Methods and techniques for in vitro subcellular localization of radiopharmaceuticals and radionuclides

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7 Citations (Scopus)

Abstract

In oncology, the holy grail of radiotherapy is specific radiation dose deposition in tumours with minimal healthy tissue toxicity. If used appropriately, injectable, systemic radionuclide therapies could meet these criteria, even for treatment of micrometastases and single circulating tumour cells. The clinical use of α and β particle-emitting molecular radionuclide therapies is rising, however clinical translation of Auger electron-emitting radionuclides is hampered by uncertainty around their exact subcellular localisation, which in turn affects the accuracy of dosimetry. This review aims to discuss and compare the advantages and disadvantages of various subcellular localisation methods available to localise radiopharmaceuticals and radionuclides for in vitro investigations.

Original languageEnglish
Pages (from-to)18-29
Number of pages12
JournalNuclear Medicine and Biology
Volume98-99
DOIs
Publication statusPublished - 1 Jul 2021

Keywords

  • Ion beam
  • Laser ablation
  • Microautoradiography
  • Radionuclide
  • Subcellular localisation
  • X-ray fluorescence microscopy

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