Membrane protein folding

P J Booth; A R Curran

Membrane protein folding

P J Booth, A R Curran

Chemistry

Research output: Contribution to journal › Article › peer-review

96 Citations (Scopus)

Abstract

Investigating the in vitro refolding of proteins that naturally reside in biological membranes is a notoriously difficult task. Biophysical studies on model systems are beginning to provide a sound physical basis for membrane protein folding that should help to alleviate this problem. Highlights of these studies include insights into the interaction of transmembrane alpha helices, as well as into the important role that membrane lipids play in folding.

Original language	English
Pages (from-to)	115-21
Number of pages	7
Journal	Current Opinion in Structural Biology
Volume	9
Issue number	1
Publication status	Published - Feb 1999

Keywords

Bacteriorhodopsins
Biophysical Phenomena
Biophysics
Carrier Proteins
In Vitro Techniques
Ion Channels
Membrane Lipids
Membrane Proteins
Models, Molecular
Protein Folding
Protein Structure, Secondary
Receptors, Cell Surface

Cite this

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title = "Membrane protein folding",

abstract = "Investigating the in vitro refolding of proteins that naturally reside in biological membranes is a notoriously difficult task. Biophysical studies on model systems are beginning to provide a sound physical basis for membrane protein folding that should help to alleviate this problem. Highlights of these studies include insights into the interaction of transmembrane alpha helices, as well as into the important role that membrane lipids play in folding.",

keywords = "Bacteriorhodopsins, Biophysical Phenomena, Biophysics, Carrier Proteins, In Vitro Techniques, Ion Channels, Membrane Lipids, Membrane Proteins, Models, Molecular, Protein Folding, Protein Structure, Secondary, Receptors, Cell Surface",

author = "Booth, {P J} and Curran, {A R}",

year = "1999",

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language = "English",

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journal = "Current Opinion in Structural Biology",

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TY - JOUR

T1 - Membrane protein folding

AU - Booth, P J

AU - Curran, A R

PY - 1999/2

Y1 - 1999/2

N2 - Investigating the in vitro refolding of proteins that naturally reside in biological membranes is a notoriously difficult task. Biophysical studies on model systems are beginning to provide a sound physical basis for membrane protein folding that should help to alleviate this problem. Highlights of these studies include insights into the interaction of transmembrane alpha helices, as well as into the important role that membrane lipids play in folding.

AB - Investigating the in vitro refolding of proteins that naturally reside in biological membranes is a notoriously difficult task. Biophysical studies on model systems are beginning to provide a sound physical basis for membrane protein folding that should help to alleviate this problem. Highlights of these studies include insights into the interaction of transmembrane alpha helices, as well as into the important role that membrane lipids play in folding.

KW - Bacteriorhodopsins

KW - Biophysical Phenomena

KW - Biophysics

KW - Carrier Proteins

KW - In Vitro Techniques

KW - Ion Channels

KW - Membrane Lipids

KW - Membrane Proteins

KW - Models, Molecular

KW - Protein Folding

KW - Protein Structure, Secondary

KW - Receptors, Cell Surface

M3 - Article

C2 - 10047580

SN - 0959-440X

VL - 9

SP - 115

EP - 121

JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

IS - 1

ER -

Membrane protein folding

Abstract

Keywords

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