Mental wellbeing and quality of life in prostate cancer (MIND-P): Protocol for a multi-institutional prospective cohort study

Oliver Brunckhorst; Jaroslaw Liszka; Callum James; Jack Fanshawe; Mohamed Y Hammadeh; Robert Thomas; Shahid Khan; Matin Sheriff; Hashim U. Ahmed; Mieke Van Hemelrijck; Gordon Muir; Robert Stewart; Prokar Dasgupta; Kamran Ahmed

doi:10.1371/journal.pone.0284727

Mental wellbeing and quality of life in prostate cancer (MIND-P): Protocol for a multi-institutional prospective cohort study

Oliver Brunckhorst^*, Jaroslaw Liszka, Callum James, Jack Fanshawe, Mohamed Y Hammadeh, Robert Thomas, Shahid Khan, Matin Sheriff , Hashim U. Ahmed, Mieke Van Hemelrijck, Gordon Muir, Robert Stewart, Prokar Dasgupta, Kamran Ahmed

^*Corresponding author for this work

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Abstract

Background The mental wellbeing implications of a prostate cancer diagnosis are increasingly being realised. Significant mental health symptoms such as depression and anxiety, along with related constructs such as fear of cancer recurrence, body image and masculine self-esteem issues are prevalent. However, less is understood about potential prognostic factors for these outcomes in prostate cancer patients. Therefore, this study aims to primarily explore potential treatment, patient and oncological factors associated with mental wellbeing outcomes in the initial prostate cancer follow-up period. Methods MIND-P is a multi-institutional prospective cohort study recruiting newly diagnosed prostate cancer patients for 12-month follow up. It will aim to recruit a final sample of 300 participants undergoing one of four treatment options: active surveillance, radical prostatectomy, radical radiotherapy, or hormone monotherapy. Questionnaire-based data collection consists of multiple validated mental, physical, and social wellbeing outcomes at baseline and 3- monthly intervals until study completion. Primary analysis will include evaluation of treatment undergone against multiple mental wellbeing outcomes. Secondary analysis will additionally explore multiple patient and oncological prognostic factors of potential importance, along with the cumulative incidence of these outcomes, symptom trajectory and their association with subsequent functional and social outcomes. Conclusion This cohort study aims to add to the existing limited literature evaluating significant prognostic factors for multiple mental wellbeing outcomes in newly diagnosed prostate cancer patients. This may be of potential use for guiding future prognosis research and of clinical use for identifying individuals potentially requiring additional surveillance or support during routine cancer follow up.

Original language	English
Article number	e0284727
Journal	PLoS One
Volume	18
Issue number	4 April
Early online date	24 Apr 2023
DOIs	https://doi.org/10.1371/journal.pone.0284727
Publication status	E-pub ahead of print - 24 Apr 2023

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journal.pone.0284727Final published version, 953 KBLicence: CC BY

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Brunckhorst, O., Liszka, J., James, C., Fanshawe, J., Hammadeh, M. Y., Thomas, R., Khan, S., Sheriff , M., Ahmed, H. U., Van Hemelrijck, M., Muir, G., Stewart, R., Dasgupta, P., & Ahmed, K. (2023). Mental wellbeing and quality of life in prostate cancer (MIND-P): Protocol for a multi-institutional prospective cohort study. PLoS One, 18(4 April), Article e0284727. Advance online publication. https://doi.org/10.1371/journal.pone.0284727

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title = "Mental wellbeing and quality of life in prostate cancer (MIND-P): Protocol for a multi-institutional prospective cohort study",

abstract = "Background The mental wellbeing implications of a prostate cancer diagnosis are increasingly being realised. Significant mental health symptoms such as depression and anxiety, along with related constructs such as fear of cancer recurrence, body image and masculine self-esteem issues are prevalent. However, less is understood about potential prognostic factors for these outcomes in prostate cancer patients. Therefore, this study aims to primarily explore potential treatment, patient and oncological factors associated with mental wellbeing outcomes in the initial prostate cancer follow-up period. Methods MIND-P is a multi-institutional prospective cohort study recruiting newly diagnosed prostate cancer patients for 12-month follow up. It will aim to recruit a final sample of 300 participants undergoing one of four treatment options: active surveillance, radical prostatectomy, radical radiotherapy, or hormone monotherapy. Questionnaire-based data collection consists of multiple validated mental, physical, and social wellbeing outcomes at baseline and 3- monthly intervals until study completion. Primary analysis will include evaluation of treatment undergone against multiple mental wellbeing outcomes. Secondary analysis will additionally explore multiple patient and oncological prognostic factors of potential importance, along with the cumulative incidence of these outcomes, symptom trajectory and their association with subsequent functional and social outcomes. Conclusion This cohort study aims to add to the existing limited literature evaluating significant prognostic factors for multiple mental wellbeing outcomes in newly diagnosed prostate cancer patients. This may be of potential use for guiding future prognosis research and of clinical use for identifying individuals potentially requiring additional surveillance or support during routine cancer follow up.",

