Menopause is associated with postprandial metabolism, metabolic health and lifestyle: The ZOE PREDICT study

Kate M. Bermingham, Inbar Linenberg, Wendy l. Hall, Kirstin Kadé, Paul w. Franks, Richard Davies, Jonathan Wolf, George Hadjigeorgiou, Francesco Asnicar, Nicola Segata, Joann e. Manson, Louise r. Newson, Linda m. Delahanty, Jose m. Ordovas, Andrew t. Chan, Tim d. Spector, Ana m. Valdes, Sarah e. Berry

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Background
The menopause transition is associated with unfavourable alterations in health. However, postprandial metabolic changes and their mediating factors are poorly understood.
Methods
The PREDICT 1 UK cohort (n=1002; pre- n=366, peri- n=55, and post-menopausal females n=206) assessed phenotypic characteristics, anthropometric, diet and gut microbiome data, and fasting and postprandial (0–6 h) cardiometabolic blood measurements, including continuous glucose monitoring (CGM) data. Differences between menopausal groups were assessed in the cohort and in an age-matched subgroup, adjusting for age, BMI, menopausal hormone therapy (MHT) use, and smoking status.
Findings
Post-menopausal females had higher fasting blood measures (glucose, HbA1c and inflammation (GlycA), 6%, 5% and 4% respectively), sugar intakes (12%) and poorer sleep (12%) compared with pre-menopausal females (pInterpretation
Findings from this large scale, in-depth nutrition metabolic study of menopause, support the importance of monitoring risk factors for type-2 diabetes and cardiovascular disease in mid-life to older women to reduce morbidity and mortality associated with oestrogen decline.
Funding
Zoe Ltd.
Original languageEnglish
Number of pages104303
JournalEBioMedicine
Volume85
Early online date18 Oct 2022
DOIs
Publication statusPublished - Nov 2022

Fingerprint

Dive into the research topics of 'Menopause is associated with postprandial metabolism, metabolic health and lifestyle: The ZOE PREDICT study'. Together they form a unique fingerprint.

Cite this