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Microbial Translocation in HIV-1 infected patients

Research output: Contribution to journalMeeting abstractpeer-review

Zisis Kozlakidis, Bethlehem Arefaine, Sylvie Clairefond, John Cason

Original languageEnglish
JournalBiopreservation And Biobanking

King's Authors


Microbial translocation – as indicated by detectable plasma
Lipopolysaccharides (LPS) - is increased in patients infected with HIV.
However, it is not clear whether, or not, levels of plasma LPS are prognostic
for HIV associated disease progression. To examine the association between
plasma LPS and disease progression we examined 267 banked plasmas from
untreated HIV patients. Our results show that LPS concentrations were
unassociated with circulating CD4+ T-cell numbers or plasma HIV viral
loads. LPS was significantly negatively associated with the time of sampling
after diagnosis. We were able to demonstrate that LPS concentrations
significantly increase in HIV patients in the first six months after diagnosis to
levels which exceed those observed amongst patients in the chronic phase.
Amongst patients, those with chronic disease or who were viral controllers
had lower levels of plasma LPS and those with AIDS had higher levels

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