Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group

André Zugman; Anita Harrewijn; Elise M. Cardinale; Hannah Zwiebel; Gabrielle F. Freitag; Katy E. Werwath; Janna M. Bas-Hoogendam; Nynke A. Groenewold; Moji Aghajani; Kevin Hilbert; Narcis Cardoner; Daniel Porta-Casteràs; Savannah Gosnell; Ramiro Salas; Karina S. Blair; James R. Blair; Mira Z. Hammoud; Mohammed Milad; Katie Burkhouse; K. Luan Phan; Heidi K. Schroeder; Jeffrey R. Strawn; Katja Beesdo-Baum; Sophia I. Thomopoulos; Hans J. Grabe; Sandra Van der Auwera; Katharina Wittfeld; Jared A. Nielsen; Randy Buckner; Jordan W. Smoller; Benson Mwangi; Jair C. Soares; Mon Ju Wu; Giovana B. Zunta-Soares; Andrea P. Jackowski; Pedro M. Pan; Giovanni A. Salum; Michal Assaf; Gretchen J. Diefenbach; Paolo Brambilla; Eleonora Maggioni; David Hofmann; Thomas Straube; Carmen Andreescu; Rachel Berta; Erica Tamburo; Rebecca Price; Gisele G. Manfro; Hugo D. Critchley; Elena Makovac; Matteo Mancini; Frances Meeten; Cristina Ottaviani; Federica Agosta; Elisa Canu; Camilla Cividini; Massimo Filippi; Milutin Kostić; Ana Munjiza; Courtney A. Filippi; Ellen Leibenluft; Bianca A.V. Alberton; Nicholas L. Balderston; Monique Ernst; Christian Grillon; Lilianne R. Mujica-Parodi; Helena van Nieuwenhuizen; Gregory A. Fonzo; Martin P. Paulus; Murray B. Stein; Raquel E. Gur; Ruben C. Gur; Antonia N. Kaczkurkin; Bart Larsen; Theodore D. Satterthwaite; Jennifer Harper; Michael Myers; Michael T. Perino; Qiongru Yu; Chad M. Sylvester; Dick J. Veltman; Ulrike Lueken; Nic J.A. Van der Wee; Dan J. Stein; Neda Jahanshad; Paul M. Thompson; Daniel S. Pine; Anderson M. Winkler

doi:10.1002/hbm.25096

Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group

André Zugman^*, Anita Harrewijn, Elise M. Cardinale, Hannah Zwiebel, Gabrielle F. Freitag, Katy E. Werwath, Janna M. Bas-Hoogendam, Nynke A. Groenewold, Moji Aghajani, Kevin Hilbert, Narcis Cardoner, Daniel Porta-Casteràs, Savannah Gosnell, Ramiro Salas, Karina S. Blair, James R. Blair, Mira Z. Hammoud, Mohammed Milad, Katie Burkhouse, K. Luan PhanHeidi K. Schroeder, Jeffrey R. Strawn, Katja Beesdo-Baum, Sophia I. Thomopoulos, Hans J. Grabe, Sandra Van der Auwera, Katharina Wittfeld, Jared A. Nielsen, Randy Buckner, Jordan W. Smoller, Benson Mwangi, Jair C. Soares, Mon Ju Wu, Giovana B. Zunta-Soares, Andrea P. Jackowski, Pedro M. Pan, Giovanni A. Salum, Michal Assaf, Gretchen J. Diefenbach, Paolo Brambilla, Eleonora Maggioni, David Hofmann, Thomas Straube, Carmen Andreescu, Rachel Berta, Erica Tamburo, Rebecca Price, Gisele G. Manfro, Hugo D. Critchley, Elena Makovac, Matteo Mancini, Frances Meeten, Cristina Ottaviani, Federica Agosta, Elisa Canu, Camilla Cividini, Massimo Filippi, Milutin Kostić, Ana Munjiza, Courtney A. Filippi, Ellen Leibenluft, Bianca A.V. Alberton, Nicholas L. Balderston, Monique Ernst, Christian Grillon, Lilianne R. Mujica-Parodi, Helena van Nieuwenhuizen, Gregory A. Fonzo, Martin P. Paulus, Murray B. Stein, Raquel E. Gur, Ruben C. Gur, Antonia N. Kaczkurkin, Bart Larsen, Theodore D. Satterthwaite, Jennifer Harper, Michael Myers, Michael T. Perino, Qiongru Yu, Chad M. Sylvester, Dick J. Veltman, Ulrike Lueken, Nic J.A. Van der Wee, Dan J. Stein, Neda Jahanshad, Paul M. Thompson, Daniel S. Pine, Anderson M. Winkler

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

45 Citations (Scopus)

Abstract

The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega-analyses.

