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Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes

Research output: Contribution to journalArticle

James N Sleigh, Andrew P Tosolini, David Gordon, Anny Devoy, Pietro Fratta, Elizabeth M C Fisher, Kevin Talbot, Giampietro Schiavo

Original languageEnglish
Pages (from-to)3655-3662.e2
JournalCell Reports
Volume30
Issue number11
Early online date17 Mar 2020
DOIs
Publication statusPublished - 17 Mar 2020

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Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

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Abstract

Sleigh et al. address the importance of disturbances in axonal transport in two mouse models for ALS. They find that deficiencies in the in vivo axonal delivery of target tissue-derived survival factors are not a common feature of all ALS mouse models, suggesting mechanistic distinctions in different ALS-linked genes.

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