Microglia toxicity in preterm brain injury

Ana A. Baburamani; Veena G. Supramaniam; Henrik Hagberg; Carina Mallard

doi:10.1016/j.reprotox.2014.04.002

Microglia toxicity in preterm brain injury

Ana A. Baburamani, Veena G. Supramaniam, Henrik Hagberg, Carina Mallard^*

^*Corresponding author for this work

Perinatal Imaging & Health

University of Gothenburg

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Microglia are the resident phagocytic cells of the central nervous system. During brain development they are also imperative for apoptosis of excessive neurons, synaptic pruning, phagocytosis of debris and maintaining brain homeostasis. Brain damage results in a fast and dynamic microglia reaction, which can influence the extent and distribution of subsequent neuronal dysfunction. As a consequence, microglia responses can promote tissue protection and repair following brain injury, or become detrimental for the tissue integrity and functionality. In this review, we will describe microglia responses in the human developing brain in association with injury, with particular focus on the preterm infant. We also explore microglia responses and mechanisms of microglia toxicity in animal models of preterm white matter injury and in vitro primary microglia cell culture experiments.

Original language	English
Pages (from-to)	106-112
Number of pages	7
Journal	Reproductive Toxicology
Volume	48
DOIs	https://doi.org/10.1016/j.reprotox.2014.04.002
Publication status	Published - Sept 2014

Keywords

Perinatal brain injury
Neuroinflammation
WHITE-MATTER INJURY
TUMOR-NECROSIS-FACTOR
BACTERIAL-ENDOTOXIN SENSITIZES
ORGANOTYPIC SLICE CULTURES
NITRIC-OXIDE SYNTHASE
CELLS IN-VITRO
ACTIVATED MICROGLIA
PERIVENTRICULAR LEUKOMALACIA
FETAL SHEEP
GLUTAMATE-RECEPTOR

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10.1016/j.reprotox.2014.04.002

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title = "Microglia toxicity in preterm brain injury",

abstract = "Microglia are the resident phagocytic cells of the central nervous system. During brain development they are also imperative for apoptosis of excessive neurons, synaptic pruning, phagocytosis of debris and maintaining brain homeostasis. Brain damage results in a fast and dynamic microglia reaction, which can influence the extent and distribution of subsequent neuronal dysfunction. As a consequence, microglia responses can promote tissue protection and repair following brain injury, or become detrimental for the tissue integrity and functionality. In this review, we will describe microglia responses in the human developing brain in association with injury, with particular focus on the preterm infant. We also explore microglia responses and mechanisms of microglia toxicity in animal models of preterm white matter injury and in vitro primary microglia cell culture experiments.",

keywords = "Perinatal brain injury, Neuroinflammation, WHITE-MATTER INJURY, TUMOR-NECROSIS-FACTOR, BACTERIAL-ENDOTOXIN SENSITIZES, ORGANOTYPIC SLICE CULTURES, NITRIC-OXIDE SYNTHASE, CELLS IN-VITRO, ACTIVATED MICROGLIA, PERIVENTRICULAR LEUKOMALACIA, FETAL SHEEP, GLUTAMATE-RECEPTOR",

author = "Baburamani, {Ana A.} and Supramaniam, {Veena G.} and Henrik Hagberg and Carina Mallard",

year = "2014",

month = sep,

doi = "10.1016/j.reprotox.2014.04.002",

language = "English",

volume = "48",

pages = "106--112",

journal = "Reproductive Toxicology",

issn = "0890-6238",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Microglia toxicity in preterm brain injury

AU - Baburamani, Ana A.

AU - Supramaniam, Veena G.

AU - Hagberg, Henrik

AU - Mallard, Carina

PY - 2014/9

Y1 - 2014/9

N2 - Microglia are the resident phagocytic cells of the central nervous system. During brain development they are also imperative for apoptosis of excessive neurons, synaptic pruning, phagocytosis of debris and maintaining brain homeostasis. Brain damage results in a fast and dynamic microglia reaction, which can influence the extent and distribution of subsequent neuronal dysfunction. As a consequence, microglia responses can promote tissue protection and repair following brain injury, or become detrimental for the tissue integrity and functionality. In this review, we will describe microglia responses in the human developing brain in association with injury, with particular focus on the preterm infant. We also explore microglia responses and mechanisms of microglia toxicity in animal models of preterm white matter injury and in vitro primary microglia cell culture experiments.

AB - Microglia are the resident phagocytic cells of the central nervous system. During brain development they are also imperative for apoptosis of excessive neurons, synaptic pruning, phagocytosis of debris and maintaining brain homeostasis. Brain damage results in a fast and dynamic microglia reaction, which can influence the extent and distribution of subsequent neuronal dysfunction. As a consequence, microglia responses can promote tissue protection and repair following brain injury, or become detrimental for the tissue integrity and functionality. In this review, we will describe microglia responses in the human developing brain in association with injury, with particular focus on the preterm infant. We also explore microglia responses and mechanisms of microglia toxicity in animal models of preterm white matter injury and in vitro primary microglia cell culture experiments.

KW - Perinatal brain injury

KW - Neuroinflammation

KW - WHITE-MATTER INJURY

KW - TUMOR-NECROSIS-FACTOR

KW - BACTERIAL-ENDOTOXIN SENSITIZES

KW - ORGANOTYPIC SLICE CULTURES

KW - NITRIC-OXIDE SYNTHASE

KW - CELLS IN-VITRO

KW - ACTIVATED MICROGLIA

KW - PERIVENTRICULAR LEUKOMALACIA

KW - FETAL SHEEP

KW - GLUTAMATE-RECEPTOR

U2 - 10.1016/j.reprotox.2014.04.002

DO - 10.1016/j.reprotox.2014.04.002

M3 - Article

SN - 0890-6238

VL - 48

SP - 106

EP - 112

JO - Reproductive Toxicology

JF - Reproductive Toxicology

ER -

Microglia toxicity in preterm brain injury

Abstract

Keywords

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