Original language	English
Pages (from-to)	255-277
Number of pages	23
Journal	Human Brain Mapping
Volume	43
Issue number	1
DOIs	https://doi.org/10.1002/hbm.25096
Publication status	Published - Jan 2022

Keywords

data sharing
generalized anxiety disorder
mega-analyses
meta-analyses
neuroimaging

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10.1002/hbm.25096

Cite this

Zugman, A., Harrewijn, A., Cardinale, E. M., Zwiebel, H., Freitag, G. F., Werwath, K. E., Bas-Hoogendam, J. M., Groenewold, N. A., Aghajani, M., Hilbert, K., Cardoner, N., Porta-Casteràs, D., Gosnell, S., Salas, R., Blair, K. S., Blair, J. R., Hammoud, M. Z., Milad, M., Burkhouse, K., ... Winkler, A. M. (2022). Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group. Human Brain Mapping, 43(1), 255-277. https://doi.org/10.1002/hbm.25096

@article{8cffa9e5111b4850ac32413615c01fdd,

title = "Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group",

abstract = "The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega-analyses.",

keywords = "data sharing, generalized anxiety disorder, mega-analyses, meta-analyses, neuroimaging",

author = "Andr{\'e} Zugman and Anita Harrewijn and Cardinale, {Elise M.} and Hannah Zwiebel and Freitag, {Gabrielle F.} and Werwath, {Katy E.} and Bas-Hoogendam, {Janna M.} and Groenewold, {Nynke A.} and Moji Aghajani and Kevin Hilbert and Narcis Cardoner and Daniel Porta-Caster{\`a}s and Savannah Gosnell and Ramiro Salas and Blair, {Karina S.} and Blair, {James R.} and Hammoud, {Mira Z.} and Mohammed Milad and Katie Burkhouse and Phan, {K. Luan} and Schroeder, {Heidi K.} and Strawn, {Jeffrey R.} and Katja Beesdo-Baum and Thomopoulos, {Sophia I.} and Grabe, {Hans J.} and {Van der Auwera}, Sandra and Katharina Wittfeld and Nielsen, {Jared A.} and Randy Buckner and Smoller, {Jordan W.} and Benson Mwangi and Soares, {Jair C.} and Wu, {Mon Ju} and Zunta-Soares, {Giovana B.} and Jackowski, {Andrea P.} and Pan, {Pedro M.} and Salum, {Giovanni A.} and Michal Assaf and Diefenbach, {Gretchen J.} and Paolo Brambilla and Eleonora Maggioni and David Hofmann and Thomas Straube and Carmen Andreescu and Rachel Berta and Erica Tamburo and Rebecca Price and Manfro, {Gisele G.} and Critchley, {Hugo D.} and Elena Makovac and Matteo Mancini and Frances Meeten and Cristina Ottaviani and Federica Agosta and Elisa Canu and Camilla Cividini and Massimo Filippi and Milutin Kosti{\'c} and Ana Munjiza and Filippi, {Courtney A.} and Ellen Leibenluft and Alberton, {Bianca A.V.} and Balderston, {Nicholas L.} and Monique Ernst and Christian Grillon and Mujica-Parodi, {Lilianne R.} and {van Nieuwenhuizen}, Helena and Fonzo, {Gregory A.} and Paulus, {Martin P.} and Stein, {Murray B.} and Gur, {Raquel E.} and Gur, {Ruben C.} and Kaczkurkin, {Antonia N.} and Bart Larsen and Satterthwaite, {Theodore D.} and Jennifer Harper and Michael Myers and Perino, {Michael T.} and Qiongru Yu and Sylvester, {Chad M.} and Veltman, {Dick J.} and Ulrike Lueken and {Van der Wee}, {Nic J.A.} and Stein, {Dan J.} and Neda Jahanshad and Thompson, {Paul M.} and Pine, {Daniel S.} and Winkler, {Anderson M.}",

