Menopause is associated with postprandial metabolism, metabolic health and lifestyle: The ZOE PREDICT study

Kate M. Bermingham; Inbar Linenberg; Wendy l. Hall; Kirstin Kadé; Paul w. Franks; Richard Davies; Jonathan Wolf; George Hadjigeorgiou; Francesco Asnicar; Nicola Segata; Joann e. Manson; Louise r. Newson; Linda m. Delahanty; Jose m. Ordovas; Andrew t. Chan; Tim d. Spector; Ana m. Valdes; Sarah e. Berry

doi:10.1016/j.ebiom.2022.104303

Menopause is associated with postprandial metabolism, metabolic health and lifestyle: The ZOE PREDICT study

Kate M. Bermingham, Inbar Linenberg, Wendy l. Hall, Kirstin Kadé, Paul w. Franks, Richard Davies, Jonathan Wolf, George Hadjigeorgiou, Francesco Asnicar, Nicola Segata, Joann e. Manson, Louise r. Newson, Linda m. Delahanty, Jose m. Ordovas, Andrew t. Chan, Tim d. Spector, Ana m. Valdes, Sarah e. Berry

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Abstract

Background
The menopause transition is associated with unfavourable alterations in health. However, postprandial metabolic changes and their mediating factors are poorly understood.
Methods
The PREDICT 1 UK cohort (n=1002; pre- n=366, peri- n=55, and post-menopausal females n=206) assessed phenotypic characteristics, anthropometric, diet and gut microbiome data, and fasting and postprandial (0–6 h) cardiometabolic blood measurements, including continuous glucose monitoring (CGM) data. Differences between menopausal groups were assessed in the cohort and in an age-matched subgroup, adjusting for age, BMI, menopausal hormone therapy (MHT) use, and smoking status.
Findings
Post-menopausal females had higher fasting blood measures (glucose, HbA1c and inflammation (GlycA), 6%, 5% and 4% respectively), sugar intakes (12%) and poorer sleep (12%) compared with pre-menopausal females (pInterpretation
Findings from this large scale, in-depth nutrition metabolic study of menopause, support the importance of monitoring risk factors for type-2 diabetes and cardiovascular disease in mid-life to older women to reduce morbidity and mortality associated with oestrogen decline.
Funding
Zoe Ltd.

Original language	English
Number of pages	104303
Journal	EBioMedicine
Volume	85
Early online date	18 Oct 2022
DOIs	https://doi.org/10.1016/j.ebiom.2022.104303
Publication status	Published - Nov 2022

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Bermingham, K. M., Linenberg, I., Hall, W. L., Kadé, K., Franks, P. W., Davies, R., Wolf, J., Hadjigeorgiou, G., Asnicar, F., Segata, N., Manson, J. E., Newson, L. R., Delahanty, L. M., Ordovas, J. M., Chan, A. T., Spector, T. D., Valdes, A. M., & Berry, S. E. (2022). Menopause is associated with postprandial metabolism, metabolic health and lifestyle: The ZOE PREDICT study. EBioMedicine, 85. https://doi.org/10.1016/j.ebiom.2022.104303

@article{d41ef54d5ae14e77bbfda7aca913c40b,

title = "Menopause is associated with postprandial metabolism, metabolic health and lifestyle: The ZOE PREDICT study",

abstract = "BackgroundThe menopause transition is associated with unfavourable alterations in health. However, postprandial metabolic changes and their mediating factors are poorly understood.MethodsThe PREDICT 1 UK cohort (n=1002; pre- n=366, peri- n=55, and post-menopausal females n=206) assessed phenotypic characteristics, anthropometric, diet and gut microbiome data, and fasting and postprandial (0–6 h) cardiometabolic blood measurements, including continuous glucose monitoring (CGM) data. Differences between menopausal groups were assessed in the cohort and in an age-matched subgroup, adjusting for age, BMI, menopausal hormone therapy (MHT) use, and smoking status.FindingsPost-menopausal females had higher fasting blood measures (glucose, HbA1c and inflammation (GlycA), 6%, 5% and 4% respectively), sugar intakes (12%) and poorer sleep (12%) compared with pre-menopausal females (pInterpretationFindings from this large scale, in-depth nutrition metabolic study of menopause, support the importance of monitoring risk factors for type-2 diabetes and cardiovascular disease in mid-life to older women to reduce morbidity and mortality associated with oestrogen decline.FundingZoe Ltd.",

