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MicroRNAs affect dendritic cells function and phenotype

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)197-205
Number of pages9
JournalImmunology
Volume144
Issue number2
DOIs
Publication statusPublished - Feb 2015

King's Authors

Abstract

MicroRNA (miRNA) are small, non coding RNA molecules that have been linked with immunity through regulating/modulating gene expression. A role for these molecules in T and B cell development and function has been well established. An increasing body of literature now highlights the importance of specific miRNAs in dendritic cells (DCs) development as well as their maturation process, antigen presentation capacity and cytokine release. Given the unique role of DCs within the immune system, linking the innate and the adaptive immune response, understanding how specific miRNAs affect DCs function is of importance for understanding disease. In this review we summarise recent developments in miRNA and DCs research, highlighting the requirement of miRNAs in DC lineage commitment from bone marrow progenitors to the development of subsets such as pDCs and cDCs. In addition, we discuss how infections and tumors modulate miRNA expression and consequently DC function.

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