Microemulsion-based media as novel drug delivery systems

TY - JOUR

T1 - Microemulsion-based media as novel drug delivery systems

AU - Lawrence, M J

AU - Rees, G D

PY - 2000/12/6

Y1 - 2000/12/6

N2 - Microemulsions are clear, stable, isotropic mixtures of oil; water and surfactant, frequently in combination with a cosurfactant. These systems are currently of interest to the pharmaceutical scientist because of their considerable potential to act as drug delivery vehicles by incorporating a wide range of drug molecules. In order to appreciate the potential of microemulsions as delivery vehicles, this review gives an overview of the formation and phase behaviour and characterization of microemulsions. The use of microemulsions and closely related microemulsion-based systems as drug delivery vehicles is reviewed, with particular emphasis being placed on recent developments and future directions.

AB - Microemulsions are clear, stable, isotropic mixtures of oil; water and surfactant, frequently in combination with a cosurfactant. These systems are currently of interest to the pharmaceutical scientist because of their considerable potential to act as drug delivery vehicles by incorporating a wide range of drug molecules. In order to appreciate the potential of microemulsions as delivery vehicles, this review gives an overview of the formation and phase behaviour and characterization of microemulsions. The use of microemulsions and closely related microemulsion-based systems as drug delivery vehicles is reviewed, with particular emphasis being placed on recent developments and future directions.

U2 - 10.1016/S0169-409X(00)00103-4

DO - 10.1016/S0169-409X(00)00103-4

M3 - Literature review

VL - 45

SP - 89

EP - 121

JO - ADVANCED DRUG DELIVERY REVIEWS

JF - ADVANCED DRUG DELIVERY REVIEWS

IS - 1

M1 - N/A

ER -