Methods for assessment of Vitamin B6

Roy A. Sherwood

doi:10.1016/B978-0-12-813050-6.00009-7

Methods for assessment of Vitamin B₆

Roy A. Sherwood^*

^*Corresponding author for this work

King's College London

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

6 Citations (Scopus)

Abstract

Vitamin B6 comprises six compounds based on a 2-methyl-3-hydroxypyridine structure with differing subunits at positions C4 and C5 that are interconvertible. These are pyridoxine, pyridoxamine, and pyridoxal and their phosphorylated derivatives pyridoxine-5-phosphate, pyridoxamine-5-phosphate, and pyridoxal-5-phosphate (PLP). PLP is a cofactor in >150 different enzyme reactions including transamination and decarboxylation enzyme systems. The symptoms of vitamin B6 deficiency include peripheral neuropathy, pellagra-like syndrome with seborrheic dermatitis and glossitis. Prolonged deficiency can lead to depression, confusion, and in severe cases causes abnormalities in EEG signals and seizures. The assessment of vitamin B6 status can be undertaken through direct measurement of vitamin B6 compounds or using indirect markers that reflect the effect of deficiency on the various pathways involving PLP-dependent enzymes, e.g., kynurenines, transaminases, and various amino acids.

Original language	English
Title of host publication	Laboratory Assessment of Vitamin Status
Publisher	Elsevier
Pages	181-191
Number of pages	11
ISBN (Electronic)	9780128130506
ISBN (Print)	9780128130513
DOIs	https://doi.org/10.1016/B978-0-12-813050-6.00009-7
Publication status	Published - 1 Jan 2018

Keywords

Deficiency
Laboratory
Pyridoxal-5-phosphate
Status
Vitamin B

Access to Document

10.1016/B978-0-12-813050-6.00009-7

Cite this

@inbook{dc7a7113f2c24d9a8b04bb3d68089202,

title = "Methods for assessment of Vitamin B6",

abstract = "Vitamin B6 comprises six compounds based on a 2-methyl-3-hydroxypyridine structure with differing subunits at positions C4 and C5 that are interconvertible. These are pyridoxine, pyridoxamine, and pyridoxal and their phosphorylated derivatives pyridoxine-5-phosphate, pyridoxamine-5-phosphate, and pyridoxal-5-phosphate (PLP). PLP is a cofactor in >150 different enzyme reactions including transamination and decarboxylation enzyme systems. The symptoms of vitamin B6 deficiency include peripheral neuropathy, pellagra-like syndrome with seborrheic dermatitis and glossitis. Prolonged deficiency can lead to depression, confusion, and in severe cases causes abnormalities in EEG signals and seizures. The assessment of vitamin B6 status can be undertaken through direct measurement of vitamin B6 compounds or using indirect markers that reflect the effect of deficiency on the various pathways involving PLP-dependent enzymes, e.g., kynurenines, transaminases, and various amino acids.",

keywords = "Deficiency, Laboratory, Pyridoxal-5-phosphate, Status, Vitamin B",

author = "Sherwood, {Roy A.}",

year = "2018",

month = jan,

day = "1",

doi = "10.1016/B978-0-12-813050-6.00009-7",

language = "English",

isbn = "9780128130513",

pages = "181--191",

booktitle = "Laboratory Assessment of Vitamin Status",

publisher = "Elsevier",

address = "Netherlands",

}

TY - CHAP

T1 - Methods for assessment of Vitamin B6

AU - Sherwood, Roy A.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Vitamin B6 comprises six compounds based on a 2-methyl-3-hydroxypyridine structure with differing subunits at positions C4 and C5 that are interconvertible. These are pyridoxine, pyridoxamine, and pyridoxal and their phosphorylated derivatives pyridoxine-5-phosphate, pyridoxamine-5-phosphate, and pyridoxal-5-phosphate (PLP). PLP is a cofactor in >150 different enzyme reactions including transamination and decarboxylation enzyme systems. The symptoms of vitamin B6 deficiency include peripheral neuropathy, pellagra-like syndrome with seborrheic dermatitis and glossitis. Prolonged deficiency can lead to depression, confusion, and in severe cases causes abnormalities in EEG signals and seizures. The assessment of vitamin B6 status can be undertaken through direct measurement of vitamin B6 compounds or using indirect markers that reflect the effect of deficiency on the various pathways involving PLP-dependent enzymes, e.g., kynurenines, transaminases, and various amino acids.

AB - Vitamin B6 comprises six compounds based on a 2-methyl-3-hydroxypyridine structure with differing subunits at positions C4 and C5 that are interconvertible. These are pyridoxine, pyridoxamine, and pyridoxal and their phosphorylated derivatives pyridoxine-5-phosphate, pyridoxamine-5-phosphate, and pyridoxal-5-phosphate (PLP). PLP is a cofactor in >150 different enzyme reactions including transamination and decarboxylation enzyme systems. The symptoms of vitamin B6 deficiency include peripheral neuropathy, pellagra-like syndrome with seborrheic dermatitis and glossitis. Prolonged deficiency can lead to depression, confusion, and in severe cases causes abnormalities in EEG signals and seizures. The assessment of vitamin B6 status can be undertaken through direct measurement of vitamin B6 compounds or using indirect markers that reflect the effect of deficiency on the various pathways involving PLP-dependent enzymes, e.g., kynurenines, transaminases, and various amino acids.

KW - Deficiency

KW - Laboratory

KW - Pyridoxal-5-phosphate

KW - Status

KW - Vitamin B

UR - http://www.scopus.com/inward/record.url?scp=85081331560&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-813050-6.00009-7

DO - 10.1016/B978-0-12-813050-6.00009-7

M3 - Chapter

SN - 9780128130513

SP - 181

EP - 191

BT - Laboratory Assessment of Vitamin Status

PB - Elsevier

ER -

Methods for assessment of Vitamin B₆

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this