Medial vascular calcification revisited: review and perspectives

Peter Lanzer*, Manfred Boehm, Victor Sorribas, Marc Thiriet, Jan Janzen, Thomas Zeller, Cynthia St Hilaire, Catherine Shanahan

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

546 Citations (Scopus)

Abstract

Vascular calcifications (VCs) are actively regulated biological processes associated with crystallization of hydroxyapatite in the extracellular matrix and in cells of the media (VCm) or intima (VCi) of the arterial wall. Both patterns of VC often coincide and occur in patients with type II diabetes, chronic kidney disease, and other less frequent disorders; VCs are also typical in senile degeneration. In this article, we review the current state of knowledge about the pathology, molecular biology, and nosology of VCm, expand on potential mechanisms responsible for poor prognosis, and expose some of the directions for future research in this area.

Original languageEnglish
Pages (from-to)1515-1525c
Number of pages14
JournalEuropean Heart Journal
Volume35
Issue number23
DOIs
Publication statusPublished - Jun 2014

Keywords

  • Vascular calcifications
  • Monckeberg's media sclerosis
  • Vascular molecular biology and genetics
  • Vascular function
  • SMOOTH-MUSCLE-CELLS
  • CALCIUM-PHOSPHATE DEPOSITION
  • AMERICAN-HEART-ASSOCIATION
  • CHRONIC KIDNEY-DISEASE
  • FETUIN-A LEVELS
  • ARTERIAL CALCIFICATION
  • ATHEROSCLEROTIC LESIONS
  • CARDIOVASCULAR-DISEASE
  • MONCKEBERGS SCLEROSIS
  • CORONARY-ARTERIES

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