Microglia toxicity in preterm brain injury

Ana A. Baburamani, Veena G. Supramaniam, Henrik Hagberg, Carina Mallard*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)

Abstract

Microglia are the resident phagocytic cells of the central nervous system. During brain development they are also imperative for apoptosis of excessive neurons, synaptic pruning, phagocytosis of debris and maintaining brain homeostasis. Brain damage results in a fast and dynamic microglia reaction, which can influence the extent and distribution of subsequent neuronal dysfunction. As a consequence, microglia responses can promote tissue protection and repair following brain injury, or become detrimental for the tissue integrity and functionality. In this review, we will describe microglia responses in the human developing brain in association with injury, with particular focus on the preterm infant. We also explore microglia responses and mechanisms of microglia toxicity in animal models of preterm white matter injury and in vitro primary microglia cell culture experiments.

Original languageEnglish
Pages (from-to)106-112
Number of pages7
JournalReproductive Toxicology
Volume48
DOIs
Publication statusPublished - Sept 2014

Keywords

  • Perinatal brain injury
  • Neuroinflammation
  • WHITE-MATTER INJURY
  • TUMOR-NECROSIS-FACTOR
  • BACTERIAL-ENDOTOXIN SENSITIZES
  • ORGANOTYPIC SLICE CULTURES
  • NITRIC-OXIDE SYNTHASE
  • CELLS IN-VITRO
  • ACTIVATED MICROGLIA
  • PERIVENTRICULAR LEUKOMALACIA
  • FETAL SHEEP
  • GLUTAMATE-RECEPTOR

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