Meta-analysis of the effects of foods and derived products containing ellagitannins and anthocyanins on cardiometabolic biomarkers: Analysis of factors influencing variability of the individual responses

María Teresa García-Conesa, Karen Chambers, Emilie Combet, Paula Pinto, Mar Garcia-Aloy, Cristina Andrés-Lacueva, Sonia De Pascual-Teresa, Pedro Mena, Alekxandra Konic Ristic, Wendy J. Hollands, Paul A. Kroon, Ana Rodríguez-Mateos, Geoffrey Istas, Christos A. Kontogiorgis, Dilip K. Rai, Eileen R. Gibney, Christine Morand, Juan Carlos Espín, Antonio González-Sarrías*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

100 Citations (Scopus)


Understanding interindividual variability in response to dietary polyphenols remains essential to elucidate their effects on cardiometabolic disease development. A meta-analysis of 128 randomized clinical trials was conducted to investigate the effects of berries and red grapes/wine as sources of anthocyanins and of nuts and pomegranate as sources of ellagitannins on a range of cardiometabolic risk biomarkers. The potential influence of various demographic and lifestyle factors on the variability in the response to these products were explored. Both anthocyanin- and ellagitannin-containing products reduced total-cholesterol with nuts and berries yielding more significant effects than pomegranate and grapes. Blood pressure was significantly reduced by the two main sources of anthocyanins, berries and red grapes/wine, whereas waist circumference, LDL-cholesterol, triglycerides, and glucose were most significantly lowered by the ellagitannin-products, particularly nuts. Additionally, we found an indication of a small increase in HDL-cholesterol most significant with nuts and, in flow-mediated dilation by nuts and berries. Most of these effects were detected in obese/overweight people but we found limited or non-evidence in normoweight individuals or of the influence of sex or smoking status. The effects of other factors, i.e., habitual diet, health status or country where the study was conducted, were inconsistent and require further investigation.

Original languageEnglish
Article number694
JournalInternational Journal of Molecular Sciences
Issue number3
Early online date28 Feb 2018
Publication statusPublished - Mar 2018


  • Anthocyanins
  • Berries
  • Cardiometabolic disorders
  • Ellagitannins
  • Interindividual variability
  • Meta-analysis
  • Nuts
  • Pomegranate
  • Red grapes
  • Red wine

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