Methylomic markers of persistent childhood asthma: A longitudinal study of asthma discordant monozygotic twins.

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Abstract

Asthma is the most common chronic inflammatory disorder in children. The etiology of asthma pathology is complex and highly heterogeneous, involving the interplay between genetic and environmental risk factors that is hypothesized to involve epigenetic processes. Our aim was to explore whether methylomic variation in early childhood is associated with discordance for asthma symptoms within monozygotic (MZ) twin-pairs recruited from the Environmental Risk (E-Risk) longitudinal twin study. We also aimed to identify differences in DNA methylation that are associated with asthma that develops in childhood and persists into early adulthood as these may represent useful prognostic biomarkers.
Original languageEnglish
JournalClinical Epigenetics
DOIs
Publication statusPublished - 18 Dec 2015

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