Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

Carl A. Anderson; Gabrielle Boucher; Charlie W. Lees; Andre Franke; Mauro D&apos;Amato; Kent D. Taylor; James C. Lee; Philippe Goyette; Marcin Imielinski; Anna Latiano; Caroline Lagace; Regan Scott; Leila Amininejad; Suzannah Bumpstead; Leonard Baidoo; Robert N. Baldassano; Murray Barclay; Theodore M. Bayless; Stephan Brand; Carsten Buening; Jean-Frederic Colombel; Lee A. Denson; Martine De Vos; Marla Dubinsky; Cathryn Edwards; David Ellinghaus; Rudolf S. N. Fehrmann; James A. B. Floyd; Timothy Florin; Denis Franchimont; Lude Franke; Michel Georges; Juergen Glas; Nicole L. Glazer; Stephen L. Guthery; Talin Haritunians; Nicholas K. Hayward; Jean-Pierre Hugot; Gilles Jobin; Debby Laukens; Ian Lawrance; Marc Lemann; Arie Levine; Cecile Libioulle; Edouard Louis; Dermot P. McGovern; Monica Milla; Grant W. Montgomery; Katherine Morley; Craig Mowat; Aylwin Ng; William Newman; Roel A. Ophoff; Laura Papi; Orazio Palmieri; Laurent Peyrin-Biroulet; Julian Panes; Anne Phillips; Natalie J. Prescott; Deborah D. Proctor; Rebecca Roberts; Richard Russell; Paul Rutgeerts; Jeremy Sanderson; Miquel Sans; Philip Schumm; Frank Seibold; Yashoda Sharma; Lisa A. Simms; Mark Seielstad; A. Hillary Steinhart; Stephan R. Targan; Leonard H. van den Berg; Morten Vatn; Hein Verspaget; Thomas Walters; Cisca Wijmenga; David C. Wilson; Harm-Jan Westra; Ramnik J. Xavier; Zhen Z. Zhao; Cyriel Y. Ponsioen; Vibeke Andersen; Leif Torkvist; Maria Gazouli; Nicholas P. Anagnou; Tom H. Karlsen; Limas Kupcinskas; Jurgita Sventoraityte; John C. Mansfield; Subra Kugathasan; Mark S. Silverberg; Jonas Halfvarson; Jerome I. Rotter; Christopher G. Mathew; Anne M. Griffiths; Richard Gearry; Tariq Ahmad; Steven R. Brant; Mathias Chamaillard; Jack Satsangi; Judy H. Cho; Stefan Schreiber; Mark J. Daly; Jeffrey C. Barrett; Miles Parkes; Vito Annese; Hakon Hakonarson; Graham Radford-Smith; Richard H. Duerr; Severine Vermeire; Rinse K. Weersma; John D. Rioux