note = "Funding Information: Fondazione Cariplo, Grant/Award Number: 2016‐0908; Hartford HealthCare Research Funding Initiative, Grant/Award Number: #129522; Federal Ministry of Education and Research, Grant/Award Numbers: 01ZZ0403, 01ZZ0103, 01ZZ9603, 01ER1703, 01ER1303; National Institutes of Health (NIH), Grant/Award Numbers: K23MH109983, T32MH100019, R01MH101486, U54‐EB020403, ZIA‐MH002782, ZIA‐MH002781 Funding information Funding Information: Paul M. Thompson received partial grant support from Biogen, Inc., (Boston, MA) for research unrelated to this manuscript. Anderson M. Winkler received in the past support from the Government of Brazil through the Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (CNPq: 211534/2013–7). Straube was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), Projects C07/C08, SFB‐TRR 58. Dan J. Stein has received research grants and/or honoraria from Lundbeck and Sun. Hans J. Grabe has received travel grants and speakers honoraria from Fresenius Medical Care, Neuraxpharm, Servier, and Janssen Cilag as well as research funding from Fresenius Medical Care. Funding Information: The authors thank all the many research sites worldwide who considered contributing data to the ENIGMA‐Anxiety/GAD project. Andr{\'e} Zugman, Anita Harrewijn, Elise M. Cardinale, Hannah Zwiebel, Gabrielle F. Freitag, Daniel S. Pine, and Anderson M. Winkler are supported by NIH through ZIA‐MH002781 and ZIA‐MH002782. Paul M. Thompson is supported in part by NIH grant U54‐EB020403. Katy E. Werwath received support from the NIH Office of Intramural Training and Education (OITE). Nynke A. Groenewold was supported by a Claude Leon Postdoctoral Fellowship. Nick J. A. Van der Wee and Dan J. Stein are supported by the EU 7th Framework Marie Curie Actions International Staff Exchange Scheme grant “European and South African Research Network in Anxiety Disorders” (EUSARNAD). Dan J. Stein is supported by the SA Medical Research Council. Ulrike Lueken was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), Projektnummer 44541416, TRR 58. Katja Beesdo‐Baum was supported by the Federal Ministry of Education and Research (BMBF, grants 01ER1303 & 01ER1703). SHIP (Study of Health in Pomerania) is part of the Community Medicine Research net of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research (grants no. 01ZZ9603, 01ZZ0103, and 01ZZ0403), the Ministry of Cultural Affairs and the Social Ministry of the Federal State of Mecklenburg‐West Pomerania; MRI scans in SHIP have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg‐West Pomerania. Jared A. Nielsen, Randy Buckner, and Jordan W. Smoller were supported by NIH grant R01MH101486. Gretchen Diefenbach and Michal Assaf received support from the Hartford HealthCare Research Funding Initiative grant (#129522). Eleonora Maggioni received support from Fondazione Cariplo, grant n° 2016‐0908. Michael Perino received support from NIH grant T32MH100019 (Developmental Neuroscience and Child Psychopathology). Chad M. Sylvester received support from NIH grant K23MH109983. Funding Information: The authors thank all the many research sites worldwide who considered contributing data to the ENIGMA-Anxiety/GAD project. Andr{\'e} Zugman, Anita Harrewijn, Elise M. Cardinale, Hannah Zwiebel, Gabrielle F. Freitag, Daniel S. Pine, and Anderson M. Winkler are supported by NIH through ZIA-MH002781 and ZIA-MH002782. Paul M. Thompson is supported in part by NIH grant U54-EB020403. Katy E. Werwath received support from the NIH Office of Intramural Training and Education (OITE). Nynke A. Groenewold was supported by a Claude Leon Postdoctoral Fellowship. Nick J. A. Van der Wee and Dan J. Stein are supported by the EU 7th Framework Marie Curie Actions International Staff Exchange Scheme grant “European and South African Research Network in Anxiety Disorders” (EUSARNAD). Dan J. Stein is supported by the SA Medical Research Council. Ulrike Lueken was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), Projektnummer 44541416, TRR 58. Katja Beesdo-Baum was supported by the Federal Ministry of Education and Research (BMBF, grants 01ER1303 & 01ER1703). SHIP (Study of Health in Pomerania) is part of the Community Medicine Research net of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research (grants no. 01ZZ9603, 01ZZ0103, and 01ZZ0403), the Ministry of Cultural Affairs and the Social Ministry of the Federal State of Mecklenburg-West Pomerania; MRI scans in SHIP have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania. Jared A. Nielsen, Randy Buckner, and Jordan W. Smoller were supported by NIH grant R01MH101486. Gretchen Diefenbach and Michal Assaf received support from the Hartford HealthCare Research Funding Initiative grant (#129522). Eleonora Maggioni received support from Fondazione Cariplo, grant n° 2016-0908. Michael Perino received support from NIH grant T32MH100019 (Developmental Neuroscience and Child Psychopathology). Chad M. Sylvester received support from NIH grant K23MH109983. Publisher Copyright: {\textcopyright} 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.",

