Microbiota, immunity and the liver

Trishan Vaikunthanathan, N. Safinia*, G. Lombardi, R. I. Lechler

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    The gut harbors a complex community of over 100 trillion microbial cells known to exist in symbiotic harmony with the host influencing human physiology, metabolism, nutrition and immune function. It is now widely accepted that perturbations of this close partnership results in the pathogenesis of several major diseases with increasing evidence highlighting their role outside of the intestinal tract. The intimate proximity and circulatory loop of the liver and the gut has attracted significant attention regarding the role of the microbiota in the development and progression of liver disease. Here we give an overview of the interaction between the microbiota and the immune system and focus on their convincing role in both the propagation and treatment of liver disease.

    Original languageEnglish
    Pages (from-to)36-49
    Number of pages14
    JournalImmunology Letters
    Volume171
    Early online date2 Feb 2016
    DOIs
    Publication statusPublished - 1 Mar 2016

    Keywords

    • Immunity
    • Liver disease
    • Microbiota

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