Mesenchymal stem cells (MSCs) are found in many adult tissues and organs. In tissues that grow continuously or exhibit high rates of cell turnover, MSCs provide a renewable source of progenitor cells to differentiate and replace those lost. In the majority of tissues, MSCs are found in small numbers and remain quiescent until mobilized in response to tissue damage. The rodent incisor is a continuously growing organ where MSCs provide both growth and repair functions. The location of epithelial stem cell niches in the cervical loops supports the notion that the MSCs are located close to the epithelial stem cells to offer coordination of growth of the tooth. MSC populations that reside in tooth pulp provide an easily accessible cell source. The mouse incisor is an excellent model to study pulp MSCs since it uses MSCs for both growth and repair.
|Title of host publication||Stem Cells in Craniofacial Development and Regeneration|
|Publisher||Wiley Online Library|
|Number of pages||10|
|Publication status||Published - 26 Mar 2013|
- Mesenchymal stem cells (mscs)
- Rodent incisor
- Tooth pulp