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Metallostar Assemblies Based on Dithiocarbamates for Use as MRI Contrast Agents

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Metallostar Assemblies Based on Dithiocarbamates for Use as MRI Contrast Agents. / Perry, Hannah L; Yoon, Il-Chul; Chabloz, Nicolas G; Molisso, Susannah; Stasiuk, Graeme J; Botnar, René M; Wilton-Ely, James D E T.

In: INORGANIC CHEMISTRY, Vol. 59, No. 15, 03.08.2020, p. 10813-10823.

Research output: Contribution to journalArticle

Harvard

Perry, HL, Yoon, I-C, Chabloz, NG, Molisso, S, Stasiuk, GJ, Botnar, RM & Wilton-Ely, JDET 2020, 'Metallostar Assemblies Based on Dithiocarbamates for Use as MRI Contrast Agents', INORGANIC CHEMISTRY, vol. 59, no. 15, pp. 10813-10823. https://doi.org/10.1021/acs.inorgchem.0c01318

APA

Perry, H. L., Yoon, I-C., Chabloz, N. G., Molisso, S., Stasiuk, G. J., Botnar, R. M., & Wilton-Ely, J. D. E. T. (2020). Metallostar Assemblies Based on Dithiocarbamates for Use as MRI Contrast Agents. INORGANIC CHEMISTRY, 59(15), 10813-10823. https://doi.org/10.1021/acs.inorgchem.0c01318

Vancouver

Perry HL, Yoon I-C, Chabloz NG, Molisso S, Stasiuk GJ, Botnar RM et al. Metallostar Assemblies Based on Dithiocarbamates for Use as MRI Contrast Agents. INORGANIC CHEMISTRY. 2020 Aug 3;59(15):10813-10823. https://doi.org/10.1021/acs.inorgchem.0c01318

Author

Perry, Hannah L ; Yoon, Il-Chul ; Chabloz, Nicolas G ; Molisso, Susannah ; Stasiuk, Graeme J ; Botnar, René M ; Wilton-Ely, James D E T. / Metallostar Assemblies Based on Dithiocarbamates for Use as MRI Contrast Agents. In: INORGANIC CHEMISTRY. 2020 ; Vol. 59, No. 15. pp. 10813-10823.

Bibtex Download

@article{b83eba31ba4640a48926039ba9aa2da6,
title = "Metallostar Assemblies Based on Dithiocarbamates for Use as MRI Contrast Agents",
abstract = "Two different octadentate gadolinium chelates based on DO3A and DOTAGA chelates (hydration number q = 1) have been used to prepare a series of bi-, tri-, and tetrametallic d-f mixed-metal complexes. The piperazine-based dithiocarbamate linker ensures that rotation of the gadolinium chelates is restricted, leading to enhanced relaxivity (r1) values, which increase with the overall mass and number of gadolinium units. The r1 value (at 10 MHz, 25 °C) per gadolinium unit rises from 5.0 mM-1 s-1 for the Gd-DO3A-NH2 monogadolinium chelate to 9.2 mM-1 s-1 in a trigadolinium complex with a ruthenium(III) core. Using a 1.5 T clinical scanner operating at 63.87 MHz (25 °C), an 86% increase in the relaxivity per gadolinium unit is observed for this multimetallic compound compared to clinically approved Dotarem. The gadolinium complexes based on the DOTAGA chelate also performed well at 63.87 MHz, with a relaxivity value of 9.5 mM-1 s-1 per gadolinium unit being observed for the trigadolinium d-f mixed-metal complex with a ruthenium(III) core. The versatility of dithiocarbamate coordination chemistry thus provides access to a wide range of d-f hybrids with potential for use as high-performance MRI contrast agents.",
author = "Perry, {Hannah L} and Il-Chul Yoon and Chabloz, {Nicolas G} and Susannah Molisso and Stasiuk, {Graeme J} and Botnar, {Ren{\'e} M} and Wilton-Ely, {James D E T}",
year = "2020",
month = aug,
day = "3",
doi = "10.1021/acs.inorgchem.0c01318",
language = "English",
volume = "59",
pages = "10813--10823",
journal = "INORGANIC CHEMISTRY",
issn = "0020-1669",
publisher = "American Chemical Society",
number = "15",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Metallostar Assemblies Based on Dithiocarbamates for Use as MRI Contrast Agents

AU - Perry, Hannah L

AU - Yoon, Il-Chul

AU - Chabloz, Nicolas G

AU - Molisso, Susannah

AU - Stasiuk, Graeme J

AU - Botnar, René M

AU - Wilton-Ely, James D E T

PY - 2020/8/3

Y1 - 2020/8/3

N2 - Two different octadentate gadolinium chelates based on DO3A and DOTAGA chelates (hydration number q = 1) have been used to prepare a series of bi-, tri-, and tetrametallic d-f mixed-metal complexes. The piperazine-based dithiocarbamate linker ensures that rotation of the gadolinium chelates is restricted, leading to enhanced relaxivity (r1) values, which increase with the overall mass and number of gadolinium units. The r1 value (at 10 MHz, 25 °C) per gadolinium unit rises from 5.0 mM-1 s-1 for the Gd-DO3A-NH2 monogadolinium chelate to 9.2 mM-1 s-1 in a trigadolinium complex with a ruthenium(III) core. Using a 1.5 T clinical scanner operating at 63.87 MHz (25 °C), an 86% increase in the relaxivity per gadolinium unit is observed for this multimetallic compound compared to clinically approved Dotarem. The gadolinium complexes based on the DOTAGA chelate also performed well at 63.87 MHz, with a relaxivity value of 9.5 mM-1 s-1 per gadolinium unit being observed for the trigadolinium d-f mixed-metal complex with a ruthenium(III) core. The versatility of dithiocarbamate coordination chemistry thus provides access to a wide range of d-f hybrids with potential for use as high-performance MRI contrast agents.

AB - Two different octadentate gadolinium chelates based on DO3A and DOTAGA chelates (hydration number q = 1) have been used to prepare a series of bi-, tri-, and tetrametallic d-f mixed-metal complexes. The piperazine-based dithiocarbamate linker ensures that rotation of the gadolinium chelates is restricted, leading to enhanced relaxivity (r1) values, which increase with the overall mass and number of gadolinium units. The r1 value (at 10 MHz, 25 °C) per gadolinium unit rises from 5.0 mM-1 s-1 for the Gd-DO3A-NH2 monogadolinium chelate to 9.2 mM-1 s-1 in a trigadolinium complex with a ruthenium(III) core. Using a 1.5 T clinical scanner operating at 63.87 MHz (25 °C), an 86% increase in the relaxivity per gadolinium unit is observed for this multimetallic compound compared to clinically approved Dotarem. The gadolinium complexes based on the DOTAGA chelate also performed well at 63.87 MHz, with a relaxivity value of 9.5 mM-1 s-1 per gadolinium unit being observed for the trigadolinium d-f mixed-metal complex with a ruthenium(III) core. The versatility of dithiocarbamate coordination chemistry thus provides access to a wide range of d-f hybrids with potential for use as high-performance MRI contrast agents.

UR - http://www.scopus.com/inward/record.url?scp=85089193953&partnerID=8YFLogxK

U2 - 10.1021/acs.inorgchem.0c01318

DO - 10.1021/acs.inorgchem.0c01318

M3 - Article

C2 - 32677827

VL - 59

SP - 10813

EP - 10823

JO - INORGANIC CHEMISTRY

JF - INORGANIC CHEMISTRY

SN - 0020-1669

IS - 15

ER -

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