year = "2022",

month = jan,

doi = "10.1002/hbm.25096",

language = "English",

volume = "43",

pages = "255--277",

journal = "Human Brain Mapping",

issn = "1065-9471",

publisher = "Wiley-Liss Inc.",

number = "1",

}

Zugman, A, Harrewijn, A, Cardinale, EM, Zwiebel, H, Freitag, GF, Werwath, KE, Bas-Hoogendam, JM, Groenewold, NA, Aghajani, M, Hilbert, K, Cardoner, N, Porta-Casteràs, D, Gosnell, S, Salas, R, Blair, KS, Blair, JR, Hammoud, MZ, Milad, M, Burkhouse, K, Phan, KL, Schroeder, HK, Strawn, JR, Beesdo-Baum, K, Thomopoulos, SI, Grabe, HJ, Van der Auwera, S, Wittfeld, K, Nielsen, JA, Buckner, R, Smoller, JW, Mwangi, B, Soares, JC, Wu, MJ, Zunta-Soares, GB, Jackowski, AP, Pan, PM, Salum, GA, Assaf, M, Diefenbach, GJ, Brambilla, P, Maggioni, E, Hofmann, D, Straube, T, Andreescu, C, Berta, R, Tamburo, E, Price, R, Manfro, GG, Critchley, HD, Makovac, E, Mancini, M, Meeten, F, Ottaviani, C, Agosta, F, Canu, E, Cividini, C, Filippi, M, Kostić, M, Munjiza, A, Filippi, CA, Leibenluft, E, Alberton, BAV, Balderston, NL, Ernst, M, Grillon, C, Mujica-Parodi, LR, van Nieuwenhuizen, H, Fonzo, GA, Paulus, MP, Stein, MB, Gur, RE, Gur, RC, Kaczkurkin, AN, Larsen, B, Satterthwaite, TD, Harper, J, Myers, M, Perino, MT, Yu, Q, Sylvester, CM, Veltman, DJ, Lueken, U, Van der Wee, NJA, Stein, DJ, Jahanshad, N, Thompson, PM, Pine, DS & Winkler, AM 2022, 'Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group', Human Brain Mapping, vol. 43, no. 1, pp. 255-277. https://doi.org/10.1002/hbm.25096

TY - JOUR

T1 - Mega-analysis methods in ENIGMA

T2 - The experience of the generalized anxiety disorder working group

AU - Zugman, André

AU - Harrewijn, Anita

AU - Cardinale, Elise M.

AU - Zwiebel, Hannah

AU - Freitag, Gabrielle F.

AU - Werwath, Katy E.

AU - Bas-Hoogendam, Janna M.

AU - Groenewold, Nynke A.

AU - Aghajani, Moji

AU - Hilbert, Kevin

AU - Cardoner, Narcis

AU - Porta-Casteràs, Daniel

AU - Gosnell, Savannah

AU - Salas, Ramiro

AU - Blair, Karina S.

AU - Blair, James R.

