Meta-Analysis of Genome-Wide Linkage Scans of Attention Deficit Hyperactivity Disorder

Kaixin Zhou; Astrid Dempfle; Mauricio Arcos-Burgos; Steven C. Bakker; Tobias Banaschewski; Joseph Biederman; Jan Buitelaar; F. Xavier Castellanos; Alysa Doyle; Richard P. Ebstein; Jenny Ekholm; Paola Forabosco; Barbara Franke; Christine Freitag; Susann Friedel; Michael Gill; Johannes Hebebrand; Anke Hinney; Christian Jacob; Klaus Peter Lesch; Sandra K. Loo; Francisco Lopera; James T. McCracken; James J. McGough; Jobst Meyer; Eric Mick; Ana Miranda; Maximilian Muenkel; Fernando Mulas; Stanley F. Nelson; T. Trang Nguyen; Robert D. Oades; Matthew N. Ogdie; Juan David Palacio; David Pineda; Andreas Reif; Tobias J. Renner; Herbert Roeyers; Marcel Romanos; Aribert Rothenberger; Helmut Schaefer; Joseph Sergeant; Richard J. Sinke; Susan L. Smalley; Edmund Sonuga-Barke; Hans-Christoph Steinhausen; Emma van der Meulen; Susanne Walitza; Andreas Warnke; Cathryn M. Lewis; Stephen V. Faraone; Philip Asherson

doi:10.1002/ajmg.b.30878

Meta-Analysis of Genome-Wide Linkage Scans of Attention Deficit Hyperactivity Disorder

Kaixin Zhou, Astrid Dempfle, Mauricio Arcos-Burgos, Steven C. Bakker, Tobias Banaschewski, Joseph Biederman, Jan Buitelaar, F. Xavier Castellanos, Alysa Doyle, Richard P. Ebstein, Jenny Ekholm, Paola Forabosco, Barbara Franke, Christine Freitag, Susann Friedel, Michael Gill, Johannes Hebebrand, Anke Hinney, Christian Jacob, Klaus Peter LeschSandra K. Loo, Francisco Lopera, James T. McCracken, James J. McGough, Jobst Meyer, Eric Mick, Ana Miranda, Maximilian Muenkel, Fernando Mulas, Stanley F. Nelson, T. Trang Nguyen, Robert D. Oades, Matthew N. Ogdie, Juan David Palacio, David Pineda, Andreas Reif, Tobias J. Renner, Herbert Roeyers, Marcel Romanos, Aribert Rothenberger, Helmut Schaefer, Joseph Sergeant, Richard J. Sinke, Susan L. Smalley, Edmund Sonuga-Barke, Hans-Christoph Steinhausen, Emma van der Meulen, Susanne Walitza, Andreas Warnke, Cathryn M. Lewis, Stephen V. Faraone, Philip Asherson

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Abstract

Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome-wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome-wide significant linkage (P-SR = 0.00034, P-OR = 0.04) was identified on chromosome 16 between 64 and 83 Nth. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes. (c) 2008 Wiley-Liss, Inc.

Original language	English
Pages (from-to)	1392 - 1398
Number of pages	7
Journal	American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
Volume	147B
Issue number	8
DOIs	https://doi.org/10.1002/ajmg.b.30878
Publication status	Published - 5 Dec 2008

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Zhou, K., Dempfle, A., Arcos-Burgos, M., Bakker, S. C., Banaschewski, T., Biederman, J., Buitelaar, J., Castellanos, F. X., Doyle, A., Ebstein, R. P., Ekholm, J., Forabosco, P., Franke, B., Freitag, C., Friedel, S., Gill, M., Hebebrand, J., Hinney, A., Jacob, C., ... Asherson, P. (2008). Meta-Analysis of Genome-Wide Linkage Scans of Attention Deficit Hyperactivity Disorder. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 147B(8), 1392 - 1398. https://doi.org/10.1002/ajmg.b.30878

@article{d8e031c67a5a404aad88f07672451fda,

title = "Meta-Analysis of Genome-Wide Linkage Scans of Attention Deficit Hyperactivity Disorder",

abstract = "Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome-wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome-wide significant linkage (P-SR = 0.00034, P-OR = 0.04) was identified on chromosome 16 between 64 and 83 Nth. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes. (c) 2008 Wiley-Liss, Inc.",

author = "Kaixin Zhou and Astrid Dempfle and Mauricio Arcos-Burgos and Bakker, {Steven C.} and Tobias Banaschewski and Joseph Biederman and Jan Buitelaar and Castellanos, {F. Xavier} and Alysa Doyle and Ebstein, {Richard P.} and Jenny Ekholm and Paola Forabosco and Barbara Franke and Christine Freitag and Susann Friedel and Michael Gill and Johannes Hebebrand and Anke Hinney and Christian Jacob and Lesch, {Klaus Peter} and Loo, {Sandra K.} and Francisco Lopera and McCracken, {James T.} and McGough, {James J.} and Jobst Meyer and Eric Mick and Ana Miranda and Maximilian Muenkel and Fernando Mulas and Nelson, {Stanley F.} and Nguyen, {T. Trang} and Oades, {Robert D.} and Ogdie, {Matthew N.} and Palacio, {Juan David} and David Pineda and Andreas Reif and Renner, {Tobias J.} and Herbert Roeyers and Marcel Romanos and Aribert Rothenberger and Helmut Schaefer and Joseph Sergeant and Sinke, {Richard J.} and Smalley, {Susan L.} and Edmund Sonuga-Barke and Hans-Christoph Steinhausen and {van der Meulen}, Emma and Susanne Walitza and Andreas Warnke and Lewis, {Cathryn M.} and Faraone, {Stephen V.} and Philip Asherson",

