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Messing with metabolism: lessons from an IUGR fetes

Research output: Contribution to journalComment/debate

Original languageEnglish
Pages (from-to)15
Number of pages16
JournalThe Journal of Physiology
Publication statusPublished - 2018

King's Authors


A wealth of evidence supports the developmental period as being an important determinant for future health status, as well as life expectancy. Intrauterine growth restriction (IUGR), or failure of the fetus to reach its full growth and developmental potential, can occur for many reasons. Abnormal or insufficiently small placental development can induce IUGR, with the latter often occurring secondary to maternal hypertensive disorders such as pre-eclampsia. During pregnancy the placenta has many roles including providing a functional interface between separate maternal and fetal circulatory systems to allow nutrient, waste and gas exchange. Consequently,
poor placentation leads to a reduction in maternal–fetal transfer, particularly of oxygen (O2), impeding fetal growth and development.

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