author = "Oliver Brunckhorst and Jaroslaw Liszka and Callum James and Jack Fanshawe and Hammadeh, {Mohamed Y} and Robert Thomas and Shahid Khan and Matin Sheriff and Ahmed, {Hashim U.} and {Van Hemelrijck}, Mieke and Gordon Muir and Robert Stewart and Prokar Dasgupta and Kamran Ahmed",

note = "Publisher Copyright: {\textcopyright} 2023 Brunckhorst et al.",

year = "2023",

month = apr,

day = "24",

doi = "10.1371/journal.pone.0284727",

language = "English",

volume = "18",

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Brunckhorst, O, Liszka, J, James, C, Fanshawe, J, Hammadeh, MY, Thomas, R, Khan, S, Sheriff , M, Ahmed, HU, Van Hemelrijck, M, Muir, G, Stewart, R , Dasgupta, P & Ahmed, K 2023, 'Mental wellbeing and quality of life in prostate cancer (MIND-P): Protocol for a multi-institutional prospective cohort study', PLoS One, vol. 18, no. 4 April, e0284727. https://doi.org/10.1371/journal.pone.0284727

TY - JOUR

T1 - Mental wellbeing and quality of life in prostate cancer (MIND-P)

T2 - Protocol for a multi-institutional prospective cohort study

AU - Brunckhorst, Oliver

AU - Liszka, Jaroslaw

AU - James, Callum

AU - Fanshawe, Jack

AU - Hammadeh, Mohamed Y

AU - Thomas, Robert

AU - Khan, Shahid

AU - Sheriff , Matin

AU - Ahmed, Hashim U.

AU - Van Hemelrijck, Mieke

AU - Muir, Gordon

AU - Stewart, Robert

AU - Dasgupta, Prokar

AU - Ahmed, Kamran

PY - 2023/4/24

Y1 - 2023/4/24

N2 - Background The mental wellbeing implications of a prostate cancer diagnosis are increasingly being realised. Significant mental health symptoms such as depression and anxiety, along with related constructs such as fear of cancer recurrence, body image and masculine self-esteem issues are prevalent. However, less is understood about potential prognostic factors for these outcomes in prostate cancer patients. Therefore, this study aims to primarily explore potential treatment, patient and oncological factors associated with mental wellbeing outcomes in the initial prostate cancer follow-up period. Methods MIND-P is a multi-institutional prospective cohort study recruiting newly diagnosed prostate cancer patients for 12-month follow up. It will aim to recruit a final sample of 300 participants undergoing one of four treatment options: active surveillance, radical prostatectomy, radical radiotherapy, or hormone monotherapy. Questionnaire-based data collection consists of multiple validated mental, physical, and social wellbeing outcomes at baseline and 3- monthly intervals until study completion. Primary analysis will include evaluation of treatment undergone against multiple mental wellbeing outcomes. Secondary analysis will additionally explore multiple patient and oncological prognostic factors of potential importance, along with the cumulative incidence of these outcomes, symptom trajectory and their association with subsequent functional and social outcomes. Conclusion This cohort study aims to add to the existing limited literature evaluating significant prognostic factors for multiple mental wellbeing outcomes in newly diagnosed prostate cancer patients. This may be of potential use for guiding future prognosis research and of clinical use for identifying individuals potentially requiring additional surveillance or support during routine cancer follow up.

AB - Background The mental wellbeing implications of a prostate cancer diagnosis are increasingly being realised. Significant mental health symptoms such as depression and anxiety, along with related constructs such as fear of cancer recurrence, body image and masculine self-esteem issues are prevalent. However, less is understood about potential prognostic factors for these outcomes in prostate cancer patients. Therefore, this study aims to primarily explore potential treatment, patient and oncological factors associated with mental wellbeing outcomes in the initial prostate cancer follow-up period. Methods MIND-P is a multi-institutional prospective cohort study recruiting newly diagnosed prostate cancer patients for 12-month follow up. It will aim to recruit a final sample of 300 participants undergoing one of four treatment options: active surveillance, radical prostatectomy, radical radiotherapy, or hormone monotherapy. Questionnaire-based data collection consists of multiple validated mental, physical, and social wellbeing outcomes at baseline and 3- monthly intervals until study completion. Primary analysis will include evaluation of treatment undergone against multiple mental wellbeing outcomes. Secondary analysis will additionally explore multiple patient and oncological prognostic factors of potential importance, along with the cumulative incidence of these outcomes, symptom trajectory and their association with subsequent functional and social outcomes. Conclusion This cohort study aims to add to the existing limited literature evaluating significant prognostic factors for multiple mental wellbeing outcomes in newly diagnosed prostate cancer patients. This may be of potential use for guiding future prognosis research and of clinical use for identifying individuals potentially requiring additional surveillance or support during routine cancer follow up.

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U2 - 10.1371/journal.pone.0284727

DO - 10.1371/journal.pone.0284727

M3 - Article

SN - 1932-6203

VL - 18

JO - PLoS One

JF - PLoS One

IS - 4 April

M1 - e0284727

ER -

Mental wellbeing and quality of life in prostate cancer (MIND-P): Protocol for a multi-institutional prospective cohort study

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