATIVE SYNDROME SCALE
  • CARD SORTING TEST
  • COGNITIVE DEFICITS
  • 1ST-EPISODE SCHIZOPHRENIA
  • ANTIPSYCHOTIC TREATMENT
  • 5-FACTOR MODEL
  • TEMPORAL-LOBE
  • MATTER VOLUME

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