Microbe-host interplay in atopic dermatitis and psoriasis

Nanna Fyhrquist; Gareth Sion Muirhead; Stephanie Prast-Nielsen; Marine Jeanmougin; Peter Olah; Tiina Skoog; Gerome   Jules-Clement; Micha Feld; Mauricio  Barrientos-Somarribas; Hanna Sinkko; Ellen H.   van den Bogaard; Patrick L.J.M.  Zeeuwen; Gijs Rikken; Joost Schalkwijk; Niehues Niehues; Walter Däubener; Silvia Kathrin  Eller; Helen Alexander; Davide Pennino; Sari Suomela; Ioannis Tessas; Emilia Lybeck; Anna M. Baran; Hamid Darban; Gangwar Roopesh Singh; Ulrich Gerstel; Katharina Jahn; Piia Karisola; Lee Yan; Britta Hansmann; Shintaro Katayama; Stephan Meller; Max Bylesjö; Philippe Hupé; Francesca Levi-Schaffer; Dario Greco; Annamari Ranki; Jens M.  Schröder; Jonathan Nicholas William Noel Barker; Juha Kere; Sophia Tsoka; Antti Lauerma; Vassili Soumelis; Frank Oliver Nestle; Bernhard Homey; Björn Andersson; Harri Alenius

doi:10.1038/s41467-019-12253-y

Microbe-host interplay in atopic dermatitis and psoriasis

Nanna Fyhrquist, Gareth Sion Muirhead, Stephanie Prast-Nielsen, Marine Jeanmougin, Peter Olah, Tiina Skoog, Gerome Jules-Clement, Micha Feld, Mauricio Barrientos-Somarribas, Hanna Sinkko, Ellen H. van den Bogaard, Patrick L.J.M. Zeeuwen, Gijs Rikken, Joost Schalkwijk, Niehues Niehues, Walter Däubener, Silvia Kathrin Eller, Helen Alexander, Davide Pennino, Sari SuomelaIoannis Tessas, Emilia Lybeck, Anna M. Baran, Hamid Darban, Gangwar Roopesh Singh, Ulrich Gerstel, Katharina Jahn, Piia Karisola, Lee Yan, Britta Hansmann, Shintaro Katayama, Stephan Meller, Max Bylesjö, Philippe Hupé, Francesca Levi-Schaffer, Dario Greco, Annamari Ranki, Jens M. Schröder, Jonathan Nicholas William Noel Barker, Juha Kere, Sophia Tsoka, Antti Lauerma, Vassili Soumelis, Frank Oliver Nestle, Bernhard Homey, Björn Andersson, Harri Alenius

Karolinska Institute

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Abstract

Despite recent advances in understanding microbial diversity in skin homeostasis, the relevance of microbial dysbiosis in inflammatory disease is poorly understood. Here we perform a comparative analysis of skin microbial communities coupled to global patterns of cutaneous gene expression in patients with atopic dermatitis or psoriasis. The skin microbiota is analysed by 16S amplicon or whole genome sequencing and the skin transcriptome by microarrays, followed by integration of the data layers. We find that atopic dermatitis and psoriasis can be classified by distinct microbes, which differ from healthy volunteers microbiome composition. Atopic dermatitis is dominated by a single microbe (Staphylococcus aureus), and associated with a disease relevant host transcriptomic signature enriched for skin barrier function, tryptophan metabolism and immune activation. In contrast, psoriasis is characterized by co-occurring communities of microbes with weak associations with disease related gene expression. Our work provides a basis for biomarker discovery and targeted therapies in skin dysbiosis.

