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Metabolic patterns across core features in dementia with lewy bodies

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Metabolic patterns across core features in dementia with lewy bodies. / Morbelli, Silvia; Chincarini, Andrea; Brendel, Matthias; Rominger, Axel; Bruffaerts, Rose; Vandenberghe, Rik; Kramberger, Milica G.; Trost, Maja; Garibotto, Valentina; Nicastro, Nicolas; Frisoni, Giovanni B.; Lemstra, Afina W.; van der Zande, Jessica; Pilotto, Andrea; Padovani, Alessandro; Garcia-Ptacek, Sara; Savitcheva, Irina; Ochoa-Figueroa, Miguel A.; Davidsson, Annette; Camacho, Valle; Peira, Enrico; Arnaldi, Dario; Bauckneht, Matteo; Pardini, Matteo; Sambuceti, Gianmario; Aarsland, Dag; Nobili, Flavio.

In: Annals of Neurology, Vol. 85, No. 5, 01.05.2019, p. 715-725.

Research output: Contribution to journalArticle

Harvard

Morbelli, S, Chincarini, A, Brendel, M, Rominger, A, Bruffaerts, R, Vandenberghe, R, Kramberger, MG, Trost, M, Garibotto, V, Nicastro, N, Frisoni, GB, Lemstra, AW, van der Zande, J, Pilotto, A, Padovani, A, Garcia-Ptacek, S, Savitcheva, I, Ochoa-Figueroa, MA, Davidsson, A, Camacho, V, Peira, E, Arnaldi, D, Bauckneht, M, Pardini, M, Sambuceti, G, Aarsland, D & Nobili, F 2019, 'Metabolic patterns across core features in dementia with lewy bodies', Annals of Neurology, vol. 85, no. 5, pp. 715-725. https://doi.org/10.1002/ana.25453

APA

Morbelli, S., Chincarini, A., Brendel, M., Rominger, A., Bruffaerts, R., Vandenberghe, R., ... Nobili, F. (2019). Metabolic patterns across core features in dementia with lewy bodies. Annals of Neurology, 85(5), 715-725. https://doi.org/10.1002/ana.25453

Vancouver

Morbelli S, Chincarini A, Brendel M, Rominger A, Bruffaerts R, Vandenberghe R et al. Metabolic patterns across core features in dementia with lewy bodies. Annals of Neurology. 2019 May 1;85(5):715-725. https://doi.org/10.1002/ana.25453

Author

Morbelli, Silvia ; Chincarini, Andrea ; Brendel, Matthias ; Rominger, Axel ; Bruffaerts, Rose ; Vandenberghe, Rik ; Kramberger, Milica G. ; Trost, Maja ; Garibotto, Valentina ; Nicastro, Nicolas ; Frisoni, Giovanni B. ; Lemstra, Afina W. ; van der Zande, Jessica ; Pilotto, Andrea ; Padovani, Alessandro ; Garcia-Ptacek, Sara ; Savitcheva, Irina ; Ochoa-Figueroa, Miguel A. ; Davidsson, Annette ; Camacho, Valle ; Peira, Enrico ; Arnaldi, Dario ; Bauckneht, Matteo ; Pardini, Matteo ; Sambuceti, Gianmario ; Aarsland, Dag ; Nobili, Flavio. / Metabolic patterns across core features in dementia with lewy bodies. In: Annals of Neurology. 2019 ; Vol. 85, No. 5. pp. 715-725.

Bibtex Download

@article{312d2d10240b4548b13bf449416b2111,
title = "Metabolic patterns across core features in dementia with lewy bodies",
abstract = "To identify brain regions whose metabolic impairment contributes to DLB clinical core features expression and to assess the influence of severity of global cognitive impairment on the DLB-hypometabolic-pattern. Brain FDG-PET and information on core features were available in 171 patients belonging to the imaging repository of the European DLB-consortium. Principal component analysis was applied to identify brain regions relevant to the local data variance. A linear regression model was applied to generate core feature-specific patterns controlling for the main confounding variables (MMSE, Age, Education, Gender, and Center). Regression analysis to the locally-normalized intensities was performed to generate a MMSE score-sensitive map. Parkinsonism negatively covaried with bilateral parietal, precuneus and anterior cingulate metabolism, visual-hallucinations with bilateral dorsolateral-frontal cortex, posterior cingulate and parietal metabolism and RBD with bilateral parieto-occipital cortex, precuneus and ventrolateral-frontal metabolism. VH and RBD shared a positive covariance with metabolism in medial temporal lobe, cerebellum, brainstem, basal ganglia, thalami, orbitofrontal and sensorimotor cortex. Cognitive fluctuations negatively covaried with occipital metabolism and positively with parietal lobes metabolism. MMSE positively covaried with metabolism in left superior frontal gyrus, bilateral-parietal cortex, and left precuneus, and negatively with metabolism in insula, medial frontal gyrus, hippocampus in the left hemisphere and in right cerebellum. Regions of more preserved metabolism are relatively consistent across the variegate DLB spectrum. By contrast, core features were associated to more prominent hypometabolism in specific regions thus suggesting a close clinical-imaging correlation, reflecting the interplay between topography of neurodegeneration and clinical presentation in DLB patients. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.",
author = "Silvia Morbelli and Andrea Chincarini and Matthias Brendel and Axel Rominger and Rose Bruffaerts and Rik Vandenberghe and Kramberger, {Milica G.} and Maja Trost and Valentina Garibotto and Nicolas Nicastro and Frisoni, {Giovanni B.} and Lemstra, {Afina W.} and {van der Zande}, Jessica and Andrea Pilotto and Alessandro Padovani and Sara Garcia-Ptacek and Irina Savitcheva and Ochoa-Figueroa, {Miguel A.} and Annette Davidsson and Valle Camacho and Enrico Peira and Dario Arnaldi and Matteo Bauckneht and Matteo Pardini and Gianmario Sambuceti and Dag Aarsland and Flavio Nobili",
year = "2019",
month = "5",
day = "1",
doi = "10.1002/ana.25453",
language = "English",
volume = "85",
pages = "715--725",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Metabolic patterns across core features in dementia with lewy bodies

