Memantine as a neuroprotective agent in early stages of psychosis

TY - JOUR

T1 - Memantine as a neuroprotective agent in early stages of psychosis

AU - Fusar-Poli, Paolo

AU - Pellegrini, Francesco

AU - Cortesi, Mariachiara

PY - 2006

Y1 - 2006

N2 - A growing body of evidence has clearly indicated that neurocognitive deficits such as verbal learning and memory, speed of processing, attention/vigilance, language skills and executive functions are a core feature in the early stages of schizophrenia [1]. These dysfunction domains are reliable predictors of long-term disability and treatment outcome and are presently viewed as crucial targets for new pharmacological treatments of schizophrenia [2]. Although the neurophysiological correlates of cognitive impairment in early stage of psychosis are not completely clear, excitotoxic (glutamate-related) cell injury and neuronal death have been hypothesised to play a crucial role [3].

AB - A growing body of evidence has clearly indicated that neurocognitive deficits such as verbal learning and memory, speed of processing, attention/vigilance, language skills and executive functions are a core feature in the early stages of schizophrenia [1]. These dysfunction domains are reliable predictors of long-term disability and treatment outcome and are presently viewed as crucial targets for new pharmacological treatments of schizophrenia [2]. Although the neurophysiological correlates of cognitive impairment in early stage of psychosis are not completely clear, excitotoxic (glutamate-related) cell injury and neuronal death have been hypothesised to play a crucial role [3].

U2 - 10.1016/j.mehy.2006.07.026

DO - 10.1016/j.mehy.2006.07.026

M3 - Article

VL - 68

SP - 459

EP - 460

JO - Medical Hypotheses

JF - Medical Hypotheses

IS - 2

ER -