King's College London

Research portal

Micro-patterned surface construction on BCP ceramics and the regulation on inflammation-involved osteogenic differentiation

Research output: Contribution to journalArticle

Jing Wang, Yangyang Su, Lizhou Xu, Danyang Li

Original languageEnglish
Article number111220
JournalMaterials Science and Engineering C
PublishedNov 2020

King's Authors


The surface characteristics of bioceramics are critical in modulating the cellular events in osteogenesis. However, understanding on the effect of surface properties-derived inflammation on osteogenesis is unclear. In this study, dense biphase calcium phosphate (BCP) ceramics with various surface micropatterns were fabricated to investigate the effect of surface morphologies on the behaviors and functions of macrophages, and the subsequent cascade regulation on the osteogenic differentiation of preosteoblast. We found that the change of surface roughness and wettability of single convex in micropatterns with different sizes could make dramatic differences on the adherence, distribution and morphology of macrophages. Specifically, the patterned surface with smaller single convex area was more likely to drive macrophages towards M1-like phenotype, as was determined by the upregulated gene expression and molecular secretion of M1-specific markers compared with flat surface. Moreover, the macrophages/scaffolds-derived medium showed an obvious promotion on osteogenic differentiation of MC3T3-E1 cells that suggested the surface characteristics of BCP ceramics are important in terms of scaffolds-induced inflammation, which might contribute to its osteogenesis potential.

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454