Metabolic characterization of the R6/2 transgenic mouse model of Huntington's disease by high-resolution MAS H-1 NMR spectroscopy

TY - JOUR

T1 - Metabolic characterization of the R6/2 transgenic mouse model of Huntington's disease by high-resolution MAS H-1 NMR spectroscopy

AU - Tsang, T A

AU - Woodman, B

AU - McLoughlin, G A

AU - Griffin, J L

AU - Tabrizi, S J

AU - Bates, G P

AU - Holmes, E

PY - 2006/3

Y1 - 2006/3

N2 - The metabolic consequences of Huntington's disease in the R6/2 mouse model were investigated using NMR spectroscopy and pattern recognition to characterize selected brain regions, muscle, blood, and urine. Global increases in relative brain concentrations of osmolytes, creatine, glutamine, and lactate, and decreases in acetate and N-acetylaspartate were found together with striatal-specific lower concentrations of GABA and choline. Clear differentiation of R6/2 and wild-type mice was also obtained for urine and blood metabolite profiles that may have applicability for monitoring HD in human populations

AB - The metabolic consequences of Huntington's disease in the R6/2 mouse model were investigated using NMR spectroscopy and pattern recognition to characterize selected brain regions, muscle, blood, and urine. Global increases in relative brain concentrations of osmolytes, creatine, glutamine, and lactate, and decreases in acetate and N-acetylaspartate were found together with striatal-specific lower concentrations of GABA and choline. Clear differentiation of R6/2 and wild-type mice was also obtained for urine and blood metabolite profiles that may have applicability for monitoring HD in human populations

U2 - 10.1021/pr050244o

DO - 10.1021/pr050244o

M3 - Article

VL - 5

SP - 483

EP - 492

JO - JOURNAL OF PROTEOME RESEARCH

JF - JOURNAL OF PROTEOME RESEARCH

IS - 3

ER -