MicroRNAs affect dendritic cells function and phenotype

Lesley A Smyth; Dominic Boardman; Sim Tung; Robert Lechler; Giovanna Lombardi

doi:10.1111/imm.12390

MicroRNAs affect dendritic cells function and phenotype

Lesley A Smyth, Dominic Boardman, Sim Tung, Robert Lechler, Giovanna Lombardi

Research output: Contribution to journal › Article › peer-review

98 Citations (Scopus)

Abstract

MicroRNA (miRNA) are small, non coding RNA molecules that have been linked with immunity through regulating/modulating gene expression. A role for these molecules in T and B cell development and function has been well established. An increasing body of literature now highlights the importance of specific miRNAs in dendritic cells (DCs) development as well as their maturation process, antigen presentation capacity and cytokine release. Given the unique role of DCs within the immune system, linking the innate and the adaptive immune response, understanding how specific miRNAs affect DCs function is of importance for understanding disease. In this review we summarise recent developments in miRNA and DCs research, highlighting the requirement of miRNAs in DC lineage commitment from bone marrow progenitors to the development of subsets such as pDCs and cDCs. In addition, we discuss how infections and tumors modulate miRNA expression and consequently DC function.

Original language	English
Pages (from-to)	197-205
Number of pages	9
Journal	Immunology
Volume	144
Issue number	2
DOIs	https://doi.org/10.1111/imm.12390
Publication status	Published - Feb 2015

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title = "MicroRNAs affect dendritic cells function and phenotype",

abstract = "MicroRNA (miRNA) are small, non coding RNA molecules that have been linked with immunity through regulating/modulating gene expression. A role for these molecules in T and B cell development and function has been well established. An increasing body of literature now highlights the importance of specific miRNAs in dendritic cells (DCs) development as well as their maturation process, antigen presentation capacity and cytokine release. Given the unique role of DCs within the immune system, linking the innate and the adaptive immune response, understanding how specific miRNAs affect DCs function is of importance for understanding disease. In this review we summarise recent developments in miRNA and DCs research, highlighting the requirement of miRNAs in DC lineage commitment from bone marrow progenitors to the development of subsets such as pDCs and cDCs. In addition, we discuss how infections and tumors modulate miRNA expression and consequently DC function. ",

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AU - Boardman, Dominic

AU - Tung, Sim

AU - Lechler, Robert

AU - Lombardi, Giovanna

PY - 2015/2

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AB - MicroRNA (miRNA) are small, non coding RNA molecules that have been linked with immunity through regulating/modulating gene expression. A role for these molecules in T and B cell development and function has been well established. An increasing body of literature now highlights the importance of specific miRNAs in dendritic cells (DCs) development as well as their maturation process, antigen presentation capacity and cytokine release. Given the unique role of DCs within the immune system, linking the innate and the adaptive immune response, understanding how specific miRNAs affect DCs function is of importance for understanding disease. In this review we summarise recent developments in miRNA and DCs research, highlighting the requirement of miRNAs in DC lineage commitment from bone marrow progenitors to the development of subsets such as pDCs and cDCs. In addition, we discuss how infections and tumors modulate miRNA expression and consequently DC function.

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MicroRNAs affect dendritic cells function and phenotype

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