AU - Hammoud, Mira Z.

AU - Milad, Mohammed

AU - Burkhouse, Katie

AU - Phan, K. Luan

AU - Schroeder, Heidi K.

AU - Strawn, Jeffrey R.

AU - Beesdo-Baum, Katja

AU - Thomopoulos, Sophia I.

AU - Grabe, Hans J.

AU - Van der Auwera, Sandra

AU - Wittfeld, Katharina

AU - Nielsen, Jared A.

AU - Buckner, Randy

AU - Smoller, Jordan W.

AU - Mwangi, Benson

AU - Soares, Jair C.

AU - Wu, Mon Ju

AU - Zunta-Soares, Giovana B.

AU - Jackowski, Andrea P.

AU - Pan, Pedro M.

AU - Salum, Giovanni A.

AU - Assaf, Michal

AU - Diefenbach, Gretchen J.

AU - Brambilla, Paolo

AU - Maggioni, Eleonora

AU - Hofmann, David

AU - Straube, Thomas

AU - Andreescu, Carmen

AU - Berta, Rachel

AU - Tamburo, Erica

AU - Price, Rebecca

AU - Manfro, Gisele G.

AU - Critchley, Hugo D.

AU - Makovac, Elena

AU - Mancini, Matteo

AU - Meeten, Frances

AU - Ottaviani, Cristina

AU - Agosta, Federica

AU - Canu, Elisa

AU - Cividini, Camilla

AU - Filippi, Massimo

AU - Kostić, Milutin

AU - Munjiza, Ana

AU - Filippi, Courtney A.

AU - Leibenluft, Ellen

AU - Alberton, Bianca A.V.

AU - Balderston, Nicholas L.

AU - Ernst, Monique

AU - Grillon, Christian

AU - Mujica-Parodi, Lilianne R.

AU - van Nieuwenhuizen, Helena

AU - Fonzo, Gregory A.

AU - Paulus, Martin P.

AU - Stein, Murray B.

AU - Gur, Raquel E.

AU - Gur, Ruben C.

AU - Kaczkurkin, Antonia N.

AU - Larsen, Bart

AU - Satterthwaite, Theodore D.

AU - Harper, Jennifer

AU - Myers, Michael

AU - Perino, Michael T.

AU - Yu, Qiongru

AU - Sylvester, Chad M.

AU - Veltman, Dick J.

AU - Lueken, Ulrike

AU - Van der Wee, Nic J.A.

AU - Stein, Dan J.

AU - Jahanshad, Neda

AU - Thompson, Paul M.

AU - Pine, Daniel S.

AU - Winkler, Anderson M.

