Microemulsion-based media as novel drug delivery systems

M. Jayne Lawrence*, Gareth D. Rees

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

325 Citations (Scopus)

Abstract

Microemulsions are clear, stable, isotropic mixtures of oil, water and surfactant, frequently in combination with a cosurfactant. These systems are currently of interest to the pharmaceutical scientist because of their considerable potential to act as drug delivery vehicles by incorporating a wide range of drug molecules. In order to appreciate the potential of microemulsions as delivery vehicles, this review gives an overview of the formation and phase behaviour and characterization of microemulsions. The use of microemulsions and closely related microemulsion-based systems as drug delivery vehicles is reviewed, with particular emphasis being placed on recent developments and future directions.
Original languageEnglish
Pages (from-to)175-193
Number of pages19
JournalADVANCED DRUG DELIVERY REVIEWS
Volume64
Issue numberSupplement
DOIs
Publication statusPublished - Dec 2012

Keywords

  • IN-OIL MICROEMULSIONS
  • LECITHIN-BASED MICROEMULSIONS
  • TERNARY PHASE-DIAGRAMS
  • SOLID LIPID NANOPARTICLES
  • MEDIUM-CHAIN GLYCERIDES
  • PARTICLE-SIZE ANALYSIS
  • INTESTINAL PERMEABILITY ENHANCEMENT
  • PREPARING NONTOXIC MICROEMULSIONS
  • WATER PHOSPHOLIPID MICROEMULSIONS
  • SORBITAN MONOSTEARATE ORGANOGELS

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