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Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia

Research output: Contribution to journalArticle

The Consortium for Refractive Error and Myopia, The UK Eye and Vision Consortium, 23andMe Inc.

Original languageEnglish
Pages (from-to)401-407
Number of pages7
JournalNature Genetics
Volume52
Issue number4
Early online date30 Mar 2020
DOIs
Publication statusPublished - Apr 2020

King's Authors

  • The Consortium for Refractive Error and Myopia
  • The UK Eye and Vision Consortium
  • 23andMe Inc.

Abstract

Refractive errors, in particular myopia, are a leading cause of morbidity and disability worldwide. Genetic investigation can improve understanding of the molecular mechanisms that underlie abnormal eye development and impaired vision. We conducted a meta-analysis of genome-wide association studies (GWAS) that involved 542,934 European participants and identified 336 novel genetic loci associated with refractive error. Collectively, all associated genetic variants explain 18.4% of heritability and improve the accuracy of myopia prediction (area under the curve (AUC) = 0.75). Our results suggest that refractive error is genetically heterogeneous, driven by genes that participate in the development of every anatomical component of the eye. In addition, our analyses suggest that genetic factors controlling circadian rhythm and pigmentation are also involved in the development of myopia and refractive error. These results may enable the prediction of refractive error and the development of personalized myopia prevention strategies in the future.

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