Methylomic markers of persistent childhood asthma: A longitudinal study of asthma discordant monozygotic twins.

Therese Murphy; Chloe Chung Yi Wong; Louise Arseneault; Joe Burrage; Ruby Macdonald; Eilis Hannon; Helen Fisher; Antony Paul Ambler; Terrie Edith Moffitt; Avshalom Caspi; Jonathan Mill

doi:10.1186/s13148-015-0163-4

Methylomic markers of persistent childhood asthma: A longitudinal study of asthma discordant monozygotic twins.

Therese Murphy, Chloe Chung Yi Wong, Louise Arseneault, Joe Burrage, Ruby Macdonald, Eilis Hannon, Helen Fisher, Antony Paul Ambler, Terrie Edith Moffitt, Avshalom Caspi, Jonathan Mill

Social Genetic & Developmental Psychiatry

University of Exeter

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

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Abstract

Asthma is the most common chronic inflammatory disorder in children. The etiology of asthma pathology is complex and highly heterogeneous, involving the interplay between genetic and environmental risk factors that is hypothesized to involve epigenetic processes. Our aim was to explore whether methylomic variation in early childhood is associated with discordance for asthma symptoms within monozygotic (MZ) twin-pairs recruited from the Environmental Risk (E-Risk) longitudinal twin study. We also aimed to identify differences in DNA methylation that are associated with asthma that develops in childhood and persists into early adulthood as these may represent useful prognostic biomarkers.

Original language	English
Journal	Clinical Epigenetics
DOIs	https://doi.org/10.1186/s13148-015-0163-4
Publication status	Published - 18 Dec 2015

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title = "Methylomic markers of persistent childhood asthma: A longitudinal study of asthma discordant monozygotic twins.",

abstract = "Asthma is the most common chronic inflammatory disorder in children. The etiology of asthma pathology is complex and highly heterogeneous, involving the interplay between genetic and environmental risk factors that is hypothesized to involve epigenetic processes. Our aim was to explore whether methylomic variation in early childhood is associated with discordance for asthma symptoms within monozygotic (MZ) twin-pairs recruited from the Environmental Risk (E-Risk) longitudinal twin study. We also aimed to identify differences in DNA methylation that are associated with asthma that develops in childhood and persists into early adulthood as these may represent useful prognostic biomarkers.",

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AU - Murphy, Therese

AU - Wong, Chloe Chung Yi

AU - Arseneault, Louise

AU - Burrage, Joe

AU - Macdonald, Ruby

AU - Hannon, Eilis

AU - Fisher, Helen

AU - Ambler, Antony Paul

AU - Moffitt, Terrie Edith

AU - Caspi, Avshalom

AU - Mill, Jonathan

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N2 - Asthma is the most common chronic inflammatory disorder in children. The etiology of asthma pathology is complex and highly heterogeneous, involving the interplay between genetic and environmental risk factors that is hypothesized to involve epigenetic processes. Our aim was to explore whether methylomic variation in early childhood is associated with discordance for asthma symptoms within monozygotic (MZ) twin-pairs recruited from the Environmental Risk (E-Risk) longitudinal twin study. We also aimed to identify differences in DNA methylation that are associated with asthma that develops in childhood and persists into early adulthood as these may represent useful prognostic biomarkers.

AB - Asthma is the most common chronic inflammatory disorder in children. The etiology of asthma pathology is complex and highly heterogeneous, involving the interplay between genetic and environmental risk factors that is hypothesized to involve epigenetic processes. Our aim was to explore whether methylomic variation in early childhood is associated with discordance for asthma symptoms within monozygotic (MZ) twin-pairs recruited from the Environmental Risk (E-Risk) longitudinal twin study. We also aimed to identify differences in DNA methylation that are associated with asthma that develops in childhood and persists into early adulthood as these may represent useful prognostic biomarkers.

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M3 - Article

SN - 1868-7075

JO - Clinical Epigenetics

JF - Clinical Epigenetics

ER -

Methylomic markers of persistent childhood asthma: A longitudinal study of asthma discordant monozygotic twins.

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