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Mesenchymal Stem Cell Niches in Rodent Tooth Pulp

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

George T J Huang, Irma Thesleff, Jifan Feng, Paul T. Sharpe

Original languageEnglish
Title of host publicationStem Cells in Craniofacial Development and Regeneration
PublisherWiley Online Library
Number of pages10
ISBN (Electronic)9781118498026
ISBN (Print)9781118279236
Published26 Mar 2013

King's Authors


Mesenchymal stem cells (MSCs) are found in many adult tissues and organs. In tissues that grow continuously or exhibit high rates of cell turnover, MSCs provide a renewable source of progenitor cells to differentiate and replace those lost. In the majority of tissues, MSCs are found in small numbers and remain quiescent until mobilized in response to tissue damage. The rodent incisor is a continuously growing organ where MSCs provide both growth and repair functions. The location of epithelial stem cell niches in the cervical loops supports the notion that the MSCs are located close to the epithelial stem cells to offer coordination of growth of the tooth. MSC populations that reside in tooth pulp provide an easily accessible cell source. The mouse incisor is an excellent model to study pulp MSCs since it uses MSCs for both growth and repair.

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