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Micronutrients in critically ill patients with severe acute kidney injury – a prospective study

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Micronutrients in critically ill patients with severe acute kidney injury – a prospective study. / Ostermann, Marlies; Summers, Jennifer; Lei, Katie; Card, David; Harrington, Dominic J.; Sherwood, Roy; Turner, Charles; Dalton, Neil; Peacock, Janet; Bear, Danielle E.

In: Scientific Reports, Vol. 10, No. 1, 1505, 01.12.2020.

Research output: Contribution to journalArticle

Harvard

Ostermann, M, Summers, J, Lei, K, Card, D, Harrington, DJ, Sherwood, R, Turner, C, Dalton, N, Peacock, J & Bear, DE 2020, 'Micronutrients in critically ill patients with severe acute kidney injury – a prospective study', Scientific Reports, vol. 10, no. 1, 1505. https://doi.org/10.1038/s41598-020-58115-2

APA

Ostermann, M., Summers, J., Lei, K., Card, D., Harrington, D. J., Sherwood, R., ... Bear, D. E. (2020). Micronutrients in critically ill patients with severe acute kidney injury – a prospective study. Scientific Reports, 10(1), [1505]. https://doi.org/10.1038/s41598-020-58115-2

Vancouver

Ostermann M, Summers J, Lei K, Card D, Harrington DJ, Sherwood R et al. Micronutrients in critically ill patients with severe acute kidney injury – a prospective study. Scientific Reports. 2020 Dec 1;10(1). 1505. https://doi.org/10.1038/s41598-020-58115-2

Author

Ostermann, Marlies ; Summers, Jennifer ; Lei, Katie ; Card, David ; Harrington, Dominic J. ; Sherwood, Roy ; Turner, Charles ; Dalton, Neil ; Peacock, Janet ; Bear, Danielle E. / Micronutrients in critically ill patients with severe acute kidney injury – a prospective study. In: Scientific Reports. 2020 ; Vol. 10, No. 1.

Bibtex Download

@article{b639ecfdef304583b225e83cf357e5ed,
title = "Micronutrients in critically ill patients with severe acute kidney injury – a prospective study",
abstract = "Malnutrition is common in patients with acute kidney injury (AKI) and the risk of mortality is high, especially if renal replacement therapy is needed. Between April 2013 through April 2014, we recruited critically ill adult patients (≥18 years) with severe AKI in two University hospitals in London, UK, and measured serial plasma concentrations of vitamin B1, B6, B12, C and D, folate, selenium, zinc, copper, iron, carnitine and 22 amino acids for six consecutive days. In patients receiving continuous renal replacement therapy (CRRT), the concentrations of the same nutrients in the effluent were also determined. CRRT patients (n = 31) had lower plasma concentrations of citrulline, glutamic acid and carnitine at 24 hrs after enrolment and significantly lower plasma glutamic acid concentrations (74.4 versus 98.2 μmol/L) at day 6 compared to non-CRRT patients (n = 24). All amino acids, trace elements, vitamin C and folate were detectable in effluent fluid. In >30{\%} of CRRT and non-CRRT patients, the plasma nutrient concentrations of zinc, iron, selenium, vitamin D3, vitamin C, trytophan, taurine, histidine and hydroxyproline were below the reference range throughout the 6-day period. In conclusion, altered micronutrient status is common in patients with severe AKI regardless of treatment with CRRT.",
author = "Marlies Ostermann and Jennifer Summers and Katie Lei and David Card and Harrington, {Dominic J.} and Roy Sherwood and Charles Turner and Neil Dalton and Janet Peacock and Bear, {Danielle E.}",
year = "2020",
month = "12",
day = "1",
doi = "10.1038/s41598-020-58115-2",
language = "English",
volume = "10",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Micronutrients in critically ill patients with severe acute kidney injury – a prospective study

AU - Ostermann, Marlies

AU - Summers, Jennifer

AU - Lei, Katie

AU - Card, David

AU - Harrington, Dominic J.

AU - Sherwood, Roy

AU - Turner, Charles

AU - Dalton, Neil

AU - Peacock, Janet

AU - Bear, Danielle E.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Malnutrition is common in patients with acute kidney injury (AKI) and the risk of mortality is high, especially if renal replacement therapy is needed. Between April 2013 through April 2014, we recruited critically ill adult patients (≥18 years) with severe AKI in two University hospitals in London, UK, and measured serial plasma concentrations of vitamin B1, B6, B12, C and D, folate, selenium, zinc, copper, iron, carnitine and 22 amino acids for six consecutive days. In patients receiving continuous renal replacement therapy (CRRT), the concentrations of the same nutrients in the effluent were also determined. CRRT patients (n = 31) had lower plasma concentrations of citrulline, glutamic acid and carnitine at 24 hrs after enrolment and significantly lower plasma glutamic acid concentrations (74.4 versus 98.2 μmol/L) at day 6 compared to non-CRRT patients (n = 24). All amino acids, trace elements, vitamin C and folate were detectable in effluent fluid. In >30% of CRRT and non-CRRT patients, the plasma nutrient concentrations of zinc, iron, selenium, vitamin D3, vitamin C, trytophan, taurine, histidine and hydroxyproline were below the reference range throughout the 6-day period. In conclusion, altered micronutrient status is common in patients with severe AKI regardless of treatment with CRRT.

AB - Malnutrition is common in patients with acute kidney injury (AKI) and the risk of mortality is high, especially if renal replacement therapy is needed. Between April 2013 through April 2014, we recruited critically ill adult patients (≥18 years) with severe AKI in two University hospitals in London, UK, and measured serial plasma concentrations of vitamin B1, B6, B12, C and D, folate, selenium, zinc, copper, iron, carnitine and 22 amino acids for six consecutive days. In patients receiving continuous renal replacement therapy (CRRT), the concentrations of the same nutrients in the effluent were also determined. CRRT patients (n = 31) had lower plasma concentrations of citrulline, glutamic acid and carnitine at 24 hrs after enrolment and significantly lower plasma glutamic acid concentrations (74.4 versus 98.2 μmol/L) at day 6 compared to non-CRRT patients (n = 24). All amino acids, trace elements, vitamin C and folate were detectable in effluent fluid. In >30% of CRRT and non-CRRT patients, the plasma nutrient concentrations of zinc, iron, selenium, vitamin D3, vitamin C, trytophan, taurine, histidine and hydroxyproline were below the reference range throughout the 6-day period. In conclusion, altered micronutrient status is common in patients with severe AKI regardless of treatment with CRRT.

UR - http://www.scopus.com/inward/record.url?scp=85078712874&partnerID=8YFLogxK

U2 - 10.1038/s41598-020-58115-2

DO - 10.1038/s41598-020-58115-2

M3 - Article

C2 - 32001725

AN - SCOPUS:85078712874

VL - 10

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 1505

ER -

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