Original language	English
Article number	4703
Journal	Nature Communications
Volume	10
Issue number	1
Early online date	16 Oct 2019
DOIs	https://doi.org/10.1038/s41467-019-12253-y
Publication status	E-pub ahead of print - 16 Oct 2019

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10.1038/s41467-019-12253-y

Microbe-host interplay in_FYHRQUIST_Accepted27August2019Publishedonline16October2019_GOLD VoR (CC BY)Final published version, 2.55 MBLicence: CC BY

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Fyhrquist, N., Muirhead, G. S., Prast-Nielsen, S., Jeanmougin, M., Olah, P., Skoog, T., Jules-Clement, G., Feld, M., Barrientos-Somarribas, M., Sinkko, H., van den Bogaard, E. H., Zeeuwen, P. L. J. M., Rikken, G., Schalkwijk, J., Niehues, N., Däubener, W., Eller, S. K., Alexander, H., Pennino, D., ... Alenius, H. (2019). Microbe-host interplay in atopic dermatitis and psoriasis. Nature Communications, 10(1), [4703]. https://doi.org/10.1038/s41467-019-12253-y

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title = "Microbe-host interplay in atopic dermatitis and psoriasis",

abstract = "Despite recent advances in understanding microbial diversity in skin homeostasis, the relevance of microbial dysbiosis in inflammatory disease is poorly understood. Here we perform a comparative analysis of skin microbial communities coupled to global patterns of cutaneous gene expression in patients with atopic dermatitis or psoriasis. The skin microbiota is analysed by 16S amplicon or whole genome sequencing and the skin transcriptome by microarrays, followed by integration of the data layers. We find that atopic dermatitis and psoriasis can be classified by distinct microbes, which differ from healthy volunteers microbiome composition. Atopic dermatitis is dominated by a single microbe (Staphylococcus aureus), and associated with a disease relevant host transcriptomic signature enriched for skin barrier function, tryptophan metabolism and immune activation. In contrast, psoriasis is characterized by co-occurring communities of microbes with weak associations with disease related gene expression. Our work provides a basis for biomarker discovery and targeted therapies in skin dysbiosis.",

author = "Nanna Fyhrquist and Muirhead, {Gareth Sion} and Stephanie Prast-Nielsen and Marine Jeanmougin and Peter Olah and Tiina Skoog and Gerome Jules-Clement and Micha Feld and Mauricio Barrientos-Somarribas and Hanna Sinkko and {van den Bogaard}, {Ellen H.} and Zeeuwen, {Patrick L.J.M.} and Gijs Rikken and Joost Schalkwijk and Niehues Niehues and Walter D{\"a}ubener and Eller, {Silvia Kathrin} and Helen Alexander and Davide Pennino and Sari Suomela and Ioannis Tessas and Emilia Lybeck and Baran, {Anna M.} and Hamid Darban and {Roopesh Singh}, Gangwar and Ulrich Gerstel and Katharina Jahn and Piia Karisola and Lee Yan and Britta Hansmann and Shintaro Katayama and Stephan Meller and Max Bylesj{\"o} and Philippe Hup{\'e} and Francesca Levi-Schaffer and Dario Greco and Annamari Ranki and Schr{\"o}der, {Jens M.} and Barker, {Jonathan Nicholas William Noel} and Juha Kere and Sophia Tsoka and Antti Lauerma and Vassili Soumelis and Nestle, {Frank Oliver} and Bernhard Homey and Bj{\"o}rn Andersson and Harri Alenius",

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Fyhrquist, N, Muirhead, GS, Prast-Nielsen, S, Jeanmougin, M, Olah, P, Skoog, T, Jules-Clement, G, Feld, M, Barrientos-Somarribas, M, Sinkko, H, van den Bogaard, EH, Zeeuwen, PLJM, Rikken, G, Schalkwijk, J, Niehues, N, Däubener, W, Eller, SK, Alexander, H , Pennino, D, Suomela, S, Tessas, I, Lybeck, E, Baran, AM, Darban, H, Roopesh Singh, G, Gerstel, U, Jahn, K, Karisola, P, Yan, L, Hansmann, B, Katayama, S, Meller, S, Bylesjö, M, Hupé, P, Levi-Schaffer, F, Greco, D, Ranki, A, Schröder, JM, Barker, JNWN, Kere, J, Tsoka, S, Lauerma, A, Soumelis, V, Nestle, FO, Homey, B, Andersson, B & Alenius, H 2019, 'Microbe-host interplay in atopic dermatitis and psoriasis', Nature Communications, vol. 10, no. 1, 4703. https://doi.org/10.1038/s41467-019-12253-y