author = "Bermingham, {Kate M.} and Inbar Linenberg and Hall, {Wendy l.} and Kirstin Kad{\'e} and Franks, {Paul w.} and Richard Davies and Jonathan Wolf and George Hadjigeorgiou and Francesco Asnicar and Nicola Segata and Manson, {Joann e.} and Newson, {Louise r.} and Delahanty, {Linda m.} and Ordovas, {Jose m.} and Chan, {Andrew t.} and Spector, {Tim d.} and Valdes, {Ana m.} and Berry, {Sarah e.}",

year = "2022",

month = nov,

doi = "10.1016/j.ebiom.2022.104303",

language = "English",

volume = "85",

journal = "EBioMedicine",

issn = "2352-3964",

publisher = "Elsevier BV",

}

Bermingham, KM , Linenberg, I , Hall, WL, Kadé, K, Franks, PW, Davies, R, Wolf, J, Hadjigeorgiou, G, Asnicar, F, Segata, N, Manson, JE, Newson, LR, Delahanty, LM, Ordovas, JM, Chan, AT, Spector, TD , Valdes, AM & Berry, SE 2022, 'Menopause is associated with postprandial metabolism, metabolic health and lifestyle: The ZOE PREDICT study', EBioMedicine, vol. 85. https://doi.org/10.1016/j.ebiom.2022.104303

TY - JOUR

T1 - Menopause is associated with postprandial metabolism, metabolic health and lifestyle: The ZOE PREDICT study

AU - Bermingham, Kate M.

AU - Linenberg, Inbar

AU - Hall, Wendy l.

AU - Kadé, Kirstin

AU - Franks, Paul w.

AU - Davies, Richard

AU - Wolf, Jonathan

AU - Hadjigeorgiou, George

AU - Asnicar, Francesco

AU - Segata, Nicola

AU - Manson, Joann e.

AU - Newson, Louise r.

AU - Delahanty, Linda m.

AU - Ordovas, Jose m.

AU - Chan, Andrew t.

AU - Spector, Tim d.

AU - Valdes, Ana m.

AU - Berry, Sarah e.

PY - 2022/11

Y1 - 2022/11

N2 - BackgroundThe menopause transition is associated with unfavourable alterations in health. However, postprandial metabolic changes and their mediating factors are poorly understood.MethodsThe PREDICT 1 UK cohort (n=1002; pre- n=366, peri- n=55, and post-menopausal females n=206) assessed phenotypic characteristics, anthropometric, diet and gut microbiome data, and fasting and postprandial (0–6 h) cardiometabolic blood measurements, including continuous glucose monitoring (CGM) data. Differences between menopausal groups were assessed in the cohort and in an age-matched subgroup, adjusting for age, BMI, menopausal hormone therapy (MHT) use, and smoking status.FindingsPost-menopausal females had higher fasting blood measures (glucose, HbA1c and inflammation (GlycA), 6%, 5% and 4% respectively), sugar intakes (12%) and poorer sleep (12%) compared with pre-menopausal females (pInterpretationFindings from this large scale, in-depth nutrition metabolic study of menopause, support the importance of monitoring risk factors for type-2 diabetes and cardiovascular disease in mid-life to older women to reduce morbidity and mortality associated with oestrogen decline.FundingZoe Ltd.

AB - BackgroundThe menopause transition is associated with unfavourable alterations in health. However, postprandial metabolic changes and their mediating factors are poorly understood.MethodsThe PREDICT 1 UK cohort (n=1002; pre- n=366, peri- n=55, and post-menopausal females n=206) assessed phenotypic characteristics, anthropometric, diet and gut microbiome data, and fasting and postprandial (0–6 h) cardiometabolic blood measurements, including continuous glucose monitoring (CGM) data. Differences between menopausal groups were assessed in the cohort and in an age-matched subgroup, adjusting for age, BMI, menopausal hormone therapy (MHT) use, and smoking status.FindingsPost-menopausal females had higher fasting blood measures (glucose, HbA1c and inflammation (GlycA), 6%, 5% and 4% respectively), sugar intakes (12%) and poorer sleep (12%) compared with pre-menopausal females (pInterpretationFindings from this large scale, in-depth nutrition metabolic study of menopause, support the importance of monitoring risk factors for type-2 diabetes and cardiovascular disease in mid-life to older women to reduce morbidity and mortality associated with oestrogen decline.FundingZoe Ltd.

U2 - 10.1016/j.ebiom.2022.104303

DO - 10.1016/j.ebiom.2022.104303

M3 - Article

SN - 2352-3964

VL - 85

JO - EBioMedicine

JF - EBioMedicine

ER -

Menopause is associated with postprandial metabolism, metabolic health and lifestyle: The ZOE PREDICT study

Abstract

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