Microemulsion-based media as novel drug delivery systems

M. Jayne Lawrence; Gareth D. Rees

doi:10.1016/j.addr.2012.09.018

Microemulsion-based media as novel drug delivery systems

M. Jayne Lawrence^*, Gareth D. Rees

^*Corresponding author for this work

Institute of Pharmaceutical Science

Research output: Contribution to journal › Literature review › peer-review

351 Citations (Scopus)

Abstract

Microemulsions are clear, stable, isotropic mixtures of oil, water and surfactant, frequently in combination with a cosurfactant. These systems are currently of interest to the pharmaceutical scientist because of their considerable potential to act as drug delivery vehicles by incorporating a wide range of drug molecules. In order to appreciate the potential of microemulsions as delivery vehicles, this review gives an overview of the formation and phase behaviour and characterization of microemulsions. The use of microemulsions and closely related microemulsion-based systems as drug delivery vehicles is reviewed, with particular emphasis being placed on recent developments and future directions.

Original language	English
Pages (from-to)	175-193
Number of pages	19
Journal	ADVANCED DRUG DELIVERY REVIEWS
Volume	64
Issue number	Supplement
DOIs	https://doi.org/10.1016/j.addr.2012.09.018
Publication status	Published - Dec 2012

Keywords

IN-OIL MICROEMULSIONS
LECITHIN-BASED MICROEMULSIONS
TERNARY PHASE-DIAGRAMS
SOLID LIPID NANOPARTICLES
MEDIUM-CHAIN GLYCERIDES
PARTICLE-SIZE ANALYSIS
INTESTINAL PERMEABILITY ENHANCEMENT
PREPARING NONTOXIC MICROEMULSIONS
WATER PHOSPHOLIPID MICROEMULSIONS
SORBITAN MONOSTEARATE ORGANOGELS

Access to Document

10.1016/j.addr.2012.09.018

351 Citations
1 Literature review

Microemulsion-based media as novel drug delivery systems
Lawrence, M. J. & Rees, G. D., 6 Dec 2000, In: ADVANCED DRUG DELIVERY REVIEWS. 45, 1, p. 89 - 121 33 p., N/A.
Research output: Contribution to journal › Literature review › peer-review
1738 Citations (Scopus)

Cite this

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title = "Microemulsion-based media as novel drug delivery systems",

abstract = "Microemulsions are clear, stable, isotropic mixtures of oil, water and surfactant, frequently in combination with a cosurfactant. These systems are currently of interest to the pharmaceutical scientist because of their considerable potential to act as drug delivery vehicles by incorporating a wide range of drug molecules. In order to appreciate the potential of microemulsions as delivery vehicles, this review gives an overview of the formation and phase behaviour and characterization of microemulsions. The use of microemulsions and closely related microemulsion-based systems as drug delivery vehicles is reviewed, with particular emphasis being placed on recent developments and future directions. ",

keywords = "IN-OIL MICROEMULSIONS, LECITHIN-BASED MICROEMULSIONS, TERNARY PHASE-DIAGRAMS, SOLID LIPID NANOPARTICLES, MEDIUM-CHAIN GLYCERIDES, PARTICLE-SIZE ANALYSIS, INTESTINAL PERMEABILITY ENHANCEMENT, PREPARING NONTOXIC MICROEMULSIONS, WATER PHOSPHOLIPID MICROEMULSIONS, SORBITAN MONOSTEARATE ORGANOGELS",

author = "Lawrence, {M. Jayne} and Rees, {Gareth D.}",

year = "2012",

month = dec,

doi = "10.1016/j.addr.2012.09.018",

language = "English",

volume = "64",

pages = "175--193",

journal = "ADVANCED DRUG DELIVERY REVIEWS",

issn = "0169-409X",

publisher = "Elsevier",

number = "Supplement",

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T1 - Microemulsion-based media as novel drug delivery systems

AU - Lawrence, M. Jayne

AU - Rees, Gareth D.

PY - 2012/12

Y1 - 2012/12

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AB - Microemulsions are clear, stable, isotropic mixtures of oil, water and surfactant, frequently in combination with a cosurfactant. These systems are currently of interest to the pharmaceutical scientist because of their considerable potential to act as drug delivery vehicles by incorporating a wide range of drug molecules. In order to appreciate the potential of microemulsions as delivery vehicles, this review gives an overview of the formation and phase behaviour and characterization of microemulsions. The use of microemulsions and closely related microemulsion-based systems as drug delivery vehicles is reviewed, with particular emphasis being placed on recent developments and future directions.

KW - IN-OIL MICROEMULSIONS

KW - LECITHIN-BASED MICROEMULSIONS

KW - TERNARY PHASE-DIAGRAMS

KW - SOLID LIPID NANOPARTICLES

KW - MEDIUM-CHAIN GLYCERIDES

KW - PARTICLE-SIZE ANALYSIS

KW - INTESTINAL PERMEABILITY ENHANCEMENT

KW - PREPARING NONTOXIC MICROEMULSIONS

KW - WATER PHOSPHOLIPID MICROEMULSIONS

KW - SORBITAN MONOSTEARATE ORGANOGELS

U2 - 10.1016/j.addr.2012.09.018

DO - 10.1016/j.addr.2012.09.018

M3 - Literature review

SN - 0169-409X

VL - 64

SP - 175

EP - 193

JO - ADVANCED DRUG DELIVERY REVIEWS

JF - ADVANCED DRUG DELIVERY REVIEWS

IS - Supplement

ER -

Microemulsion-based media as novel drug delivery systems

Abstract

Keywords

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Research output

Microemulsion-based media as novel drug delivery systems

Cite this