AU - Morbelli, Silvia

AU - Chincarini, Andrea

AU - Brendel, Matthias

AU - Rominger, Axel

AU - Bruffaerts, Rose

AU - Vandenberghe, Rik

AU - Kramberger, Milica G.

AU - Trost, Maja

AU - Garibotto, Valentina

AU - Nicastro, Nicolas

AU - Frisoni, Giovanni B.

AU - Lemstra, Afina W.

AU - van der Zande, Jessica

AU - Pilotto, Andrea

AU - Padovani, Alessandro

AU - Garcia-Ptacek, Sara

AU - Savitcheva, Irina

AU - Ochoa-Figueroa, Miguel A.

AU - Davidsson, Annette

AU - Camacho, Valle

AU - Peira, Enrico

AU - Arnaldi, Dario

AU - Bauckneht, Matteo

AU - Pardini, Matteo

AU - Sambuceti, Gianmario

AU - Aarsland, Dag

AU - Nobili, Flavio

PY - 2019/5/1

Y1 - 2019/5/1

N2 - To identify brain regions whose metabolic impairment contributes to DLB clinical core features expression and to assess the influence of severity of global cognitive impairment on the DLB-hypometabolic-pattern. Brain FDG-PET and information on core features were available in 171 patients belonging to the imaging repository of the European DLB-consortium. Principal component analysis was applied to identify brain regions relevant to the local data variance. A linear regression model was applied to generate core feature-specific patterns controlling for the main confounding variables (MMSE, Age, Education, Gender, and Center). Regression analysis to the locally-normalized intensities was performed to generate a MMSE score-sensitive map. Parkinsonism negatively covaried with bilateral parietal, precuneus and anterior cingulate metabolism, visual-hallucinations with bilateral dorsolateral-frontal cortex, posterior cingulate and parietal metabolism and RBD with bilateral parieto-occipital cortex, precuneus and ventrolateral-frontal metabolism. VH and RBD shared a positive covariance with metabolism in medial temporal lobe, cerebellum, brainstem, basal ganglia, thalami, orbitofrontal and sensorimotor cortex. Cognitive fluctuations negatively covaried with occipital metabolism and positively with parietal lobes metabolism. MMSE positively covaried with metabolism in left superior frontal gyrus, bilateral-parietal cortex, and left precuneus, and negatively with metabolism in insula, medial frontal gyrus, hippocampus in the left hemisphere and in right cerebellum. Regions of more preserved metabolism are relatively consistent across the variegate DLB spectrum. By contrast, core features were associated to more prominent hypometabolism in specific regions thus suggesting a close clinical-imaging correlation, reflecting the interplay between topography of neurodegeneration and clinical presentation in DLB patients. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

AB - To identify brain regions whose metabolic impairment contributes to DLB clinical core features expression and to assess the influence of severity of global cognitive impairment on the DLB-hypometabolic-pattern. Brain FDG-PET and information on core features were available in 171 patients belonging to the imaging repository of the European DLB-consortium. Principal component analysis was applied to identify brain regions relevant to the local data variance. A linear regression model was applied to generate core feature-specific patterns controlling for the main confounding variables (MMSE, Age, Education, Gender, and Center). Regression analysis to the locally-normalized intensities was performed to generate a MMSE score-sensitive map. Parkinsonism negatively covaried with bilateral parietal, precuneus and anterior cingulate metabolism, visual-hallucinations with bilateral dorsolateral-frontal cortex, posterior cingulate and parietal metabolism and RBD with bilateral parieto-occipital cortex, precuneus and ventrolateral-frontal metabolism. VH and RBD shared a positive covariance with metabolism in medial temporal lobe, cerebellum, brainstem, basal ganglia, thalami, orbitofrontal and sensorimotor cortex. Cognitive fluctuations negatively covaried with occipital metabolism and positively with parietal lobes metabolism. MMSE positively covaried with metabolism in left superior frontal gyrus, bilateral-parietal cortex, and left precuneus, and negatively with metabolism in insula, medial frontal gyrus, hippocampus in the left hemisphere and in right cerebellum. Regions of more preserved metabolism are relatively consistent across the variegate DLB spectrum. By contrast, core features were associated to more prominent hypometabolism in specific regions thus suggesting a close clinical-imaging correlation, reflecting the interplay between topography of neurodegeneration and clinical presentation in DLB patients. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

UR - http://www.scopus.com/inward/record.url?scp=85063268444&partnerID=8YFLogxK

U2 - 10.1002/ana.25453

DO - 10.1002/ana.25453

M3 - Article

AN - SCOPUS:85063268444

VL - 85

SP - 715

EP - 725

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 5

ER -

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