Microbiota, immunity and the liver

Trishan Vaikunthanathan; N. Safinia; G. Lombardi; R. I. Lechler

doi:10.1016/j.imlet.2016.01.008

Microbiota, immunity and the liver

Trishan Vaikunthanathan, N. Safinia^*, G. Lombardi, R. I. Lechler

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The gut harbors a complex community of over 100 trillion microbial cells known to exist in symbiotic harmony with the host influencing human physiology, metabolism, nutrition and immune function. It is now widely accepted that perturbations of this close partnership results in the pathogenesis of several major diseases with increasing evidence highlighting their role outside of the intestinal tract. The intimate proximity and circulatory loop of the liver and the gut has attracted significant attention regarding the role of the microbiota in the development and progression of liver disease. Here we give an overview of the interaction between the microbiota and the immune system and focus on their convincing role in both the propagation and treatment of liver disease.

Original language	English
Pages (from-to)	36-49
Number of pages	14
Journal	Immunology Letters
Volume	171
Early online date	2 Feb 2016
DOIs	https://doi.org/10.1016/j.imlet.2016.01.008
Publication status	Published - 1 Mar 2016

Keywords

Immunity
Liver disease
Microbiota

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.imlet.2016.01.008

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title = "Microbiota, immunity and the liver",

abstract = "The gut harbors a complex community of over 100 trillion microbial cells known to exist in symbiotic harmony with the host influencing human physiology, metabolism, nutrition and immune function. It is now widely accepted that perturbations of this close partnership results in the pathogenesis of several major diseases with increasing evidence highlighting their role outside of the intestinal tract. The intimate proximity and circulatory loop of the liver and the gut has attracted significant attention regarding the role of the microbiota in the development and progression of liver disease. Here we give an overview of the interaction between the microbiota and the immune system and focus on their convincing role in both the propagation and treatment of liver disease.",

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AU - Vaikunthanathan, Trishan

AU - Safinia, N.

AU - Lombardi, G.

AU - Lechler, R. I.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - The gut harbors a complex community of over 100 trillion microbial cells known to exist in symbiotic harmony with the host influencing human physiology, metabolism, nutrition and immune function. It is now widely accepted that perturbations of this close partnership results in the pathogenesis of several major diseases with increasing evidence highlighting their role outside of the intestinal tract. The intimate proximity and circulatory loop of the liver and the gut has attracted significant attention regarding the role of the microbiota in the development and progression of liver disease. Here we give an overview of the interaction between the microbiota and the immune system and focus on their convincing role in both the propagation and treatment of liver disease.

AB - The gut harbors a complex community of over 100 trillion microbial cells known to exist in symbiotic harmony with the host influencing human physiology, metabolism, nutrition and immune function. It is now widely accepted that perturbations of this close partnership results in the pathogenesis of several major diseases with increasing evidence highlighting their role outside of the intestinal tract. The intimate proximity and circulatory loop of the liver and the gut has attracted significant attention regarding the role of the microbiota in the development and progression of liver disease. Here we give an overview of the interaction between the microbiota and the immune system and focus on their convincing role in both the propagation and treatment of liver disease.

KW - Immunity

KW - Liver disease

KW - Microbiota

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VL - 171

SP - 36

EP - 49

JO - Immunology Letters

JF - Immunology Letters

ER -

Microbiota, immunity and the liver

Abstract

Keywords

UN SDGs

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