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Microbiota, immunity and the liver

Research output: Contribution to journalArticle

Trishan Vaikunthanathan, N. Safinia, G. Lombardi, R. I. Lechler

Original languageEnglish
Pages (from-to)36-49
Number of pages14
JournalImmunology Letters
Volume171
Early online date2 Feb 2016
DOIs
Publication statusPublished - 1 Mar 2016

King's Authors

Abstract

The gut harbors a complex community of over 100 trillion microbial cells known to exist in symbiotic harmony with the host influencing human physiology, metabolism, nutrition and immune function. It is now widely accepted that perturbations of this close partnership results in the pathogenesis of several major diseases with increasing evidence highlighting their role outside of the intestinal tract. The intimate proximity and circulatory loop of the liver and the gut has attracted significant attention regarding the role of the microbiota in the development and progression of liver disease. Here we give an overview of the interaction between the microbiota and the immune system and focus on their convincing role in both the propagation and treatment of liver disease.

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