year = "2008",

month = dec,

day = "5",

doi = "10.1002/ajmg.b.30878",

language = "English",

volume = "147B",

pages = "1392 -- 1398",

journal = "American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics",

issn = "1552-485X",

publisher = "Wiley-Liss Inc.",

number = "8",

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Zhou, K, Dempfle, A, Arcos-Burgos, M, Bakker, SC, Banaschewski, T, Biederman, J, Buitelaar, J, Castellanos, FX, Doyle, A, Ebstein, RP, Ekholm, J, Forabosco, P, Franke, B, Freitag, C, Friedel, S, Gill, M, Hebebrand, J, Hinney, A, Jacob, C, Lesch, KP, Loo, SK, Lopera, F, McCracken, JT, McGough, JJ, Meyer, J, Mick, E, Miranda, A, Muenkel, M, Mulas, F, Nelson, SF, Nguyen, TT, Oades, RD, Ogdie, MN, Palacio, JD, Pineda, D, Reif, A, Renner, TJ, Roeyers, H, Romanos, M, Rothenberger, A, Schaefer, H, Sergeant, J, Sinke, RJ, Smalley, SL, Sonuga-Barke, E, Steinhausen, H-C, van der Meulen, E, Walitza, S, Warnke, A, Lewis, CM, Faraone, SV & Asherson, P 2008, 'Meta-Analysis of Genome-Wide Linkage Scans of Attention Deficit Hyperactivity Disorder', American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, vol. 147B, no. 8, pp. 1392 - 1398. https://doi.org/10.1002/ajmg.b.30878

TY - JOUR

T1 - Meta-Analysis of Genome-Wide Linkage Scans of Attention Deficit Hyperactivity Disorder

AU - Zhou, Kaixin

AU - Dempfle, Astrid

AU - Arcos-Burgos, Mauricio

AU - Bakker, Steven C.

AU - Banaschewski, Tobias

AU - Biederman, Joseph

AU - Buitelaar, Jan

AU - Castellanos, F. Xavier

AU - Doyle, Alysa

AU - Ebstein, Richard P.

AU - Ekholm, Jenny

AU - Forabosco, Paola

AU - Franke, Barbara

AU - Freitag, Christine

AU - Friedel, Susann

AU - Gill, Michael

AU - Hebebrand, Johannes

AU - Hinney, Anke

AU - Jacob, Christian

AU - Lesch, Klaus Peter

AU - Loo, Sandra K.

AU - Lopera, Francisco

AU - McCracken, James T.

AU - McGough, James J.

AU - Meyer, Jobst

AU - Mick, Eric

AU - Miranda, Ana

AU - Muenkel, Maximilian

AU - Mulas, Fernando

AU - Nelson, Stanley F.

AU - Nguyen, T. Trang

AU - Oades, Robert D.

AU - Ogdie, Matthew N.

AU - Palacio, Juan David

AU - Pineda, David

AU - Reif, Andreas

AU - Renner, Tobias J.

AU - Roeyers, Herbert

AU - Romanos, Marcel

AU - Rothenberger, Aribert

AU - Schaefer, Helmut

AU - Sergeant, Joseph

AU - Sinke, Richard J.

AU - Smalley, Susan L.

AU - Sonuga-Barke, Edmund

AU - Steinhausen, Hans-Christoph

AU - van der Meulen, Emma

AU - Walitza, Susanne

AU - Warnke, Andreas

AU - Lewis, Cathryn M.

AU - Faraone, Stephen V.

AU - Asherson, Philip

PY - 2008/12/5

Y1 - 2008/12/5

N2 - Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome-wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome-wide significant linkage (P-SR = 0.00034, P-OR = 0.04) was identified on chromosome 16 between 64 and 83 Nth. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes. (c) 2008 Wiley-Liss, Inc.

AB - Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome-wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome-wide significant linkage (P-SR = 0.00034, P-OR = 0.04) was identified on chromosome 16 between 64 and 83 Nth. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes. (c) 2008 Wiley-Liss, Inc.

U2 - 10.1002/ajmg.b.30878

DO - 10.1002/ajmg.b.30878

M3 - Article

SN - 1552-485X

VL - 147B

SP - 1392

EP - 1398

JO - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

IS - 8

ER -

Meta-Analysis of Genome-Wide Linkage Scans of Attention Deficit Hyperactivity Disorder

Abstract

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