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Medium-sized rings: conformational preferences in cyclooctanone driven by transannular repulsive interactions

Research output: Contribution to journalArticle

Original languageEnglish
Article numberC8CP07322H
Pages (from-to)4331-4338
Number of pages8
JournalPhysical Chemistry Chemical Physics
Volume21
Issue number8
Early online date28 Jan 2019
DOIs
Accepted/In press28 Jan 2019
E-pub ahead of print28 Jan 2019
Published28 Feb 2019

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King's Authors

Abstract

The conformational properties of medium-sized rings are of relevance to understand their intramolecular interactions and reactivity. Here we have characterised the conformational landscape of the eight-membered ketone cyclooctanone by broadband rotational spectroscopy in combination with quantum-chemistry calculations. Three conformers, two boat-chair and one twisted boat chair configurations, have been identified and their spectroscopic parameters determined. Cyclooctanone predominantly exists in the global minimum boat-chair conformation, whose bond lengths and angles have been determined for the first time. The relative abundance of the global minimun with respect to the second conformer in the energy ordering, a twisted boat-chair, is 40:1 in all carrier gases used in the supersonic expansion. The conformational preferences of cyclooctanone are driven by minimization of repulsive non-bonded transannular interactions.

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