N1 - Funding Information: Fondazione Cariplo, Grant/Award Number: 2016‐0908; Hartford HealthCare Research Funding Initiative, Grant/Award Number: #129522; Federal Ministry of Education and Research, Grant/Award Numbers: 01ZZ0403, 01ZZ0103, 01ZZ9603, 01ER1703, 01ER1303; National Institutes of Health (NIH), Grant/Award Numbers: K23MH109983, T32MH100019, R01MH101486, U54‐EB020403, ZIA‐MH002782, ZIA‐MH002781 Funding information Funding Information: Paul M. Thompson received partial grant support from Biogen, Inc., (Boston, MA) for research unrelated to this manuscript. Anderson M. Winkler received in the past support from the Government of Brazil through the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq: 211534/2013–7). Straube was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), Projects C07/C08, SFB‐TRR 58. Dan J. Stein has received research grants and/or honoraria from Lundbeck and Sun. Hans J. Grabe has received travel grants and speakers honoraria from Fresenius Medical Care, Neuraxpharm, Servier, and Janssen Cilag as well as research funding from Fresenius Medical Care. Funding Information: The authors thank all the many research sites worldwide who considered contributing data to the ENIGMA‐Anxiety/GAD project. André Zugman, Anita Harrewijn, Elise M. Cardinale, Hannah Zwiebel, Gabrielle F. Freitag, Daniel S. Pine, and Anderson M. Winkler are supported by NIH through ZIA‐MH002781 and ZIA‐MH002782. Paul M. Thompson is supported in part by NIH grant U54‐EB020403. Katy E. Werwath received support from the NIH Office of Intramural Training and Education (OITE). Nynke A. Groenewold was supported by a Claude Leon Postdoctoral Fellowship. Nick J. A. Van der Wee and Dan J. Stein are supported by the EU 7th Framework Marie Curie Actions International Staff Exchange Scheme grant “European and South African Research Network in Anxiety Disorders” (EUSARNAD). Dan J. Stein is supported by the SA Medical Research Council. Ulrike Lueken was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), Projektnummer 44541416, TRR 58. Katja Beesdo‐Baum was supported by the Federal Ministry of Education and Research (BMBF, grants 01ER1303 & 01ER1703). SHIP (Study of Health in Pomerania) is part of the Community Medicine Research net of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research (grants no. 01ZZ9603, 01ZZ0103, and 01ZZ0403), the Ministry of Cultural Affairs and the Social Ministry of the Federal State of Mecklenburg‐West Pomerania; MRI scans in SHIP have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg‐West Pomerania. Jared A. Nielsen, Randy Buckner, and Jordan W. Smoller were supported by NIH grant R01MH101486. Gretchen Diefenbach and Michal Assaf received support from the Hartford HealthCare Research Funding Initiative grant (#129522). Eleonora Maggioni received support from Fondazione Cariplo, grant n° 2016‐0908. Michael Perino received support from NIH grant T32MH100019 (Developmental Neuroscience and Child Psychopathology). Chad M. Sylvester received support from NIH grant K23MH109983. Funding Information: The authors thank all the many research sites worldwide who considered contributing data to the ENIGMA-Anxiety/GAD project. André Zugman, Anita Harrewijn, Elise M. Cardinale, Hannah Zwiebel, Gabrielle F. Freitag, Daniel S. Pine, and Anderson M. Winkler are supported by NIH through ZIA-MH002781 and ZIA-MH002782. Paul M. Thompson is supported in part by NIH grant U54-EB020403. Katy E. Werwath received support from the NIH Office of Intramural Training and Education (OITE). Nynke A. Groenewold was supported by a Claude Leon Postdoctoral Fellowship. Nick J. A. Van der Wee and Dan J. Stein are supported by the EU 7th Framework Marie Curie Actions International Staff Exchange Scheme grant “European and South African Research Network in Anxiety Disorders” (EUSARNAD). Dan J. Stein is supported by the SA Medical Research Council. Ulrike Lueken was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), Projektnummer 44541416, TRR 58. Katja Beesdo-Baum was supported by the Federal Ministry of Education and Research (BMBF, grants 01ER1303 & 01ER1703). SHIP (Study of Health in Pomerania) is part of the Community Medicine Research net of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research (grants no. 01ZZ9603, 01ZZ0103, and 01ZZ0403), the Ministry of Cultural Affairs and the Social Ministry of the Federal State of Mecklenburg-West Pomerania; MRI scans in SHIP have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania. Jared A. Nielsen, Randy Buckner, and Jordan W. Smoller were supported by NIH grant R01MH101486. Gretchen Diefenbach and Michal Assaf received support from the Hartford HealthCare Research Funding Initiative grant (#129522). Eleonora Maggioni received support from Fondazione Cariplo, grant n° 2016-0908. Michael Perino received support from NIH grant T32MH100019 (Developmental Neuroscience and Child Psychopathology). Chad M. Sylvester received support from NIH grant K23MH109983. Publisher Copyright: © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.

PY - 2022/1

Y1 - 2022/1

N2 - The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega-analyses.

AB - The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega-analyses.

KW - data sharing

KW - generalized anxiety disorder

KW - mega-analyses

KW - meta-analyses

KW - neuroimaging

UR - http://www.scopus.com/inward/record.url?scp=85083703055&partnerID=8YFLogxK

U2 - 10.1002/hbm.25096

DO - 10.1002/hbm.25096

M3 - Review article

C2 - 32596977

AN - SCOPUS:85083703055

SN - 1065-9471

VL - 43

SP - 255

EP - 277

JO - Human Brain Mapping

JF - Human Brain Mapping

IS - 1

ER -

Mega-analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group

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Keywords

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