doi:10.1038/ng.764

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

Carl A. Anderson, Gabrielle Boucher, Charlie W. Lees, Andre Franke, Mauro D'Amato, Kent D. Taylor, James C. Lee, Philippe Goyette, Marcin Imielinski, Anna Latiano, Caroline Lagace, Regan Scott, Leila Amininejad, Suzannah Bumpstead, Leonard Baidoo, Robert N. Baldassano, Murray Barclay, Theodore M. Bayless, Stephan Brand, Carsten BueningJean-Frederic Colombel, Lee A. Denson, Martine De Vos, Marla Dubinsky, Cathryn Edwards, David Ellinghaus, Rudolf S. N. Fehrmann, James A. B. Floyd, Timothy Florin, Denis Franchimont, Lude Franke, Michel Georges, Juergen Glas, Nicole L. Glazer, Stephen L. Guthery, Talin Haritunians, Nicholas K. Hayward, Jean-Pierre Hugot, Gilles Jobin, Debby Laukens, Ian Lawrance, Marc Lemann, Arie Levine, Cecile Libioulle, Edouard Louis, Dermot P. McGovern, Monica Milla, Grant W. Montgomery, Katherine Morley, Craig Mowat, Aylwin Ng, William Newman, Roel A. Ophoff, Laura Papi, Orazio Palmieri, Laurent Peyrin-Biroulet, Julian Panes, Anne Phillips, Natalie J. Prescott, Deborah D. Proctor, Rebecca Roberts, Richard Russell, Paul Rutgeerts, Jeremy Sanderson, Miquel Sans, Philip Schumm, Frank Seibold, Yashoda Sharma, Lisa A. Simms, Mark Seielstad, A. Hillary Steinhart, Stephan R. Targan, Leonard H. van den Berg, Morten Vatn, Hein Verspaget, Thomas Walters, Cisca Wijmenga, David C. Wilson, Harm-Jan Westra, Ramnik J. Xavier, Zhen Z. Zhao, Cyriel Y. Ponsioen, Vibeke Andersen, Leif Torkvist, Maria Gazouli, Nicholas P. Anagnou, Tom H. Karlsen, Limas Kupcinskas, Jurgita Sventoraityte, John C. Mansfield, Subra Kugathasan, Mark S. Silverberg, Jonas Halfvarson, Jerome I. Rotter, Christopher G. Mathew, Anne M. Griffiths, Richard Gearry, Tariq Ahmad, Steven R. Brant, Mathias Chamaillard, Jack Satsangi, Judy H. Cho, Stefan Schreiber, Mark J. Daly, Jeffrey C. Barrett, Miles Parkes, Vito Annese, Hakon Hakonarson, Graham Radford-Smith, Richard H. Duerr, Severine Vermeire, Rinse K. Weersma, John D. Rioux

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Abstract

Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P <5 x 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.

Original language	English
Pages (from-to)	246 - U94
Number of pages	7
Journal	Nature Genetics
Volume	43
Issue number	3
DOIs	https://doi.org/10.1038/ng.764
Publication status	Published - Mar 2011

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Anderson, C. A., Boucher, G., Lees, C. W., Franke, A., D'Amato, M., Taylor, K. D., Lee, J. C., Goyette, P., Imielinski, M., Latiano, A., Lagace, C., Scott, R., Amininejad, L., Bumpstead, S., Baidoo, L., Baldassano, R. N., Barclay, M., Bayless, T. M., Brand, S., ... Rioux, J. D. (2011). Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nature Genetics, 43(3), 246 - U94. https://doi.org/10.1038/ng.764

@article{9d589044be9043b2a98556ae2b4136de,

title = "Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47",

abstract = "Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P <5 x 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.",

author = "Anderson, {Carl A.} and Gabrielle Boucher and Lees, {Charlie W.} and Andre Franke and Mauro D'Amato and Taylor, {Kent D.} and Lee, {James C.} and Philippe Goyette and Marcin Imielinski and Anna Latiano and Caroline Lagace and Regan Scott and Leila Amininejad and Suzannah Bumpstead and Leonard Baidoo and Baldassano, {Robert N.} and Murray Barclay and Bayless, {Theodore M.} and Stephan Brand and Carsten Buening and Jean-Frederic Colombel and Denson, {Lee A.} and {De Vos}, Martine and Marla Dubinsky and Cathryn Edwards and David Ellinghaus and Fehrmann, {Rudolf S. N.} and Floyd, {James A. B.} and Timothy Florin and Denis Franchimont and Lude Franke and Michel Georges and Juergen Glas and Glazer, {Nicole L.} and Guthery, {Stephen L.} and Talin Haritunians and Hayward, {Nicholas K.} and Jean-Pierre Hugot and Gilles Jobin and Debby Laukens and Ian Lawrance and Marc Lemann and Arie Levine and Cecile Libioulle and Edouard Louis and McGovern, {Dermot P.} and Monica Milla and Montgomery, {Grant W.} and Katherine Morley and Craig Mowat and Aylwin Ng and William Newman and Ophoff, {Roel A.} and Laura Papi and Orazio Palmieri and Laurent Peyrin-Biroulet and Julian Panes and Anne Phillips and Prescott, {Natalie J.} and Proctor, {Deborah D.} and Rebecca Roberts and Richard Russell and Paul Rutgeerts and Jeremy Sanderson and Miquel Sans and Philip Schumm and Frank Seibold and Yashoda Sharma and Simms, {Lisa A.} and Mark Seielstad and Steinhart, {A. Hillary} and Targan, {Stephan R.} and {van den Berg}, {Leonard H.} and Morten Vatn and Hein Verspaget and Thomas Walters and Cisca Wijmenga and Wilson, {David C.} and Harm-Jan Westra and Xavier, {Ramnik J.} and Zhao, {Zhen Z.} and Ponsioen, {Cyriel Y.} and Vibeke Andersen and Leif Torkvist and Maria Gazouli and Anagnou, {Nicholas P.} and Karlsen, {Tom H.} and Limas Kupcinskas and Jurgita Sventoraityte and Mansfield, {John C.} and Subra Kugathasan and Silverberg, {Mark S.} and Jonas Halfvarson and Rotter, {Jerome I.} and Mathew, {Christopher G.} and Griffiths, {Anne M.} and Richard Gearry and Tariq Ahmad and Brant, {Steven R.} and Mathias Chamaillard and Jack Satsangi and Cho, {Judy H.} and Stefan Schreiber and Daly, {Mark J.} and Barrett, {Jeffrey C.} and Miles Parkes and Vito Annese and Hakon Hakonarson and Graham Radford-Smith and Duerr, {Richard H.} and Severine Vermeire and Weersma, {Rinse K.} and Rioux, {John D.}",

