Metabolic syndrome and renal disease

Anna Gluba, Dimitri P. Mikhailidis, Gregory Y. H. Lip, Simon Hannam, Jacek Rysz, Maciej Banach*

*Corresponding author for this work

    Research output: Contribution to journalLiterature reviewpeer-review

    74 Citations (Scopus)

    Abstract

    The metabolic syndrome (MetS) is a cluster of risk factors including insulin resistance, dyslipidemia and hypertension which are also relevant for the development of chronic kidney disease (CKD). It has proven difficult to elucidate whether the renal dysfunction in MetS is due to the MetS itself or the individual risk factors. For example, obesity - which is also part of the MetS - may enhance the risk of renal dysfunction development probably through mechanisms associated with renal hyperfiltration, hyperperfusion and focal glomerulosclerosis. Insulin resistance also promotes kidney disease by worsening renal hemodynamics. In patients with MetS, tubular atrophy, interstitial fibrosis, and arteriolar sclerosis indicating the presence of vascular damage, have also been described. As yet, there has been little evidence that preventing or treating symptoms of the MetS protects patients from renal impairment.

    Original languageEnglish
    Pages (from-to)141-150
    Number of pages10
    JournalInternational Journal of Cardiology
    Volume164
    Issue number2
    DOIs
    Publication statusPublished - 5 Apr 2013

    Keywords

    • Dyslipidemia
    • Kidney disease
    • Kidney stones
    • Metabolic syndrome
    • Obesity
    • CHRONIC KIDNEY-DISEASE
    • ENDOPLASMIC-RETICULUM STRESS
    • NUTRITION EXAMINATION SURVEY
    • SALT-SENSITIVE HYPERTENSION
    • RANDOMIZED CONTROLLED-TRIAL
    • INSULIN-RESISTANCE SYNDROME
    • URIC-ACID NEPHROLITHIASIS
    • UNFOLDED PROTEIN RESPONSE
    • RENIN-ANGIOTENSIN SYSTEM
    • EXTREMELY OBESE-PATIENTS

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