Methods for assessment of Vitamin B6

Roy A. Sherwood*

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    6 Citations (Scopus)


    Vitamin B6 comprises six compounds based on a 2-methyl-3-hydroxypyridine structure with differing subunits at positions C4 and C5 that are interconvertible. These are pyridoxine, pyridoxamine, and pyridoxal and their phosphorylated derivatives pyridoxine-5-phosphate, pyridoxamine-5-phosphate, and pyridoxal-5-phosphate (PLP). PLP is a cofactor in >150 different enzyme reactions including transamination and decarboxylation enzyme systems. The symptoms of vitamin B6 deficiency include peripheral neuropathy, pellagra-like syndrome with seborrheic dermatitis and glossitis. Prolonged deficiency can lead to depression, confusion, and in severe cases causes abnormalities in EEG signals and seizures. The assessment of vitamin B6 status can be undertaken through direct measurement of vitamin B6 compounds or using indirect markers that reflect the effect of deficiency on the various pathways involving PLP-dependent enzymes, e.g., kynurenines, transaminases, and various amino acids.

    Original languageEnglish
    Title of host publicationLaboratory Assessment of Vitamin Status
    Number of pages11
    ISBN (Electronic)9780128130506
    ISBN (Print)9780128130513
    Publication statusPublished - 1 Jan 2018


    • Deficiency
    • Laboratory
    • Pyridoxal-5-phosphate
    • Status
    • Vitamin B


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