Meta-analysis of response inhibition in juvenile myoclonic epilepsy

TY - JOUR

T1 - Meta-analysis of response inhibition in juvenile myoclonic epilepsy

AU - Smith, Anna

AU - Syvertsen, Marte

AU - Pal, Deb K.

PY - 2020/5

Y1 - 2020/5

N2 - Background: Patients with juvenile myoclonic epilepsy (JME) show evidence of cognitive impulsivity that may be linked to later adverse psychosocial outcomes. Here, we quantify the strength of association and estimate effect size (ES) of response inhibition by pooling available evidence in a meta-analysis. Methods: We conducted a systematic review of the literature using Ovid MEDLINE and Ovid EMBASE databases (covering 2001–2019) with a search strategy using combinations of the specific Medical Subject Headings (MeSH) terms ‘juvenile myoclonic epilepsy, cognitive impulsivity, response inhibition, Stroop, cognition, personality, traits’ using the ‘explode’ feature where possible. We also searched within references of retrieved articles. We included studies reporting ESs describing established measures of response inhibition in teenage and adult patients with JME. Results: Using the ESs pooled from 16 studies comprising 1047 patients and controls, we found ESs for response inhibition to be homogeneous with a significant moderate mean ES of d = 0.50 (95% confidence interval [CI]: 0.37–0.63). Conclusions: We confirm that reduced response inhibition is a consistently observed homogeneous trait in patients with JME.

AB - Background: Patients with juvenile myoclonic epilepsy (JME) show evidence of cognitive impulsivity that may be linked to later adverse psychosocial outcomes. Here, we quantify the strength of association and estimate effect size (ES) of response inhibition by pooling available evidence in a meta-analysis. Methods: We conducted a systematic review of the literature using Ovid MEDLINE and Ovid EMBASE databases (covering 2001–2019) with a search strategy using combinations of the specific Medical Subject Headings (MeSH) terms ‘juvenile myoclonic epilepsy, cognitive impulsivity, response inhibition, Stroop, cognition, personality, traits’ using the ‘explode’ feature where possible. We also searched within references of retrieved articles. We included studies reporting ESs describing established measures of response inhibition in teenage and adult patients with JME. Results: Using the ESs pooled from 16 studies comprising 1047 patients and controls, we found ESs for response inhibition to be homogeneous with a significant moderate mean ES of d = 0.50 (95% confidence interval [CI]: 0.37–0.63). Conclusions: We confirm that reduced response inhibition is a consistently observed homogeneous trait in patients with JME.

KW - Executive function

KW - Impulsivity

KW - JME

KW - Psychosocial

KW - Stroop task

UR - http://www.scopus.com/inward/record.url?scp=85082414498&partnerID=8YFLogxK

U2 - 10.1016/j.yebeh.2020.107038

DO - 10.1016/j.yebeh.2020.107038

M3 - Review article

AN - SCOPUS:85082414498

SN - 1525-5050

VL - 106

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

M1 - 107038

ER -