year = "2011",

month = mar,

doi = "10.1038/ng.764",

language = "English",

volume = "43",

pages = "246 -- U94",

journal = "Nature Genetics",

issn = "1546-1718",

publisher = "Nature Research",

number = "3",

}

Anderson, CA, Boucher, G, Lees, CW, Franke, A, D'Amato, M, Taylor, KD, Lee, JC, Goyette, P, Imielinski, M, Latiano, A, Lagace, C, Scott, R, Amininejad, L, Bumpstead, S, Baidoo, L, Baldassano, RN, Barclay, M, Bayless, TM, Brand, S, Buening, C, Colombel, J-F, Denson, LA, De Vos, M, Dubinsky, M, Edwards, C, Ellinghaus, D, Fehrmann, RSN, Floyd, JAB, Florin, T, Franchimont, D, Franke, L, Georges, M, Glas, J, Glazer, NL, Guthery, SL, Haritunians, T, Hayward, NK, Hugot, J-P, Jobin, G, Laukens, D, Lawrance, I, Lemann, M, Levine, A, Libioulle, C, Louis, E, McGovern, DP, Milla, M, Montgomery, GW, Morley, K, Mowat, C, Ng, A, Newman, W, Ophoff, RA, Papi, L, Palmieri, O, Peyrin-Biroulet, L, Panes, J, Phillips, A, Prescott, NJ, Proctor, DD, Roberts, R, Russell, R, Rutgeerts, P, Sanderson, J, Sans, M, Schumm, P, Seibold, F, Sharma, Y, Simms, LA, Seielstad, M, Steinhart, AH, Targan, SR, van den Berg, LH, Vatn, M, Verspaget, H, Walters, T, Wijmenga, C, Wilson, DC, Westra, H-J, Xavier, RJ, Zhao, ZZ, Ponsioen, CY, Andersen, V, Torkvist, L, Gazouli, M, Anagnou, NP, Karlsen, TH, Kupcinskas, L, Sventoraityte, J, Mansfield, JC, Kugathasan, S, Silverberg, MS, Halfvarson, J, Rotter, JI, Mathew, CG, Griffiths, AM, Gearry, R, Ahmad, T, Brant, SR, Chamaillard, M, Satsangi, J, Cho, JH, Schreiber, S, Daly, MJ, Barrett, JC, Parkes, M, Annese, V, Hakonarson, H, Radford-Smith, G, Duerr, RH, Vermeire, S, Weersma, RK & Rioux, JD 2011, 'Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47', Nature Genetics, vol. 43, no. 3, pp. 246 - U94. https://doi.org/10.1038/ng.764

TY - JOUR

T1 - Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

AU - Anderson, Carl A.

AU - Boucher, Gabrielle

AU - Lees, Charlie W.

