Microarray study of single nucleotide polymorphisms and expression of ATP-binding cassette genes in breast tumors

M. M. Tsyganov; M. K. Ibragimova; I. V. Karabut; M. B. Freydin; E. L. Choinzonov; N. V. Litvyakov

doi:10.1063/1.4936031

Microarray study of single nucleotide polymorphisms and expression of ATP-binding cassette genes in breast tumors

M. M. Tsyganov^*, M. K. Ibragimova, I. V. Karabut, M. B. Freydin, E. L. Choinzonov, N. V. Litvyakov

^*Corresponding author for this work

Twin Research & Genetic Epidemiology

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review

Abstract

Our previous research establishes that changes of expression of the ATP-binding cassette genes family is connected with the neoadjuvant chemotherapy effect. However, the mechanism of regulation of resistance gene expression remains unclear. As many researchers believe, single nucleotide polymorphisms can be involved in this process. Thereupon, microarray analysis is used to study polymorphisms in ATP-binding cassette genes. It is thus found that MDR gene expression is connected with 5 polymorphisms, i.e. rs241432, rs241429, rs241430, rs3784867, rs59409230, which participate in the regulation of expression of own genes.

Original language	English
Title of host publication	AIP Conference Proceedings
Publisher	American Institute of Physics Inc.
Volume	1688
ISBN (Print)	9780735413351
DOIs	https://doi.org/10.1063/1.4936031
Publication status	Published - 17 Nov 2015
Event	5th International Scientific Conference on New Operational Technologies, NEWOT 2015 - Tomsk, Russian Federation Duration: 29 Sept 2015 → 30 Sept 2015

Conference

Conference	5th International Scientific Conference on New Operational Technologies, NEWOT 2015
Country/Territory	Russian Federation
City	Tomsk
Period	29/09/2015 → 30/09/2015

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title = "Microarray study of single nucleotide polymorphisms and expression of ATP-binding cassette genes in breast tumors",

abstract = "Our previous research establishes that changes of expression of the ATP-binding cassette genes family is connected with the neoadjuvant chemotherapy effect. However, the mechanism of regulation of resistance gene expression remains unclear. As many researchers believe, single nucleotide polymorphisms can be involved in this process. Thereupon, microarray analysis is used to study polymorphisms in ATP-binding cassette genes. It is thus found that MDR gene expression is connected with 5 polymorphisms, i.e. rs241432, rs241429, rs241430, rs3784867, rs59409230, which participate in the regulation of expression of own genes.",

author = "Tsyganov, {M. M.} and Ibragimova, {M. K.} and Karabut, {I. V.} and Freydin, {M. B.} and Choinzonov, {E. L.} and Litvyakov, {N. V.}",

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doi = "10.1063/1.4936031",

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isbn = "9780735413351",

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Tsyganov, MM, Ibragimova, MK, Karabut, IV, Freydin, MB, Choinzonov, EL & Litvyakov, NV 2015, Microarray study of single nucleotide polymorphisms and expression of ATP-binding cassette genes in breast tumors. in AIP Conference Proceedings. vol. 1688, 030036, American Institute of Physics Inc., 5th International Scientific Conference on New Operational Technologies, NEWOT 2015, Tomsk, Russian Federation, 29/09/2015. https://doi.org/10.1063/1.4936031

TY - CHAP

T1 - Microarray study of single nucleotide polymorphisms and expression of ATP-binding cassette genes in breast tumors

AU - Tsyganov, M. M.

AU - Ibragimova, M. K.

AU - Karabut, I. V.

AU - Freydin, M. B.

AU - Choinzonov, E. L.

AU - Litvyakov, N. V.

PY - 2015/11/17

Y1 - 2015/11/17

N2 - Our previous research establishes that changes of expression of the ATP-binding cassette genes family is connected with the neoadjuvant chemotherapy effect. However, the mechanism of regulation of resistance gene expression remains unclear. As many researchers believe, single nucleotide polymorphisms can be involved in this process. Thereupon, microarray analysis is used to study polymorphisms in ATP-binding cassette genes. It is thus found that MDR gene expression is connected with 5 polymorphisms, i.e. rs241432, rs241429, rs241430, rs3784867, rs59409230, which participate in the regulation of expression of own genes.

AB - Our previous research establishes that changes of expression of the ATP-binding cassette genes family is connected with the neoadjuvant chemotherapy effect. However, the mechanism of regulation of resistance gene expression remains unclear. As many researchers believe, single nucleotide polymorphisms can be involved in this process. Thereupon, microarray analysis is used to study polymorphisms in ATP-binding cassette genes. It is thus found that MDR gene expression is connected with 5 polymorphisms, i.e. rs241432, rs241429, rs241430, rs3784867, rs59409230, which participate in the regulation of expression of own genes.

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M3 - Conference paper

AN - SCOPUS:84984534191

SN - 9780735413351

VL - 1688

BT - AIP Conference Proceedings

PB - American Institute of Physics Inc.

T2 - 5th International Scientific Conference on New Operational Technologies, NEWOT 2015

Y2 - 29 September 2015 through 30 September 2015

ER -

Microarray study of single nucleotide polymorphisms and expression of ATP-binding cassette genes in breast tumors

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