TY - JOUR

T1 - Microbe-host interplay in atopic dermatitis and psoriasis

AU - Fyhrquist, Nanna

AU - Muirhead, Gareth Sion

AU - Prast-Nielsen, Stephanie

AU - Jeanmougin, Marine

AU - Olah, Peter

AU - Skoog, Tiina

AU - Jules-Clement, Gerome

AU - Feld, Micha

AU - Barrientos-Somarribas, Mauricio

AU - Sinkko, Hanna

AU - van den Bogaard, Ellen H.

AU - Zeeuwen, Patrick L.J.M.

AU - Rikken, Gijs

AU - Schalkwijk, Joost

AU - Niehues, Niehues

AU - Däubener, Walter

AU - Eller, Silvia Kathrin

AU - Alexander, Helen

AU - Pennino, Davide

AU - Suomela, Sari

AU - Tessas, Ioannis

AU - Lybeck, Emilia

AU - Baran, Anna M.

AU - Darban, Hamid

AU - Roopesh Singh, Gangwar

AU - Gerstel, Ulrich

AU - Jahn, Katharina

AU - Karisola, Piia

AU - Yan, Lee

AU - Hansmann, Britta

AU - Katayama, Shintaro

AU - Meller, Stephan

AU - Bylesjö, Max

AU - Hupé, Philippe

AU - Levi-Schaffer, Francesca

AU - Greco, Dario

AU - Ranki, Annamari

AU - Schröder, Jens M.

AU - Barker, Jonathan Nicholas William Noel

AU - Kere, Juha

AU - Tsoka, Sophia

AU - Lauerma, Antti

AU - Soumelis, Vassili

AU - Nestle, Frank Oliver

AU - Homey, Bernhard

AU - Andersson, Björn

AU - Alenius, Harri

PY - 2019/10/16

Y1 - 2019/10/16

N2 - Despite recent advances in understanding microbial diversity in skin homeostasis, the relevance of microbial dysbiosis in inflammatory disease is poorly understood. Here we perform a comparative analysis of skin microbial communities coupled to global patterns of cutaneous gene expression in patients with atopic dermatitis or psoriasis. The skin microbiota is analysed by 16S amplicon or whole genome sequencing and the skin transcriptome by microarrays, followed by integration of the data layers. We find that atopic dermatitis and psoriasis can be classified by distinct microbes, which differ from healthy volunteers microbiome composition. Atopic dermatitis is dominated by a single microbe (Staphylococcus aureus), and associated with a disease relevant host transcriptomic signature enriched for skin barrier function, tryptophan metabolism and immune activation. In contrast, psoriasis is characterized by co-occurring communities of microbes with weak associations with disease related gene expression. Our work provides a basis for biomarker discovery and targeted therapies in skin dysbiosis.

AB - Despite recent advances in understanding microbial diversity in skin homeostasis, the relevance of microbial dysbiosis in inflammatory disease is poorly understood. Here we perform a comparative analysis of skin microbial communities coupled to global patterns of cutaneous gene expression in patients with atopic dermatitis or psoriasis. The skin microbiota is analysed by 16S amplicon or whole genome sequencing and the skin transcriptome by microarrays, followed by integration of the data layers. We find that atopic dermatitis and psoriasis can be classified by distinct microbes, which differ from healthy volunteers microbiome composition. Atopic dermatitis is dominated by a single microbe (Staphylococcus aureus), and associated with a disease relevant host transcriptomic signature enriched for skin barrier function, tryptophan metabolism and immune activation. In contrast, psoriasis is characterized by co-occurring communities of microbes with weak associations with disease related gene expression. Our work provides a basis for biomarker discovery and targeted therapies in skin dysbiosis.

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U2 - 10.1038/s41467-019-12253-y

DO - 10.1038/s41467-019-12253-y

M3 - Article

SN - 2041-1723

VL - 10

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 4703

ER -

Microbe-host interplay in atopic dermatitis and psoriasis

Abstract

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