Metabolic syndrome and comorbidities in patients with psoriasis: a community-based case-control study from the Nagahama cohort in Japan

Yuichiro Endo; Yasuharu Tabara; Takahisa Kawaguchi; Alexandros Onoufriadis; John A. McGrath; Fumihiko Matsuda; Kenji Kabashima

doi:10.1684/ejd.2022.4231

Metabolic syndrome and comorbidities in patients with psoriasis: a community-based case-control study from the Nagahama cohort in Japan

Yuichiro Endo, Yasuharu Tabara, Takahisa Kawaguchi, Alexandros Onoufriadis, John A. McGrath, Fumihiko Matsuda, Kenji Kabashima

Dermatology

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Psoriasis is reported to be associated with systemic diseases, such as metabolic syndrome (MetS), which is related to high blood pressure, hyperglycaemia, obesity and dyslipidaemia. However, clinical factors associated with psoriasis in the general population have not been fully elucidated. Objectives: To explore the clinical factors associated with psoriasis by analysing a dataset of community-based cohort studies Materials & Methods: The study participants consisted of 9,183 apparently healthy community residents in Japan (mean age: 64.5 ± 10.7 years). The clinical parameters used in this study were obtained from a baseline investigation performed between 2008 and 2010. The history of psoriasis was queried using a structured questionnaire Results: A total of 335 participants (3.6%) had a history of psoriasis. The psoriasis group was older (64.5 ± 10.7 vs 57.9 ± 12.3 years; p < 0.001) and mostly male (43.9 vs 33.0 %, p < 0.001) compared to the non-psoriasis group. Based on univariate analysis, the prevalence of MetS was higher in the psoriasis group (19.1 vs 13.6%, odds ratio = 1.50, p = 0.004), although this association disappeared after adjustment for age and sex. Similar results were observed based on the analysis of each MetS component. Other factors associated with psoriasis were history of tinea pedis (age-and sex-adjusted odds ratio = 5.27), gout (1.97), chronic obstructive pulmonary disease (5.83), reflux oesophagitis (1.72) and depressive symptoms (1.57). After further adjustment for potential covariates, the associations with these factors remained significant. Conclusion: Several chronic conditions associated with psoriasis in the general population were identified.

Original language	English
Pages (from-to)	86-93
Number of pages	8
Journal	European journal of dermatology : EJD
Volume	32
Issue number	1
DOIs	https://doi.org/10.1684/ejd.2022.4231
Publication status	Published - Jan 2022

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@article{01adea7597294f9393de430cc2a4a662,

title = "Metabolic syndrome and comorbidities in patients with psoriasis: a community-based case-control study from the Nagahama cohort in Japan",

abstract = "Background: Psoriasis is reported to be associated with systemic diseases, such as metabolic syndrome (MetS), which is related to high blood pressure, hyperglycaemia, obesity and dyslipidaemia. However, clinical factors associated with psoriasis in the general population have not been fully elucidated. Objectives: To explore the clinical factors associated with psoriasis by analysing a dataset of community-based cohort studies Materials & Methods: The study participants consisted of 9,183 apparently healthy community residents in Japan (mean age: 64.5 ± 10.7 years). The clinical parameters used in this study were obtained from a baseline investigation performed between 2008 and 2010. The history of psoriasis was queried using a structured questionnaire Results: A total of 335 participants (3.6%) had a history of psoriasis. The psoriasis group was older (64.5 ± 10.7 vs 57.9 ± 12.3 years; p < 0.001) and mostly male (43.9 vs 33.0 %, p < 0.001) compared to the non-psoriasis group. Based on univariate analysis, the prevalence of MetS was higher in the psoriasis group (19.1 vs 13.6%, odds ratio = 1.50, p = 0.004), although this association disappeared after adjustment for age and sex. Similar results were observed based on the analysis of each MetS component. Other factors associated with psoriasis were history of tinea pedis (age-and sex-adjusted odds ratio = 5.27), gout (1.97), chronic obstructive pulmonary disease (5.83), reflux oesophagitis (1.72) and depressive symptoms (1.57). After further adjustment for potential covariates, the associations with these factors remained significant. Conclusion: Several chronic conditions associated with psoriasis in the general population were identified.",

author = "Yuichiro Endo and Yasuharu Tabara and Takahisa Kawaguchi and Alexandros Onoufriadis and McGrath, {John A.} and Fumihiko Matsuda and Kenji Kabashima",

note = "Funding Information: this study was supported by the following grants: University Grants and Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology in Japan; The Centre of Innovation Programme and the Global University Project from Japan Science and Technology Agency; and The Practical Research Project for Rare/Intractable Diseases and Comprehensive Research on Ageing and Health Science Research Grants for Dementia R&D from the Japan Agency for Medical Research and Development (AMED). Funding Information: the Nagahama Study Group Executive Committee is composed of the following individuals: Yasuharu Tabara, Takahisa Kawaguchi, Kazuya Setoh, Yoshimitsu Takahashi, Shinji Kosugi, Takeo Nakayama and Fumihiko Matsuda from the Centre for Genomic Medicine, Kyoto University Graduate School of Medicine (Ya.T, T.K., K.S., F.M.); Department of Health Informatics (Yo.T, T.N.); and the Department of Medical Ethics and Medical Genetics (S.K.), Kyoto University School of Public Health. Publisher Copyright: {\textcopyright} 2022, JLE/Springer.",

year = "2022",

month = jan,

doi = "10.1684/ejd.2022.4231",

language = "English",

volume = "32",

pages = "86--93",

journal = "European journal of dermatology : EJD",

issn = "1952-4013",

publisher = "John Libbey Eurotext",

number = "1",

}

TY - JOUR

T1 - Metabolic syndrome and comorbidities in patients with psoriasis

T2 - a community-based case-control study from the Nagahama cohort in Japan

AU - Endo, Yuichiro

AU - Tabara, Yasuharu

AU - Kawaguchi, Takahisa

AU - Onoufriadis, Alexandros

AU - McGrath, John A.