AU - Franke, Andre

AU - D'Amato, Mauro

AU - Taylor, Kent D.

AU - Lee, James C.

AU - Goyette, Philippe

AU - Imielinski, Marcin

AU - Latiano, Anna

AU - Lagace, Caroline

AU - Scott, Regan

AU - Amininejad, Leila

AU - Bumpstead, Suzannah

AU - Baidoo, Leonard

AU - Baldassano, Robert N.

AU - Barclay, Murray

AU - Bayless, Theodore M.

AU - Brand, Stephan

AU - Buening, Carsten

AU - Colombel, Jean-Frederic

AU - Denson, Lee A.

AU - De Vos, Martine

AU - Dubinsky, Marla

AU - Edwards, Cathryn

AU - Ellinghaus, David

AU - Fehrmann, Rudolf S. N.

AU - Floyd, James A. B.

AU - Florin, Timothy

AU - Franchimont, Denis

AU - Franke, Lude

AU - Georges, Michel

AU - Glas, Juergen

AU - Glazer, Nicole L.

AU - Guthery, Stephen L.

AU - Haritunians, Talin

AU - Hayward, Nicholas K.

AU - Hugot, Jean-Pierre

AU - Jobin, Gilles

AU - Laukens, Debby

AU - Lawrance, Ian

AU - Lemann, Marc

AU - Levine, Arie

AU - Libioulle, Cecile

AU - Louis, Edouard

AU - McGovern, Dermot P.

AU - Milla, Monica

AU - Montgomery, Grant W.

AU - Morley, Katherine

AU - Mowat, Craig

AU - Ng, Aylwin

AU - Newman, William

AU - Ophoff, Roel A.

AU - Papi, Laura

AU - Palmieri, Orazio

AU - Peyrin-Biroulet, Laurent

AU - Panes, Julian

AU - Phillips, Anne

AU - Prescott, Natalie J.

AU - Proctor, Deborah D.

AU - Roberts, Rebecca

AU - Russell, Richard

AU - Rutgeerts, Paul

AU - Sanderson, Jeremy

AU - Sans, Miquel

AU - Schumm, Philip

AU - Seibold, Frank

AU - Sharma, Yashoda

AU - Simms, Lisa A.

AU - Seielstad, Mark

AU - Steinhart, A. Hillary

AU - Targan, Stephan R.

AU - van den Berg, Leonard H.

AU - Vatn, Morten

AU - Verspaget, Hein

AU - Walters, Thomas

AU - Wijmenga, Cisca

AU - Wilson, David C.

AU - Westra, Harm-Jan

AU - Xavier, Ramnik J.

AU - Zhao, Zhen Z.

AU - Ponsioen, Cyriel Y.

AU - Andersen, Vibeke

AU - Torkvist, Leif

AU - Gazouli, Maria

AU - Anagnou, Nicholas P.

AU - Karlsen, Tom H.

AU - Kupcinskas, Limas

AU - Sventoraityte, Jurgita

AU - Mansfield, John C.

AU - Kugathasan, Subra

AU - Silverberg, Mark S.

AU - Halfvarson, Jonas

AU - Rotter, Jerome I.

AU - Mathew, Christopher G.

AU - Griffiths, Anne M.

AU - Gearry, Richard

AU - Ahmad, Tariq

AU - Brant, Steven R.

AU - Chamaillard, Mathias

AU - Satsangi, Jack

AU - Cho, Judy H.

AU - Schreiber, Stefan

AU - Daly, Mark J.

AU - Barrett, Jeffrey C.

AU - Parkes, Miles

AU - Annese, Vito

AU - Hakonarson, Hakon

AU - Radford-Smith, Graham

AU - Duerr, Richard H.

AU - Vermeire, Severine

AU - Weersma, Rinse K.

AU - Rioux, John D.

PY - 2011/3

Y1 - 2011/3

N2 - Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P <5 x 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.

AB - Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P <5 x 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.

U2 - 10.1038/ng.764

DO - 10.1038/ng.764

M3 - Article

SN - 1546-1718

VL - 43

SP - 246 - U94

JO - Nature Genetics

JF - Nature Genetics

IS - 3

ER -

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

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