Metabolomics as a tool to unravel the oxidative stress-induced toxicity of ambient air pollutants

TY - CHAP

T1 - Metabolomics as a tool to unravel the oxidative stress-induced toxicity of ambient air pollutants

AU - Kelly, Frank J.

AU - Fussell, Julia C.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Environmental metabolomics can sensitively quantitate thousands of chemical signals in a biological sample, providing a broad spectrum of human metabolism measurements to reveal biological effects and associated toxicological mechanisms associated with exposures to the polluting gases and aerosols in the air we breathe. This chapter reviews human, animal, and in vitro metabolic profiling studies characterizing changes in low-molecular-weight metabolites indicative of oxidative stress responses to air pollutants such as those in occupational exposures, industrial aerosols, and urban environments. Findings (e.g., lipid peroxidation, protein breakdown, mitochondrial dysfunction, and reprogramming of energy metabolism) feasibly the result of an oxidative imbalance and a subsequent antioxidant response are discussed. Continued development of this field will strengthen the causal basis for epidemiological findings associating air pollution with ill health. In doing so, it will bring us closer, via evidence-based mitigation strategies, to reduce the public health burden attributable to this complex and insidious environmental pollutant.

AB - Environmental metabolomics can sensitively quantitate thousands of chemical signals in a biological sample, providing a broad spectrum of human metabolism measurements to reveal biological effects and associated toxicological mechanisms associated with exposures to the polluting gases and aerosols in the air we breathe. This chapter reviews human, animal, and in vitro metabolic profiling studies characterizing changes in low-molecular-weight metabolites indicative of oxidative stress responses to air pollutants such as those in occupational exposures, industrial aerosols, and urban environments. Findings (e.g., lipid peroxidation, protein breakdown, mitochondrial dysfunction, and reprogramming of energy metabolism) feasibly the result of an oxidative imbalance and a subsequent antioxidant response are discussed. Continued development of this field will strengthen the causal basis for epidemiological findings associating air pollution with ill health. In doing so, it will bring us closer, via evidence-based mitigation strategies, to reduce the public health burden attributable to this complex and insidious environmental pollutant.

KW - Industrial air toxics

KW - Metabolomics

KW - Occupational exposures

KW - Oxidative stress

KW - Ozone

KW - Traffic-related air pollution

UR - http://www.scopus.com/inward/record.url?scp=85093482650&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-818606-0.00024-9

DO - 10.1016/B978-0-12-818606-0.00024-9

M3 - Chapter

AN - SCOPUS:85093482650

SP - 463

EP - 488

BT - Oxidative Stress

PB - Elsevier

ER -