AU - Matsuda, Fumihiko

AU - Kabashima, Kenji

N1 - Funding Information: this study was supported by the following grants: University Grants and Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology in Japan; The Centre of Innovation Programme and the Global University Project from Japan Science and Technology Agency; and The Practical Research Project for Rare/Intractable Diseases and Comprehensive Research on Ageing and Health Science Research Grants for Dementia R&D from the Japan Agency for Medical Research and Development (AMED). Funding Information: the Nagahama Study Group Executive Committee is composed of the following individuals: Yasuharu Tabara, Takahisa Kawaguchi, Kazuya Setoh, Yoshimitsu Takahashi, Shinji Kosugi, Takeo Nakayama and Fumihiko Matsuda from the Centre for Genomic Medicine, Kyoto University Graduate School of Medicine (Ya.T, T.K., K.S., F.M.); Department of Health Informatics (Yo.T, T.N.); and the Department of Medical Ethics and Medical Genetics (S.K.), Kyoto University School of Public Health. Publisher Copyright: © 2022, JLE/Springer.

PY - 2022/1

Y1 - 2022/1

N2 - Background: Psoriasis is reported to be associated with systemic diseases, such as metabolic syndrome (MetS), which is related to high blood pressure, hyperglycaemia, obesity and dyslipidaemia. However, clinical factors associated with psoriasis in the general population have not been fully elucidated. Objectives: To explore the clinical factors associated with psoriasis by analysing a dataset of community-based cohort studies Materials & Methods: The study participants consisted of 9,183 apparently healthy community residents in Japan (mean age: 64.5 ± 10.7 years). The clinical parameters used in this study were obtained from a baseline investigation performed between 2008 and 2010. The history of psoriasis was queried using a structured questionnaire Results: A total of 335 participants (3.6%) had a history of psoriasis. The psoriasis group was older (64.5 ± 10.7 vs 57.9 ± 12.3 years; p < 0.001) and mostly male (43.9 vs 33.0 %, p < 0.001) compared to the non-psoriasis group. Based on univariate analysis, the prevalence of MetS was higher in the psoriasis group (19.1 vs 13.6%, odds ratio = 1.50, p = 0.004), although this association disappeared after adjustment for age and sex. Similar results were observed based on the analysis of each MetS component. Other factors associated with psoriasis were history of tinea pedis (age-and sex-adjusted odds ratio = 5.27), gout (1.97), chronic obstructive pulmonary disease (5.83), reflux oesophagitis (1.72) and depressive symptoms (1.57). After further adjustment for potential covariates, the associations with these factors remained significant. Conclusion: Several chronic conditions associated with psoriasis in the general population were identified.

AB - Background: Psoriasis is reported to be associated with systemic diseases, such as metabolic syndrome (MetS), which is related to high blood pressure, hyperglycaemia, obesity and dyslipidaemia. However, clinical factors associated with psoriasis in the general population have not been fully elucidated. Objectives: To explore the clinical factors associated with psoriasis by analysing a dataset of community-based cohort studies Materials & Methods: The study participants consisted of 9,183 apparently healthy community residents in Japan (mean age: 64.5 ± 10.7 years). The clinical parameters used in this study were obtained from a baseline investigation performed between 2008 and 2010. The history of psoriasis was queried using a structured questionnaire Results: A total of 335 participants (3.6%) had a history of psoriasis. The psoriasis group was older (64.5 ± 10.7 vs 57.9 ± 12.3 years; p < 0.001) and mostly male (43.9 vs 33.0 %, p < 0.001) compared to the non-psoriasis group. Based on univariate analysis, the prevalence of MetS was higher in the psoriasis group (19.1 vs 13.6%, odds ratio = 1.50, p = 0.004), although this association disappeared after adjustment for age and sex. Similar results were observed based on the analysis of each MetS component. Other factors associated with psoriasis were history of tinea pedis (age-and sex-adjusted odds ratio = 5.27), gout (1.97), chronic obstructive pulmonary disease (5.83), reflux oesophagitis (1.72) and depressive symptoms (1.57). After further adjustment for potential covariates, the associations with these factors remained significant. Conclusion: Several chronic conditions associated with psoriasis in the general population were identified.

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U2 - 10.1684/ejd.2022.4231

DO - 10.1684/ejd.2022.4231

M3 - Article

C2 - 35514103

AN - SCOPUS:85129353054

SN - 1952-4013

VL - 32

SP - 86

EP - 93

JO - European journal of dermatology : EJD

JF - European journal of dermatology : EJD

IS - 1

ER -

Metabolic syndrome and comorbidities in patients with psoriasis: a community-based case-control study from the Nagahama cohort in Japan

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