Methotrexate-associated osteonecrosis of the jaw: A report of two cases

Marianne Henien; Barbara Carey; Esther Hullah; Chris Sproat; Vinod Patel

doi:10.1016/j.oooo.2017.09.005

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Methotrexate-associated osteonecrosis of the jaw: A report of two cases

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Marianne Henien, Barbara Carey, Esther Hullah, Chris Sproat, Vinod Patel

Original language	English
Journal	Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics
Early online date	21 Sep 2017
DOIs	https://doi.org/10.1016/j.oooo.2017.09.005
Accepted/In press	13 Sep 2017
E-pub ahead of print	21 Sep 2017
Additional links	Link to publication in Scopus

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Vinod Patel (Centre for Oral, Clinical & Translational Sciences)

Abstract

There has been a rise in medication-related osteonecrosis of the jaw (MRONJ) predominantly related to antiresorptive and antiangiogenic medications. More evidence is revealing that MRONJ is not limited to these drug groups. With the introduction of newer and varied medications used in the treatment of cancer and autoimmune diseases, reports of possible related osteonecrosis of the jaw (ONJ) are also on the rise. We present 2 cases of ONJ in patients with long-standing arthritis treated with methotrexate in the absence of a lymphoproliferative disorder and antiresorptive or antiangiogenic medications.

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Methotrexate-associated osteonecrosis of the jaw: A report of two cases

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